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公开(公告)号：NZ734041A
公开(公告)日：2022-02-25
申请号：NZ73404116
申请日：2016-01-29
Applicant: VERTEX PHARMA , BIOMED VALLEY DISCOVERIES INC
Inventor： DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC: C07D401/04
Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.
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公开(公告)号：AU2020257041A1
公开(公告)日：2020-11-12
申请号：AU2020257041
申请日：2020-10-20
Applicant: BIOMED VALLEY DISCOVERIES INC , VERTEX PHARMA
Inventor： DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC: C07D401/04
Abstract: : The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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公开(公告)号：LT3424920T
公开(公告)日：2020-08-10
申请号：LT18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O`NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：ES2604480T5
公开(公告)日：2020-03-17
申请号：ES11715637
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , ALARGOVA ROSSITZA GUEORGUIEVA , KAUSHIK RITU ROHIT , KADIYALA IRINA NIKOLAEVNA , YOUNG CHRISTOPHER RYAN
IPC: A61K9/16 , A61K9/20 , A61K9/28 , A61K31/443 , A61K31/47 , C07D213/75 , C07D405/12 , C07D405/14 , C07D451/02
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公开(公告)号：HUE041877T2
公开(公告)日：2019-06-28
申请号：HUE14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: A61P35/00
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Patent Agency Ranking
公开(公告)号：ES2705342T3
公开(公告)日：2019-03-22
申请号：ES14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: Un co-cristal que comprende un compuesto de la fórmula:**Fórmula** un formador de co-cristal, en la que el formador de co-cristal es ácido adípico, en la que cada uno de R1 y R2 es independientemente hidrógeno o deuterio.
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公开(公告)号：PL3057953T3
公开(公告)日：2019-01-31
申请号：PL14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：AU2018217249A1
公开(公告)日：2018-09-13
申请号：AU2018217249
申请日：2018-08-15
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R' and R2 is hydrogen or deterium and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：HK1244274A1
公开(公告)日：2018-08-03
申请号：HK18103713
申请日：2018-03-16
Applicant: BIOMED VALLEY DISCOVERIES INC , VERTEX PHARMA
Inventor： DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC: C07D20060101
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公开(公告)号：AU2014337154B2
公开(公告)日：2018-06-28
申请号：AU2014337154
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R
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