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公开(公告)号：LT3424920T
公开(公告)日：2020-08-10
申请号：LT18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O`NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：HUE041877T2
公开(公告)日：2019-06-28
申请号：HUE14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: A61P35/00
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公开(公告)号：ES2705342T3
公开(公告)日：2019-03-22
申请号：ES14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: Un co-cristal que comprende un compuesto de la fórmula:**Fórmula** un formador de co-cristal, en la que el formador de co-cristal es ácido adípico, en la que cada uno de R1 y R2 es independientemente hidrógeno o deuterio.
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公开(公告)号：PL3057953T3
公开(公告)日：2019-01-31
申请号：PL14799578
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
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公开(公告)号：AU2018217249A1
公开(公告)日：2018-09-13
申请号：AU2018217249
申请日：2018-08-15
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R' and R2 is hydrogen or deterium and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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Patent Agency Ranking
公开(公告)号：AU2014337154B2
公开(公告)日：2018-06-28
申请号：AU2014337154
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , WALDO MICHAEL , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , STROHMEIER MARK , STAVROPOULOS KATHY , KADIYALA IRINA NIKOLAEVNA , NAVAMAL METTACHIT
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R
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公开(公告)号：CA2927631C
公开(公告)日：2022-05-17
申请号：CA2927631
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： KADIYALA IRINA NIKOLAEVNA , O'NEIL SIMON ADAM , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , STAVROPOULOS KATHY , MUDUNURI PRAVEEN , SONG BIN , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME WIREDU , ZHANG YUEGANG
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：ES2802296T3
公开(公告)日：2021-01-18
申请号：ES18188034
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/14 , A61K31/506 , A61P35/00
Abstract: Un co-cristal que comprende un compuesto de fórmula **(Ver fórmula)** y un formador de co-cristal, en la que el formador de co-cristales es ácido adípico, en la que cada uno de R1 y R2 es independientemente hidrógeno o deuterio, para su uso en la potenciación de un régimen terapéutico para el tratamiento del cáncer, en la que el uso comprende administrar a un individuo que lo necesite una cantidad efectiva de dicho co-cristal, y en la que el régimen terapéutico es la radioterapia.
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公开(公告)号：SI3424920T1
公开(公告)日：2020-08-31
申请号：SI201431595
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME WIREDU , O'NEIL SIMON ADAM , ZHANG YUEGANG , MUDUNURI PRAVEEN , VAN ALSTEN JOHN GREGG , SONG BIN , STAVROPOULOS KATHY , STROHMEIER MARK , WALDO MICHAEL , NAVAMAL METTACHIT , KADIYALA IRINA NIKOLAEVNA
IPC: C07D401/00 , A61K31/00 , A61P35/00
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