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    COMPOSITIONS AND TREATMENTS FOR PNEUMONIA IN ANIMALS
    21.
    发明申请
    COMPOSITIONS AND TREATMENTS FOR PNEUMONIA IN ANIMALS 审中-公开
    动物中肺炎的组成和治疗

    公开(公告)号：WO1991015237A1

    公开(公告)日：1991-10-17

    申请号：PCT/CA1990000170

    申请日：1990-05-25

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UNIVERSITY OF SASKATCHEWAN ,  ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

    IPC: A61K39/102

    CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

    Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

    Abstract translation: 公开了用于刺激抗呼吸系统疾病例如肺炎的免疫的解脲索氏溶血杆菌的新蛋白质和亚基抗原，包括运​​送发热性肺炎。 亚单位抗原包括解脲葡萄球菌菌毛蛋白，溶血性解纤维细胞溶血素受体蛋白和溶血性解水多糖50K外膜蛋白和解放军溶血白细胞毒素的免疫原性氨基酸序列。 抗原可以单独或组合地用于疫苗组合物中。 还公开了接种疫苗的方法以及制备疫苗中使用的亚基抗原的方法。

    AQUEOUS ALCOHOLIC ALKALINE PROCESS FOR CATIONIZATION AND ANIONIZATION OF STARCH
    24.
    发明申请
    AQUEOUS ALCOHOLIC ALKALINE PROCESS FOR CATIONIZATION AND ANIONIZATION OF STARCH 审中-公开
    水溶性碱性碱性沉淀法和淀粉分离法

    公开(公告)号：WO1996009327A1

    公开(公告)日：1996-03-28

    申请号：PCT/CA1995000538

    申请日：1995-09-22

    Applicant: UNIVERSITY OF SASKATCHEWAN ,  SOSULSKI, Robert, W. ,  BHIRUD, Prakash, R. ,  KWEON, Meera ,  TYLER, Robert, T.

    Inventor： UNIVERSITY OF SASKATCHEWAN

    IPC: C08B31/12

    CPC classification number: C08B31/125 ,  C08B31/16 ,  Y02P20/582

    Abstract: A starch cationization process comprises suspending the starch in an aqueous alcoholic alkaline solvent containing a critical level of water (starch to water ratio 1:3 to 3:1), heating the reaction mixture for a few minutes at 30-90 DEG C, adding a cationizing reagent such as 3-chloro-2-hydroxypropyl-trimethylammonium chloride, heating for 1-24 hours at 30-80 DEG C, neutralizing, centrifuging, washing and drying of the cake to yield cationic starches with degrees of substitution of 0.01 to 0.12. Amphoteric starches are produced by simultaneous or sequential reaction of an anionic reagent with or after the cationic reagent in the aqueous alcoholic alkaline solvent. Solvent recovery and concentration of effluent solids is facilitated by distillation.

    Abstract translation: 淀粉阳离子化方法包括将淀粉悬浮在含有临界水含量（淀粉与水的比例为1:3至3:1）的含水醇性碱性溶剂中，在30-90℃加热反应混合物几分钟，加入 阳离子化试剂如3-氯-2-羟丙基三甲基氯化铵，在30-80℃下加热1-24小时，中和，离心，洗涤和干燥滤饼，得到取代度为0.01的阳离子淀粉 0.12。 两性淀粉通过阴离子试剂与阳离子试剂在含水醇性碱性溶剂中或之后的同时或顺序反应产生。 通过蒸馏促进溶剂回收和流出物固体的浓缩。

    QUINOA SAPONIN COMPOSITIONS AND METHODS OF USE
    25.
    发明申请
    QUINOA SAPONIN COMPOSITIONS AND METHODS OF USE 审中-公开
    QUINOA SAPONIN组合物和使用方法

    公开(公告)号：WO1996003998A1

    公开(公告)日：1996-02-15

    申请号：PCT/CA1995000442

    申请日：1995-07-31

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UNIVERSITY OF SASKATCHEWAN ,  ESTRADA, Alberto ,  REDMOND, Mark, J. ,  LAARVELD, Bernard

    IPC: A61K35/78

    CPC classification number: A61K36/185 ,  A61K36/73 ,  A61K2300/00

    Abstract: Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful as immunological adjuvants, to stimulate nonspecific immunity, as well as to enhance an immunological response to a selected antigen. The Quinoa saponin compositions can also be used to enhance mucosal absorption of a drug administered therewith.

    Abstract translation: 公开了新的藜麦皂苷药物组合物。 该组合物可用作免疫佐剂，以刺激非特异性免疫，以及增强对所选抗原的免疫应答。 喹啉皂苷组合物也可用于增强与其一起施用的药物的粘膜吸收。

    ASSESSMENT OF ION AVAILABILITY IN HETEROGENEOUS MEDIA USING ION-EXCHANGE MEMBRANES
    28.
    发明申请
    ASSESSMENT OF ION AVAILABILITY IN HETEROGENEOUS MEDIA USING ION-EXCHANGE MEMBRANES 审中-公开
    使用离子交换膜评估异构介质中的离子可用性

    公开(公告)号：WO1993016382A1

    公开(公告)日：1993-08-19

    申请号：PCT/CA1993000056

    申请日：1993-02-10

    Applicant: UNIVERSITY OF SASKATCHEWAN ,  SCHOENAU, Jeffrey, John ,  HUANG, Weize

    Inventor： UNIVERSITY OF SASKATCHEWAN

    IPC: G01N33/24

    CPC classification number: G01N33/24 ,  G01N1/08 ,  G01N30/00 ,  G01N30/02 ,  G01N2030/0095 ,  G01N2030/062 ,  B01D15/36

