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公开(公告)号：JP4790025B2
公开(公告)日：2011-10-12
申请号：JP2008554160
申请日：2007-03-14
Applicant: コリア アドバンスド インスティチュート オブ サイエンス アンド テクノロジー
CPC classification number: C12P13/08 , C12N9/1014 , C12Y201/02011
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公开(公告)号：JP2009521960A
公开(公告)日：2009-06-11
申请号：JP2008554160
申请日：2007-03-14
Applicant: コリア アドバンスド インスティチュート オブ サイエンス アンド テクノロジー
CPC classification number: C12P13/08 , C12N9/1014 , C12Y201/02011
Abstract: 本発明は、分枝鎖アミノ酸生成能が改善した変異微生物及びそれを使用した分枝鎖アミノ酸の製造方法に関するもので、より具体的には、Ｌ−イソロイシン生合成に関与する酵素をコードする遺伝子、Ｌ−ロイシン生合成に関与する酵素をコードする遺伝子及びＤ−パントテン酸生合成に関与する酵素をコードする遺伝子を弱化または欠失させて、Ｌ−バリン生合成に関与する酵素をコードする遺伝子をその発現が増加するように変異させて収得したＬ−バリン生成能が改善した変異微生物及びそれを使用したＬ−バリンの製造方法に関するものである。 部位特異的突然変異方法と代謝流れ操作によって収得された本発明による変異微生物は、分枝鎖アミノ酸、特に、Ｌ−バリンを高効率で生成することができて、Ｌ−バリンの産業的生成微生物として有用である。
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公开(公告)号：JP4229700B2
公开(公告)日：2009-02-25
申请号：JP2002561662
申请日：2002-01-18
Applicant: ビーエーエスエフ ソシエタス・ヨーロピアBasf Se
Inventor： ハーマン，セロン , パターソン，トーマス，エー． , ペロ，ジャニス，ジー． , ヨカム，アール．，ロジャーズ
IPC: C12N15/09 , C12P13/04 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/88 , C12P13/02 , C12R1/125
CPC classification number: C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
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24.发明公开MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME 审中-公开支链氨基酸提高生产能力的突变微生物及用其制备支链氨基酸的方法
公开(公告)号：EP2038403A1
公开(公告)日：2009-03-25
申请号：EP07715659.4
申请日：2007-03-14
Inventor： LEE, Sang Yup , PARK, Jin Hwan , LEE, Kwang Ho , KIM, Tae Yong
IPC: C12N1/16
CPC classification number: C12P13/08 , C12N9/1014 , C12Y201/02011
Abstract: The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site- specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.
Abstract translation: 本发明涉及具有提高的支链氨基酸生产率的突变微生物以及使用该突变微生物生产支链氨基酸的方法。 更具体地，涉及通过减弱或缺失编码参与L-异亮氨酸生物合成的酶的基因，编码参与L-亮氨酸的酶的基因和编码L-异亮氨酸生物合成酶的基因而产生的L-缬氨酸的生产率提高的突变微生物 参与D-泛酸生物合成的酶，以及编码参与L-缬氨酸生物合成的酶的基因的突变，从而增加其表达，以及使用该突变体微生物生产L-缬氨酸的方法。 通过位点特异性诱变和代谢途径工程产生的本发明的突变微生物可高效生产支链氨基酸，特别是L-缬氨酸，因此可用作生产L-缬氨酸的工业微生物。
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公开(公告)号：EP1390519B1
公开(公告)日：2006-12-06
申请号：EP02709018.2
申请日：2002-01-18
Applicant: BASF Aktiengesellschaft
Inventor： YOCUM, R., Rogers , PATTERSON, Thomas, A. , PERO, Janice, G. , HERMANN, Theron
IPC: C12N9/10 , C12N9/04 , C12P13/02 , C12N15/03 , C07C235/12
CPC classification number: C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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Patent Agency Ranking
公开(公告)号：EP1390519A2
公开(公告)日：2004-02-25
申请号：EP02709018.2
申请日：2002-01-18
Applicant: BASF AKTIENGESELLSCHAFT
Inventor： YOCUM, R., Rogers , PATTERSON, Thomas, A. , PERO, Janice, G. , HERMANN, Theron
IPC: C12P13/02 , C12N9/10 , C12N9/04 , C12N15/03 , C07C235/12
CPC classification number: C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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公开(公告)号：EP2852673B1
公开(公告)日：2017-12-06
申请号：EP13793326.3
申请日：2013-05-23
Applicant: LanzaTech New Zealand Limited
Inventor： KOEPKE, Michael , AL-SINAWI, Bakir
CPC classification number: C12N15/65 , C12N1/20 , C12N9/1014 , C12N9/88 , C12N9/93 , C12N15/52 , C12N15/74 , C12Y201/02011 , C12Y202/01011 , C12Y401/01011 , C12Y401/99017 , C12Y603/02001
Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.
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28.发明公开SELECTION METHOD AND RECOMBINANT MICROORGANISMS AND USES THEREFOR 有权AUSWAHLVERFAHREN UND REKOMBINANTE MIKROORGANISMEN SOWIE VERWENDUNGENDAFÜR
公开(公告)号：EP2852673A4
公开(公告)日：2016-03-16
申请号：EP13793326
申请日：2013-05-23
Applicant: LANZATECH NEW ZEALAND LTD
Inventor： KOEPKE MICHAEL , AL-SINAWI BAKIR
CPC classification number: C12N15/65 , C12N1/20 , C12N9/1014 , C12N9/88 , C12N9/93 , C12N15/52 , C12N15/74 , C12Y201/02011 , C12Y202/01011 , C12Y401/01011 , C12Y401/99017 , C12Y603/02001
Abstract: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the one or more gene. This permits genetic manipulations to be performed. It permits lower cost fermentations to be performed. It permits production of the essential nutrient for subsequent commodity use.
Abstract translation: 维生素或其他必需营养物质的生物合成途径中的一个或多个基因是微生物存活所必需的，可用作识别用外源核酸转化的细胞的有效选择性标记。 微生物不天然含有或表达一种或多种基因。 这允许执行遗传操作。 它允许执行较低成本的发酵。 它允许生产用于随后商品使用的必需营养物质。
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29.发明公开MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME 审中-公开FOR这样就产生支链氨基酸具有增加的产能支链氨基酸和方法微生物突变
公开(公告)号：EP2038403A4
公开(公告)日：2009-12-30
申请号：EP07715659
申请日：2007-03-14
Applicant: KOREA ADVANCED INST SCI & TECH
Inventor： LEE SANG YUP , PARK JIN HWAN , LEE KWANG HO , KIM TAE YONG
CPC classification number: C12P13/08 , C12N9/1014 , C12Y201/02011
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公开(公告)号：NO20033240A
公开(公告)日：2003-09-17
申请号：NO20033240
申请日：2003-07-17
Applicant: BASF AG
Inventor： YOCUM R ROGERS , PATTERSON THOMAS A , PERO JANICE G , HERMANN THERON
IPC: C12N15/09 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/10 , C12N9/88 , C12P13/02 , C12P13/04 , C12R1/125 , C12P13/025 , C12N1/20
CPC classification number: C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
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