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公开(公告)号：US20230408805A1
公开(公告)日：2023-12-21
申请号：US18205152
申请日：2023-06-02
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Celalettin Yurdakul , Haonan Zong , M. Selim Ünlü
CPC classification number: G02B21/16 , G02B21/025 , G02B21/361
Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.
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公开(公告)号：US20230280501A1
公开(公告)日：2023-09-07
申请号：US18117763
申请日：2023-03-06
Applicant: Trustees of Boston University
Inventor： M. Selim Unlu , Nese Lortlar Unlu , Celalettin Yurdakul , Iris Celebi
Abstract: A method and device for visualizing a sample having a tissue section embedded in a solid material are provided. The method and device include applying an incident light to the tissue section embedded in the solid material. The tissue section embedded in the solid material is disposed on a layered structure configured to reduce optical back reflection at an interface between the tissue section embedded in the solid material and the layered structure. The incident light passes through the tissue section embedded in the solid material and the layered structure with reduced reflection at each of the interfaces such that visualizing one or more artifacts from reflecting the incident light from surfaces of the tissue section embedded in the solid material is reduced.
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公开(公告)号：US20240036339A1
公开(公告)日：2024-02-01
申请号：US18226483
申请日：2023-07-26
Applicant: Trustees of Boston University
Inventor： M. Selim Ünlü , Mete Aslan , Iris Celebi , Celalettin Yurdakul , Allison Marie Marn
CPC classification number: G02B27/0927 , G02B27/0916 , G02B27/48 , G02B21/08
Abstract: An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device.
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公开(公告)号：US20210172863A1
公开(公告)日：2021-06-10
申请号：US17115017
申请日：2020-12-08
Applicant: Trustees of Boston University
Inventor： M. Selim Ünlü , Celalettin Yurdakul , Allison Marie Marn
Abstract: An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.
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公开(公告)号：US10585042B2
公开(公告)日：2020-03-10
申请号：US16432376
申请日：2019-06-05
Applicant: TRUSTEES OF BOSTON UNIVERSITY , NANOVIEW BIOSCIENCES, INC.
Inventor： M. Selim Ünlü , Derin Sevenler , Jacob Trueb , Oguzhan Avci , Celalettin Yurdakul , Steven Scherr , George G. Daaboul , David S. Freedman
Abstract: A system for analyzing one or more liquid samples includes a microwell plate including a plurality of rows of wells configured to store liquid samples, a sensor array that is moveable relative to the microwell plate along a first axis between a first position and a second position to allow a portion of the sensor array to be disposed within a first one of the plurality of rows of wells when the sensor array is in the second position, an objective, and one or more linear translation stages configured to move the microwell plate relative to the objective (i) along a second axis that is orthogonal to the first axis, (ii) along a third axis that is orthogonal to the first axis and the second axis, or (iii) both (i) and (ii).
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Patent Agency Ranking
公开(公告)号：US20250060606A1
公开(公告)日：2025-02-20
申请号：US18909517
申请日：2024-10-08
Applicant: Trustees of Boston University
Inventor： M. Selim Ünlü , Mete Aslan , Iris Celebi , Celalettin Yurdakul , Allison Marie Marn
Abstract: An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device.
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公开(公告)号：US12085691B2
公开(公告)日：2024-09-10
申请号：US18117763
申请日：2023-03-06
Applicant: Trustees of Boston University
Inventor： M. Selim Unlu , Nese Lortlar Unlu , Celalettin Yurdakul , Iris Celebi
Abstract: A method and device for visualizing a sample having a tissue section embedded in a solid material are provided. The method and device include applying an incident light to the tissue section embedded in the solid material. The tissue section embedded in the solid material is disposed on a layered structure configured to reduce optical back reflection at an interface between the tissue section embedded in the solid material and the layered structure. The incident light passes through the tissue section embedded in the solid material and the layered structure with reduced reflection at each of the interfaces such that visualizing one or more artifacts from reflecting the incident light from surfaces of the tissue section embedded in the solid material is reduced.
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公开(公告)号：US11709352B2
公开(公告)日：2023-07-25
申请号：US17704896
申请日：2022-03-25
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Celalettin Yurdakul , Haonan Zong , M. Selim Ünlü
CPC classification number: G02B21/16 , G02B21/025 , G02B21/361
Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.
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公开(公告)号：US11137343B2
公开(公告)日：2021-10-05
申请号：US17115017
申请日：2020-12-08
Applicant: Trustees of Boston University
Inventor： M. Selim Ünlü , Celalettin Yurdakul , Allison Marie Marn
IPC: G01N21/17 , G01N21/45 , G01N21/3563 , G01N21/31
Abstract: An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.
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公开(公告)号：US20250012557A1
公开(公告)日：2025-01-09
申请号：US18761623
申请日：2024-07-02
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Haonan Zong , Celalettin Yurdakul , M. Selim Ünlü
IPC: G01B9/02091
Abstract: A wide-field bond-selective optical coherence tomography (OCT) system and method for imaging a sample includes generating infrared light and directing the infrared light onto the sample to selectively heat the sample. Probe light is also directed onto the sample. A first actuator provides sample depth scanning with respect to a first objective in a reference arm of the system, and a second actuator provides sample depth scanning with respect to a second objective in a sample arm of the system. A detection system receives scattered probe light reflected from the sample. A change in the received probe light from the sample that is indicative of absorption of infrared light.
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