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    APPARATUS AND METHODS FOR ANALYZING THE OUTPUT OF MICROFLUIDIC DEVICES
    22.
    发明公开
    APPARATUS AND METHODS FOR ANALYZING THE OUTPUT OF MICROFLUIDIC DEVICES 审中-公开
    用于分析微流体装置的输出的设备和方法

    公开(公告)号：EP3180600A1

    公开(公告)日：2017-06-21

    申请号：EP15831303.1

    申请日：2015-08-14

    Applicant: The Trustees of The University of Pennsylvania

    Inventor： ISSADORE, David ,  WOLDERMARIAM, Melaku Muluneh

    IPC: G01N21/63

    CPC classification number: G01N21/6428 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0861 ,  G01N2201/063

    Abstract: Microfluidic devices for analyzing droplets are disclosed. A described microfluidic device includes a substrate and a microfluidic channel formed on the substrate. The microfluidic channel includes passages where each passage has a mask pattern configured to modulate a signal of a droplet passing through that passage, such that droplets passing through the passages produce signals. The microfluidic device also includes a detector configured to detect the signals. Methods of analyzing droplets with a microfluidic device having a microfluidic channel formed on a substrate are disclosed. A described method includes passing droplets through the passages, modulating signals from the droplets using mask patterns, formed on the passages; and detecting the signals.

    Abstract translation: 公开了用于分析液滴的微流体装置。 所描述的微流体装置包括基底和形成在基底上的微流体通道。 微流体通道包括通道，其中每个通道具有掩模图案，该掩模图案被配置为调制通过该通道的液滴的信号，使得通过通道的液滴产生信号。 微流体装置还包括配置成检测信号的检测器。 公开了用微流体装置分析微滴的方法，所述微流体装置具有在基底上形成的微流体通道。 所描述的方法包括使液滴通过通道，使用形成在通道上的掩模图案来调制形成液滴的信号; 并检测信号。

    IRIS CONTROL SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES
    24.
    发明公开
    IRIS CONTROL SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
    光圈控制系统可用于生物样品细菌IDENTIFYING

    公开(公告)号：EP2668257A2

    公开(公告)日：2013-12-04

    申请号：EP12739232.2

    申请日：2012-01-25

    Applicant: Pocared Diagnostics Inc.

    Inventor： INGBER, Gal

    IPC: C12M1/34 ,  C12M1/42 ,  C12M1/12 ,  C12Q1/04

    CPC classification number: G01N21/07 ,  G01N21/31 ,  G01N2201/063

    Abstract: A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical cup for measuring the intensity level of the excitation wavelength, and feeding this information to an iris having an iris setting control device such that the iris setting may be adjusted based upon the measured intensity level to control and optimize the level of light fed to the filter wheel from the lamp. The iris setting can be adjusted so that the level of light fed to the filter wheel remains constant during the lifetime of the lamp and to ensure that the level of light fed to the sample remains below the level at which photo-bleaching occurs.

    CONFOCAL INSPECTION SYSTEM HAVING NON-OVERLAPPING ANNULAR ILLUMINATION AND COLLECTION REGIONS
    26.
    发明申请
    CONFOCAL INSPECTION SYSTEM HAVING NON-OVERLAPPING ANNULAR ILLUMINATION AND COLLECTION REGIONS 审中-公开
    具有非重叠照明和收集区域的共焦检查系统

    公开(公告)号：WO2016106350A1

    公开(公告)日：2016-06-30

    申请号：PCT/US2015/067445

    申请日：2015-12-22

    Applicant: BRIBBLA DYNAMICS LLC

    IPC: G02B21/00 ,  G02B21/08

    CPC classification number: G02B21/0032 ,  G01N21/49 ,  G01N21/55 ,  G01N2201/063 ,  G02B21/006 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/084 ,  G02B21/10 ,  G02B21/16

    Abstract: A confocal inspection system can optically characterize a sample. An objective lens, which can be a single lens or a combination of separate illumination and collection lenses, can have a pupil. The objective lens can deliver incident light to the sample through an annular illumination region of the pupil, and can collect scattered light returning from the sample to form collected light. Confocal optics can be positioned to receive the collected light. A detector can be configured with the confocal optics so that the detector generates signals from light received from a specified depth at or below a surface of the sample and rejects signals from light received from depths away from the specified depth. An optical element, such as a mask, a reconfigurable panel, or the detector, can define the annular collection region to be non-overlapping with the annular illumination region in the pupil.

    Abstract translation: 共焦检查系统可以光学地表征样品。 可以是单个透镜或单独的照明和收集透镜的组合的物镜可以具有瞳孔。 物镜可以通过瞳孔的环形照明区域向样品传送入射光，并且可以收集从样品返回的散射光以形成收集的光。 可以将共焦光学器件定位成接收收集的光。 检测器可以配置有共聚焦光学器件，使得检测器从从样品表面上或下面的指定深度接收的光产生信号，并从远离指定深度的深度接收的光中拒绝信号。 诸如掩模，可重构面板或检测器的光学元件可以限定与瞳孔中的环形照明区域不重叠的环形收集区域。

    SPECTROMÈTRE POUR L'ANALYSE DU SPECTRE D'UN FAISCEAU LUMINEUX
    27.
    发明申请
    SPECTROMÈTRE POUR L'ANALYSE DU SPECTRE D'UN FAISCEAU LUMINEUX 审中-公开
    用于分析光束光谱的光谱仪