    Abstract: The invention relates to a kit for the measurement of anion, cation or zwitterion availability in a medium or for the measurement of free inorganic ions in disrupted cells from plant or animal tissue. The kit comprises ion-exchange material having a measurable ion uptake potential for immobilizing available ions from the medium on the material following contact on the material with the medium or suspension. It also comprises means to remove particulate solids from the material after having contacted the medium with the material. Preferably, the ion-exchange material is cation and/or anion-exchange material in the form of rigid or flexible films, sheets, membranes or the like. The invention also relates to a method for the on-site in situ measurement of anion and/or cation availability in a solid medium and to a method for measuring free organic ions in cells from plant or animal tissue. It also relates to ion-exchange material for immobilizing available ions in soil, sediment or water media and to a cation and/or anion-exchange membrane buried underneath the surface of a soil sample or site, the membrane being in ion-exchange relationship with available ions in the soil. The present invention represents an improvement over the prior art in that it provides means for quickly determining ion availability in a particular media without the necessity of collecting media samples for laboratory testing.

    Abstract translation: 本发明涉及一种用于测量培养基中阴离子，阳离子或两性离子可用性的试剂盒或用于测量植物或动物组织破碎细胞中游离无机离子的试剂盒。 该试剂盒包括具有可测量的离子吸收电位的离子交换材料，用于在与介质或悬浮液在材料上接触之后将来自培养基的可用离子固定在材料上。 它还包括在使介质与材料接触之后从材料中除去颗粒固体的装置。 优选地，离子交换材料是刚性或柔性膜，片，膜等形式的阳离子和/或阴离子交换材料。 本发明还涉及现场原位测量固体介质中阴离子和/或阳离子可用性的方法以及用于测量来自植物或动物组织的细胞中的游离有机离子的方法。 它还涉及用于将有用离子固定在土壤，沉积物或水介质中的离子交换材料以及埋在土壤样品或位点表面下方的阳离子和/或阴离子交换膜，该膜与离子交换关系为 可用离子在土壤中。 本发明代表了对现有技术的改进，因为其提供了用于快速确定特定介质中的离子可用性的手段，而无需采集用于实验室测试的介质样品。

    ACUTE PHASE PROTEINS FOR DETECTION AND PROGNOSIS OF INFECTION AND TISSUE DAMAGE
    29.
    发明申请
    ACUTE PHASE PROTEINS FOR DETECTION AND PROGNOSIS OF INFECTION AND TISSUE DAMAGE 审中-公开
    用于检测和预防感染和组织损伤的急性期相关蛋白

    公开(公告)号：WO1993009142A1

    公开(公告)日：1993-05-13

    申请号：PCT/CA1992000476

    申请日：1992-11-06

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UNIVERSITY OF SASKATCHEWAN ,  CAMPOS, Manuel ,  REDMOND, Mark, J. ,  HARLAND, Richard

    IPC: C07K15/00

    CPC classification number: C07K14/47 ,  C07K14/811 ,  C07K16/18

    Abstract: Acute phase proteins and antibodies thereto are disclosed, as well as methods of determining the presence and severity of infection and tissue damage by testing for these proteins. 17.5 kDa, 23 kDa and 37 kDa proteins have been identified in bovine subjects suffering from both infection and chemically induced tissue damage. The proteins are indicative of the severity and prognosis of disease. Antibodies thereto are useful in diagnostic assays.

    Abstract translation: 公开了急性期蛋白质及其抗体，以及通过测试这些蛋白质来确定感染和组织损伤的存在和严重程度的方法。 已经在感染和化学诱导的组织损伤的牛受试者中鉴定了17.5kDa，23kDa和37kDa的蛋白质。 蛋白质指示疾病的严重性和预后。 其抗体可用于诊断测定。

    VACCINES FOR ACTINOBACILLUS PLEUROPNEUMONIAE
    30.
    发明申请
    VACCINES FOR ACTINOBACILLUS PLEUROPNEUMONIAE 审中-公开
    ACTINOBACILLUS PLEUROPNEUMONIAE的疫苗

    公开(公告)号：WO1993008283A1

    公开(公告)日：1993-04-29

    申请号：PCT/CA1992000460

    申请日：1992-10-21

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UNIVERSITY OF SASKATCHEWAN ,  POTTER, Andrew, A. ,  GERLACH, Gerald, F. ,  WILLSON, Philip, J. ,  ROSSI-CAMPOS, Amalia

    IPC: C12N15/31

    CPC classification number: C07K14/285 ,  A61K39/00

    Abstract: Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one A. pleuropneumoniae transferrin binding protein and/or one A. pleuropneumoniae cytolysin and/or one A. pleuropneumoniae APP4. Also disclosed are DNA sequences encoding these proteins, vectors including these sequences and host cells transformed with these vectors. The vaccines can be used to treat or prevent porcine respiratory infections.

    Abstract translation: 公开了用于针对放线杆菌胸膜肺炎放线芽孢杆菌的新型疫苗。 疫苗含有至少一种胸膜肺炎放线芽孢杆菌转运蛋白结合蛋白和/或一种胸膜肺炎放线芽孢杆菌细胞溶解素和/或一种胸膜肺炎放线菌APP4。 还公开了编码这些蛋白质的DNA序列，包括这些序列的载体和用这些载体转化的宿主细胞。 疫苗可用于治疗或预防猪呼吸道感染。

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