公开(公告)号：EP0123178A3

公开(公告)日：1985-08-14

申请号：EP84103733

申请日：1984-04-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N21/07 ,  B04B05/04

CPC classification number: G01N21/07

Abstract: Analytical photometer for the practically simultaneous determination of the presence of different substances in a certain number of discrete samples. The photometer (10) is equipped with a centrifugal type rotor (16), already known in the art, containing a large number of chambers with inlet holes (20, 22) for the sample/samples and reagents and with axially aligned transparent windows, thereby forming a system of rotating cuvettes (18). The rotor compartments (16) serve as receptacles for the solutions and are designed and dimensioned as already known in the art, such as to retain the liquid when said rotor (16) is at rest and to transfer said liquid into the cuvettes (18) when the rotor (16) rotates. A single or multiple light source (L) is provided, which is transmitted in a novel manner through a system of suitable means, in particular, optical fibres (30-35) to various photodetector units (60 to 65), suitably aligned with the transparent windows of the cuvettes (18) by means of the same number of interference filters (50to 55) and appropriate holes (40 to 45) situated in the base (15) of the rotor (16). Thus it is possible to determine for the first time, concentrations of chemical solutions through the absorbance in the sample/samples plus reagent/reagents contained in the cuvettes (18) at various wave lengths, with wave energy being delivered from source (L). Hence it is possible to examine more than one cuvette (18) almost simultaneously and singly, each one for a different analytical parameter, and consequently to examine the transmittance and/or absorbance of the samples contained in the cuvettes at optimum wave length.

公开(公告)号：EP0070156A3

公开(公告)日：1984-06-20

申请号：EP82303591

申请日：1982-07-08

Applicant: HAEMONETICS CORPORATION

Inventor： Latham, Allen, Jr. ,  Schoendorfer, Donald W.

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  B04B13/00 ,  Y10T137/108 ,  Y10T137/1098

Abstract: Centrifuge apparatus includes a timing and control mechanism including a piston (10) to which is attached a cam (39, 51) having cam surfaces (5) which interact with flexible tubing (36) to control the rate of flow of blood through the tubing. The velocity of the piston (10) in the centrifugal force field of rotor (34) is determined by the resistance to flow of a viscous oil which the piston displaces with cylinder (12) Figure 5. The movement of the cam (39, 51) is, therefore, a measure of the magnitude and duration of the centrifugal force acting to process the blood.

公开(公告)号：EP0058436A3

公开(公告)日：1984-05-23

申请号：EP82102419

申请日：1980-02-26

Applicant: TERUMO CORPORATION

Inventor： Kobayashi, Susumu

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  B04B5/02

Abstract: The present invention concerns a fluid processing device with conduits for centrifugal separating of a fluid, comprising: a container (33) rotatable about a rotary axis and a plurality of tubes (37a, 38a, 39a) located on the rotary axis of the container (33), affixed to an upper opening of the container (33) and hermetically sealed and opening ends of which are located at positions differing from one another from the top to the bottom of the container (33); and flexible conduits (37-40) are attached to the other opening ends of the tubes for feeding a fluid and for discharging separated fluid fractions, respectively.

公开(公告)号：WO1996011747A2

公开(公告)日：1996-04-25

申请号：PCT/US1995013447

申请日：1995-10-10

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION ,  HEADLEY, Thomas, D. ,  POWERS, Edward, T.

Inventor： TRANSFUSION TECHNOLOGIES CORPORATION ,  HEADLEY, Thomas, D. ,  POWERS, Edward, T.

IPC: B04B05/04

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: A rotor (2a-2e) for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm (31) which defines at least a portion of a variable-volume processing chamber (30), where the fluid is centrifuged. The rotor includes a rigid mounting member (28), to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall (10) which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit (13) or conduits (83, 93, 163, 165, 188) to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure (40, 190, 244) for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate (40), located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes (190), wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves (244) in the boundary wall may be used as the outlet-control structure.

