Patent search ap:("VERTEX PHARMA") AND inv:"VAN ALSTEN JOHN GREGG" Page 1

1.

发明申请
METHODS OF STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED NUCLEOSIDE ANALOGS 审中-公开
Title translation: 取代的核苷类似物的立体选择性合成方法

公开(公告)号：WO2014164533A8

公开(公告)日：2015-07-23

申请号：PCT/US2014022723

申请日：2014-03-10

Applicant: VERTEX PHARMA

Inventor： ROSE PETER JAMISON , JUNG YOUNG CHUN , BLIGH CAVAN MCKEON , IBRAHIM SHEREEN , ANZALONE LUIGI , MILLER DAVID B JR , VAN ALSTEN JOHN GREGG , CURRAN TIMOTHY THOMAS

IPC: C07F9/02 , C07F9/165

CPC classification number: C07H1/02 , C07F9/20 , C07F9/242 , C07F9/26 , C07F9/585 , C07F9/65586 , C07H19/10

Abstract: The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

Abstract translation: 本发明涉及用于产生硫代磷酸酯化合物的新的非对映选择性合成。实例包括可用于治疗疾病和/或病症如病毒感染的核苷硫代磷酸酯类似物。

2.

发明专利
Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK 未知

公开(公告)号：PL3424920T3

公开(公告)日：2020-11-16

申请号：PL18188034

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/14 , A61K31/506 , A61P35/00

3.

发明专利
SUKRISTALI (S)-N-METIL-8-(1-((2′-METIL-[4,5′-BIPTRIMIDIN]-6-TL)AMINO)PROPAN-2-TL)KINOLIN-4-KARBOKSAMIDA I NJEGOVIH DEUTERIRANIH DERIVATA KAO INHIBITORA DNA-PK 未知

公开(公告)号：HRP20201011T1

公开(公告)日：2020-10-16

申请号：HRP20201011

申请日：2020-06-26

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/14 , A61K31/506 , A61P35/00

4.

发明专利
CO-KRYSTALLER AF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLIN-4-CARBOXAMID OG DEUTEREDE DERIVATER DERAF SOM DNA-PK-INHIBITORER 未知

公开(公告)号：DK3424920T3

公开(公告)日：2020-06-08

申请号：DK18188034

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/14 , A61K31/506 , A61P35/00

5.

发明专利
CO-KRYSTALLER AF (S)-N-METHYL-8-(1-((2'-METHYL-[4,5'-BIPYRIMIDIN]-6-YL)AMINO)PROPAN-2-YL)QUINOLIN-4-CARBOXAMID OG DEUTEREREDE DERIVATER DERAF SOM DNA-PK-INHIBITORER 未知

公开(公告)号：DK3057953T3

公开(公告)日：2018-11-19

申请号：DK14799578

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA , MUDUNURI PRAVEEN

IPC: C07D401/14 , A61K31/506 , A61P35/00

6.

发明专利
未知

公开(公告)号：RU2016118771A3

公开(公告)日：2018-07-10

申请号：RU2016118771

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA , O'NEIL SIMON ADAM , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , STAVROPOULOS KATHY , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME WIREDU , ZHANG YUEGANG

7.

发明专利
Co-cristales que comprenden un compuesto derivado de quinolina-2carboxamida de fórmula (i) y un formador de cristales; composiciones que los comprenden; método de preparación de los co-cristales y uso de estos en la preparación de un medicamento útil para el tratamiento de cáncer 未知

公开(公告)号：CL2016000916A1

公开(公告)日：2016-11-11

申请号：CL2016000916

申请日：2016-04-15

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT

IPC: C07D401/14 , A61K31/506 , A61P35/00

Abstract: Co-cristales que comprenden un compuesto derivado de quinolina-2carboxamida de fórmula (I) y un formador de cristales; composiciones que los comprenden; método de preparación de los co-cristales y uso de estos en la preparación de un medicamento útil para el tratamiento de cáncer

8.

发明专利
Inhibitors of influenza viruses replication 未知

公开(公告)号：NZ719729A

公开(公告)日：2022-04-29

申请号：NZ71972914

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： ASMAL MOHAMMED , LEDEBOER MARK , MEDEK ALES , MUDUNURI PRAVEEN , WALDO MICHAEL , O’NEIL SIMON , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME , MACIKENAS DAINIUS , SHI YI , JURKAUSKAS VALDAS , JONES STEVEN , BYRN RANDAL , ROBERTSON SARAH , TSAI WANJUNG

IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04

Abstract: Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

9.

发明专利
(S)-N-METIL-8-(1-((2`-METIL-[4,5`-BIPIRIMIDIN]-6-IL)AMINO)PROPAN-2-IL)CHINOLIN-4-KARBOKSAMIDO IR JO DEUTERINTŲ DARINIŲ, KAIP DNR-PK INHIBITORIŲ, BENDRI KRISTALAI 未知

公开(公告)号：LT3424920T

公开(公告)日：2020-08-10

申请号：LT18188034

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME , O`NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/14 , A61K31/506 , A61P35/00

10.

发明专利
INHIBITORI REPLIKACIJE VIRUSA INFLUENCE 未知

公开(公告)号：HRP20191525T1

公开(公告)日：2019-11-29

申请号：HRP20191525

申请日：2019-08-26

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG

IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04

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