    公开(公告)号：WO2014087081A1

    公开(公告)日：2014-06-12

    申请号：PCT/FR2013/052900

    申请日：2013-11-29

    Applicant: HORIBA JOBIN YVON SAS

    Inventor： ACHER, Olivier ,  RICHARD, Simon ,  BRACH, Christian ,  MILLET, Viviane ,  CORDE, Sébastien ,  HERAN, Daphné

    IPC: G01J3/02 ,  G01J3/18 ,  G01J3/447 ,  G02B5/18 ,  G02B27/28

    CPC classification number: G01N21/645 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/18 ,  G01J3/447 ,  G01N2201/063 ,  G01N2201/0633 ,  G02B5/1866 ,  G02B27/283

    Abstract: La présente invention concerne un spectromètre (100) pour l'analyse du spectre d'un faisceau lumineux amont (1) comportant une fente d'entrée (101), des moyens de collimation (110) adaptés à générer, à partir du faisceau lumineux amont, un faisceau lumineux collimaté (10), caractérisé en ce qu'il comprend également : - un réseau de diffraction à séparation de polarisation (120) adapté à diffracter pour chaque longueur d'onde (l1, l2) du spectre du faisceau lumineux amont le faisceau lumineux collimaté en un premier faisceau lumineux diffracté (11, 12) et en un deuxième faisceau lumineux diffracté (21, 22), - des moyens optiques de recombinaison (130) comprenant une surface plane de réflexion optique (130) perpendiculaire au réseau adaptée à dévier au moins le deuxième faisceau lumineux diffracté, et - des moyens de focalisation (140) adaptés pour focaliser, à chaque longueur d'onde, le premier faisceau lumineux diffracté et le deuxième faisceau lumineux diffracté sur une même surface de focalisation (141).

    Abstract translation: 本发明涉及一种用于分析上游光束（1）的光谱的光谱仪（100），包括入射狭缝（101）和适于从上游光束产生准直光束的准直装置（110） （10），其特征在于还包括：偏振相关衍射光栅（120），适于在上游光束的光谱的每个波长（11,12）处衍射，将准直光束衍射成第一衍射光 光束（11,12）和第二衍射光束（21,22）; 光学重组装置（130），其包括垂直于光栅的平面光学反射表面（130），并且适于至少偏离第二衍射光束; 以及适于在每个波长处将第一衍射光束和第二衍射光束聚焦到同一聚焦区域（141）上的聚焦装置（140）。

    ILLUMINATION TECHNIQUES FOR SAMPLES
    29.
    发明公开
    ILLUMINATION TECHNIQUES FOR SAMPLES 审中-公开

    公开(公告)号：EP3336523A1

    公开(公告)日：2018-06-20

    申请号：EP16204148.7

    申请日：2016-12-14

    Applicant: F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    Inventor： WIETZORREK, Joachim

    IPC: G01N21/64 ,  G02B21/06

    CPC classification number: G01N2021/6463 ,  G01N2201/063 ,  G01N2201/0631 ,  G02B21/06

    Abstract: In one aspect of the present disclosure, an illumination system for a sample includes a sample plane in which a sample to be illuminated can be arranged, an illumination device arranged to illuminate a sample in the sample plane, the illumination device being arranged in a Koehler configuration, the illumination device comprising a light source, optics arranged to guide light from the light source to the sample plane, a homogenizer disposed between the light source and the optics having an input face for receiving light from the light source and an output face for outputting light towards the optics, the homogenizer being configured to provide a spatially and angularly homogeneous output light distribution.

    A POLARIZED LIGHT IMAGING APPARATUS AND METHODS THEREOF FOR SEPARATING LIGHT FROM A SURFACE OF A SAMPLE ITS DEEPER DIFFUSE LAYERS
    30.
    发明公开
    A POLARIZED LIGHT IMAGING APPARATUS AND METHODS THEREOF FOR SEPARATING LIGHT FROM A SURFACE OF A SAMPLE ITS DEEPER DIFFUSE LAYERS 审中-公开
    的装置上使用偏振光和方法，用于与更深扩散层从样品的表面的光的分离的成像

    公开(公告)号：EP2989441A4

    公开(公告)日：2017-02-22

    申请号：EP14787525

    申请日：2014-04-20

    Applicant: MOBILEOCT LTD

    Inventor： LEVITZ DAVID ,  BEERY ARIEL K

    IPC: G01N21/21 ,  G01N21/956

    CPC classification number: G01N21/21 ,  G01N21/956 ,  G01N2201/063

    Abstract: A polarized light imaging apparatus for separating light from a superficial single-scattering layer of a sample and its deeper diffuse layer as a function of space is disclosed. The apparatus has a light source for producing light beams; an illumination optic coupled to the light source for guiding the light beams towards the sample; a linear polarizer coupled to the illumination optic; a non-total internal reflection (TIR) birefringent polarizing prism (BPP) communicatively coupled to the sample to maximize a refraction difference between ordinary waves and extraordinary waves of light returning from the sample; and a detection optic unit coupled to the non-TIR BPP for guiding the light waves returning from the sample towards a single polarization sensitive sensor element.

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