Abstract translation: 一种用于在一定体积范围内收集和离心生物流体的转子（2a-2e）。 转子包括限定至少一部分可变体积的处理室（30）的弹性不透水隔膜（31），其中流体被离心。 转子包括刚性安装构件（28），隔膜安装在该刚性安装构件（28）上并由卡盘保持和旋转。 优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁（10）。 边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管（13）或导管（83,93,163,165,188） 以便与处理室流体连通。 转子可以包括用于控制液体流出腔室进入管道的单独结构（40,190,244）。 在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的基本刚性的壁或板（40）。 在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管（190），其中每个管提供腔室和管道之间的流体连通。 在一个优选实施例中，边界壁中的凹槽（244）可用作出口控制结构。

公开(公告)号：WO1994008721A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009276

申请日：1993-09-29

Applicant: HAEMONETICS CORPORATION

Inventor： HAEMONETICS CORPORATION ,  HEADLEY, Thomas, D. ,  CHAMMAS, Jacques

IPC: B04B05/04

CPC classification number: B04B5/0442 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0407 ,  B04B7/08 ,  B04B2005/0464

Abstract: An improved centrifuge rotor formed of a bowl body (12) and core (8) for blood processing applications, such as cell washing or pheresis, is described. A tubular core (8) adapted to rotate with the rotor defines a processing region between the core (8) and the interior of the bowl (12) body. A plurality of projections (4) extend into the processing region to minimize formation of fluid Coriolis waves which would otherwise cause undesirable turbulence.

Abstract translation: 描述了由用于血液处理应用的碗体（12）和芯（8）形成的改进的离心机转子，例如细胞洗涤或去血浆。 适于与转子一起旋转的管状芯部（8）限定了芯部（8）和碗状物（12）内部之间的加工区域。 多个突起（4）延伸到处理区域中以最小化流体科里奥利波的形成，否则这将导致不期望的湍流。

公开(公告)号：WO1992000145A1

公开(公告)日：1992-01-09

申请号：PCT/SE1991000463

申请日：1991-06-26

Applicant: OMEGA TEKNIK HB ,  UNGER, Peter ,  WESTBERG, Eric

Inventor： OMEGA TEKNIK HB

IPC: B04B05/04

CPC classification number: B04B5/0428 ,  A61M1/0209 ,  A61M1/029 ,  A61M1/3693 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2005/1404 ,  B04B2005/0435

Abstract: The present invention relates to a method and to a device for separating blood present in a blood container (1) into components (34, 36, 35) by centrifuging the blood, and for transmitting at least one of three stratified components (34, 35) obtained by centrifugation in sterile fashion to a respective side container (2, 3) connected to the blood container (1) via a respective hose (4, 5). The fluid-actuatable displacement body (17) and the blood container (1) are placed in a cassette (12, 13) which, in turn, can be placed in a centrifuge cup (25). The displacement body (17) is in direct abutment with the blood container (1). The displacement body (17) surrounds half the blood container (1) and when fluid is delivered to the body, it will preferably expand, firstly at its lower part and then successively upwards. The cassette (12, 13) is preferably placed in one of two compartments (27) of an intermediate container (24), the other compartment (41) being intended to accommodate the side container (2 and 3 respectively).

Abstract translation: 本发明涉及通过离心血液将存在于血液容器（1）中的血液分离成组分（34,36,35）的装置，以及用于传送三个分层组分（34,35）中的至少一个 ）通过以无菌方式离心到经由相应的软管（4,5）连接到血液容器（1）的相应侧容器（2,3）获得。 流体致动位移体（17）和血液容器（1）被放置在盒（12,13）中，其又可以放置在离心杯（25）中。 位移体（17）与血液容器（1）直接抵接。 位移体（17）围绕血液容器（1）的一半并且当流体被输送到身体时，优选地首先在其下部扩张，然后依次向上膨胀。 盒（12,13）优选地放置在中间容器（24）的两个隔室（27）中的一个中，另一隔室（41）旨在容纳侧容器（2和3）。

公开(公告)号：WO1991015300A1

公开(公告)日：1991-10-17

申请号：PCT/SE1991000226

申请日：1991-03-25

Applicant: OMEGA TEKNIK HB ,  UNGER, Peter ,  WESTBERG, Eric

Inventor： OMEGA TEKNIK HB

IPC: B04B05/04

CPC classification number: A61M1/3693 ,  A61M1/3696 ,  B04B5/0442 ,  B04B2005/0492

Abstract: Centrifuge arrangement preferably intended for separation of blood and arranged for through-flow separation comprising a number of channels (4-7) for collection of at least two fractions, whereby said channels are connected to, or are arranged to be able to be connected to, an inlet (25) for the liquid which is to be fractionated and to one or more outlets (24, 26, 27) for respective fractions, whereby means are arranged to segregate at least one collection channel (e.g. 6 or 7) from other channels along at least a portion of its length, together with means for intermittently withdrawing the fraction collected in this channel. The described arrangement is characterized in that the segregatable channel is separated from remaining channels by means of one or more gaps (8, 9, 54a, 54b, 56) which are so small that an appreciable pressure difference results between this channel and remaining channels when the fraction collected in this channel is withdrawn.

