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    STABLE ISOSORBIDE NITRATE COMPOSITION AND ITS PREPARATION
    295.
    发明专利
    STABLE ISOSORBIDE NITRATE COMPOSITION AND ITS PREPARATION 失效

    公开(公告)号：JPS60181052A

    公开(公告)日：1985-09-14

    申请号：JP3618084

    申请日：1984-02-29

    Applicant: TOA EIYO LTD

    Inventor： NARA TAKESHI ,  HAYASHI HISASHI ,  SATOU KENTAROU

    IPC: C07C201/02 ,  C07C67/00 ,  C07C201/00 ,  C07C201/16 ,  C07C203/02 ,  C07C203/04

    Abstract: PURPOSE:To provide the titled composition having high stability and handleability, free from irritation and volatility, and effective as a remedy and preventive for the fit of stenocardia, by compounding isosorbide nitrate with a specific component such as polyvinyl pyrrolidone. CONSTITUTION:Isosorbide nitrate is compounded with one or more components selected from the group of polyvinyl pyrrolidone, methyl-cellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose. The amount of the latter component is 0.2-30pts.wt., especially 1-15pts.wt. per 1pt.wt. of isosorbide nitrate. The composition is prepared preferably by dissolving isosorbide nitrate in a solvent, and then dissolving and/or dispersing the latter component such as polyvinyl pyrrolidone in the solution, however, it may be prepared by mixing the solution or dispersion of isosorbide nitrate with the of the latter component.

    PRODUCTION OF 2-NITRATOPROPANOL
    296.
    发明专利
    PRODUCTION OF 2-NITRATOPROPANOL 失效

    公开(公告)号：JPS60152445A

    公开(公告)日：1985-08-10

    申请号：JP886884

    申请日：1984-01-20

    Applicant: TAISHO PHARMA CO LTD

    Inventor： NAKAJIMA YOSHIMOTO ,  OGAWA TOSHIHISA ,  NAKAZATO ATSUO ,  KUMAZAWA YUKINARI ,  SODA KAORU

    IPC: C07C203/04 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02

    Abstract: PURPOSE:To obtain the titled compound useful as an intermediate of pharmaceuticals, easily, in high purity, without producing hardly separable position isomers, by reducing a lower alkyl ester of 2-nitratopropionic acid with a reducing agent. CONSTITUTION:The objective compound can be produced without producing a position isomer, 2-nitrato-2-propanol, by reducing 2-nitratopropionic acid lower alkyl ester (1-3C alkyl ester) with a borohydride reducing agent (e.g. NaBH4, NaBH4-CaCl2) at 40-70 deg.C, or with aluminum hydride reducing agent (e.g. LiAl H4) in an inert solvent at -50-0 deg.C. The most suitable reducing agent is NaBH4- CaCl2. Since the production of impurity is little, highly purified objective product can be produced easily in high yield.

    PREPARATION OF MONONITROCHLOROBENZENE
    297.
    发明专利
    PREPARATION OF MONONITROCHLOROBENZENE 失效

    公开(公告)号：JPS5896044A

    公开(公告)日：1983-06-07

    申请号：JP19177281

    申请日：1981-12-01

    Applicant: MITSUI TOATSU CHEMICALS

    Inventor： TAKENAKA SHINJI ,  NISHIDA TAKESHI ,  KANEMOTO YOSHIO

    IPC: B01J27/00 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/08 ,  C07C205/12

    Abstract: PURPOSE:To prepare the titled compound useful as an intermediate of dyes, etc., in a short time, in high yield, suppressing the by-production of dinitro compounds, by nitrating chlorobenzene using a nitrating agent comprising a mixture of nitric acid and a concentrated phosphoric acid having specific concentration, at a specific temperature. CONSTITUTION:Mononitrochlorobenzene is prepared in an yield of as high as >=98%, by adding a mixed acid consisting of 98% nitric acid and concentrated phosphoric acid having a concentration of >=72.4wt%, preferably 74-80wt% in terms of P2O5 dropwise to chlorobenzene at 50-120 deg.C, preferably 60-100 deg.C to effect the nitration reaction. The concentrated phosphoric acid can be prepared easily by concentrating ordinary orthophosphoric acid by evaporation, e.g. at 150 deg.C and 20mm.Hg. USE:Intermediate of agricultural chemicals and other industrial chemicals.

    PROCESS FOR THE MANUFACTURE OF NICORANDIL
    299.
    发明申请
    PROCESS FOR THE MANUFACTURE OF NICORANDIL 审中-公开
    尼古丁制造工艺

    公开(公告)号：WO2012089769A1

    公开(公告)日：2012-07-05

    申请号：PCT/EP2011/074152

    申请日：2011-12-28

    Applicant: PROCOS S.P.A. ,  BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

    Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

    IPC: C07C201/02

    CPC classification number: C07C201/02 ,  C07C203/04

    Abstract: Disclosed is a process for the synthesis of Nicorandil (1), 2-(nicotinamide)ethyl nitrate, starting from N-(2-hydroxyethyl)nicotinamide (15), using nitration with nitric acid in the presence of acetic anhydride Said synthesis method is particularly advantageous because it solves the safety problems involved in the use of nitric acid as nitrating agent, and allows a product with excellent yields and quality to be isolated.

    Abstract translation: 公开了一种从N-（2-羟乙基）烟酰胺（15）开始合成尼可地尔（1），2-（烟酰胺）乙酸乙酯的方法，使用硝酸在乙酸酐存在下硝化所述合成方法为 特别有利，因为它解决了使用硝酸作为硝化剂所涉及的安全问题，并且能够分离出优异的产率和质量的产品。

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