Abstract translation: 离心机布置优选地用于分离血液并且被布置成用于通流分离，包括用于收集至少两个级分的多个通道（4-7），由此所述通道连接到或被布置成能够连接到 ，用于分馏的液体的入口（25）和用于各个部分的一个或多个出口（24,26,27），其中装置被布置成将至少一个收集通道（例如6或7）与其他部分分离 沿其长度的至少一部分的通道，以及用于间歇地取出在该通道中收集的级分的装置。 所描述的布置的特征在于，通过一个或多个间隙（8,9,5a，54b，56）将可分离通道与剩余通道分离，这些间隙太小，使得在该通道和剩余通道之间产生明显的压力差， 在该通道中收集的馏分被取出。

公开(公告)号：WO1990005590A1

公开(公告)日：1990-05-31

申请号：PCT/SU1989000280

申请日：1989-11-13

Applicant: INSTITUT MOLEKULYARNOI BIOLOGII IMENI V.A.ENGELGA ,  BERITASHVILI, David Revazovich ,  GEORGIEV, Georgy Pavlovich ,  GROSS, Valery Nikolaevich

Inventor： INSTITUT MOLEKULYARNOI BIOLOGII IMENI V.A.ENGELGA

IPC: B04B05/04

CPC classification number: B04B5/0414 ,  B04B2007/025

Abstract: The centrifuge comprises a rotor (1) with a vertical rotation axis (O1-O1). In the rotor (1) is mounted at least one receptacle (2) with an extended separation cavity (3), the longitudinal axis (O2-O2) of which is inclined in relation to the rotation axis (O1-O1) of the rotor (1). A part (4) of the separation cavity (3), peripheral in relation to the rotation axis (O1, O1) of the rotor (1), is located above its part (5) neighbouring the rotation axis (O1-O1) of the rotor (1). In the receptacle (2) is provided a chamber (7) for collecting the settled particles, which is located lower and further than the peripheral part (4) of the separation cavity (3) and is connected with the latter.

Abstract translation: 离心机包括具有垂直旋转轴线（O1-O1）的转子（1）。 在转子（1）中安装至少一个具有延伸分离腔（3）的容器（2），其纵轴（O2-O2）相对于转子的旋转轴线（O1-O1）倾斜 （1）。 分离腔（3）的与转子（1）的旋转轴线（O1，O1）相对的周边的部分（4）位于与转子（1）的旋转轴线（O1，O1）相邻的部分 转子（1）。 在容器（2）中设置有用于收集沉降的颗粒的室（7），所述沉降颗粒位于分隔空腔（3）的下部并且远离分隔空腔（3）的周边部分（4）并与其连接。

公开(公告)号：WO1987003512A1

公开(公告)日：1987-06-18

申请号：PCT/US1986002240

申请日：1986-10-23

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SHARPLES, Thomas, D. ,  PIRAMOON, Alireza

IPC: B04B05/04

CPC classification number: B04B5/0421

Abstract: A swinging bucket centrifuge rotor including seating surfaces having shapes which cause buckets seating thereon to be relieved of side loading forces. Each bucket is symmetrical and is pivotally supported by bucket pins that rest in respective spring-loaded carrier assemblies. The spring constants of the springs of the carrier assemblies are selected so that the leading edge of each bucket bottom rests upon a curved surface and clears the respective seating surface before the trailing edge thereof contacts the same. The resulting bucket orientation assures that, upon seating, each bucket rotates until its bucket pins lift slightly off of the surfaces of the respective carrier assemblies.

公开(公告)号：WO1985005569A1

公开(公告)日：1985-12-19

申请号：PCT/US1985001040

申请日：1985-06-03

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SUTTON, John, H. III ,  CHULAY, Steven, J.

IPC: B04B05/04

CPC classification number: B04B5/0421

Abstract: A centrifuge rotor (10) which comprises a rotor (10) having a plurality of radially extending arms (21), having a construction to matably receive a pin structure (32) within a recess (29) formed in the upper surface (26) of the rotor (10), to support the pin structure (32) against loads generated by centrifugal force without stressing a fastener (42). In assembly, the pin structures (32) permanently mount trunnions (58) for receiving a sample container (22), for pivotal movement, in a manner such that the trunnion (58) and sample container (22) cooperate to resist stresses and deformation caused by centrifugal loads.