公开(公告)号：US09488581B2

公开(公告)日：2016-11-08

申请号：US14444218

申请日：2014-07-28

Applicant: Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG

Inventor： Andreas Lobbert ,  Ronny Michael ,  Christian Fanselow

IPC: G01N21/64 ,  G01J1/44 ,  G01N21/77 ,  G01J1/04 ,  G01N21/78 ,  G01N21/80

CPC classification number: G01N21/645 ,  G01J1/0425 ,  G01J1/44 ,  G01N21/77 ,  G01N21/78 ,  G01N21/783 ,  G01N21/80 ,  G01N2021/6432 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An arrangement for optical measurement of at least one process variable in a medium, comprising: at least one light source; at least one light receiver; an optical sensor element at least one data processing unit; and a light conductor. The light conductor connects the light source with the optical sensor element and the optical sensor element with the light receiver. The light conductor is embodied with at least three arms, wherein the first arm is arranged at the light source, the second arm is arranged at the light receiver and the third arm is arranged at the optical sensor element first arm and the second arm combine to form the third arm. The invention relates further to a measuring device comprising an above described arrangement.

Abstract translation: 一种用于光学测量介质中的至少一个过程变量的装置，包括：至少一个光源; 至少一个光接收器; 光学传感器元件至少一个数据处理单元; 和光导体。 光导体将光源与光学传感器元件和光学传感器元件与光接收器连接。 光导体具有至少三个臂，其中第一臂布置在光源处，第二臂布置在光接收器处，并且第三臂布置在光学传感器元件第一臂处，并且第二臂组合到 形成第三臂。 本发明进一步涉及包括上述布置的测量装置。

公开(公告)号：US20160238532A1

公开(公告)日：2016-08-18

申请号：US14899536

申请日：2014-06-20

Applicant: INVENIO IMAGING INC.

Inventor： Christian Wilhelm FREUDIGER ,  Jay Kenneth TRAUTMAN

IPC: G01N21/64 ,  G01N21/65

CPC classification number: G01N21/6458 ,  G01N21/6402 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/0826 ,  G02B21/0032 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/16 ,  H01S3/0672 ,  H01S3/06754

Abstract: The present disclosure provides systems and methods for performing multi-photon imaging using a fiber laser. Systems and methods herein may be used for performing imaging using multi-photon excitation (e.g., using two-photon excitation or multi-color two-photon excited fluorescence). Aspects of the disclosure are applicable to a variety of multi-photon methods without being limited to CRS or multi-photon fluorescence excitation. A multi-wavelength fiber laser system and its use in multi-photon methods are provided.

Abstract translation: 本公开提供了使用光纤激光器执行多光子成像的系统和方法。 本文的系统和方法可以用于使用多光子激发（例如，使用双光子激发或多色双光子激发荧光）进行成像。 本公开的方面适用于多种多光子方法，而不限于CRS或多光子荧光激发。 提供了一种多波长光纤激光系统及其在多光子方法中的应用。

公开(公告)号：US09389167B2

公开(公告)日：2016-07-12

申请号：US14873036

申请日：2015-10-01

Applicant: Laxco, Inc.

Inventor： Cong Liang Chen ,  Kevin Cassady

IPC: G01N21/01 ,  G01N21/03 ,  G01N21/17 ,  G02B6/04 ,  G01N21/25 ,  G01N21/27 ,  G02B6/32 ,  F21V8/00 ,  G02B6/293 ,  G01N21/64

CPC classification number: G01N21/0303 ,  G01N21/01 ,  G01N21/17 ,  G01N21/253 ,  G01N21/27 ,  G01N21/6452 ,  G01N2201/0639 ,  G01N2201/08 ,  G01N2201/0826 ,  G02B6/006 ,  G02B6/04 ,  G02B6/29388 ,  G02B6/32

Abstract: An analytical instrument may have multiple distinct channels. Such may include one or more illumination sources and sensors. Illumination may be delivered to specific locations of a specimen holder, and returned illumination may be delivered to specific locations of a sensor array. Illumination may first pass a specimen, and a mirror or reflector may then return the illumination past the specimen. Optical splitters may be employed to couple pairs of fiber optics proximate a specimen holder. Such channels may further include a plurality of illumination sources positioned on one side of a specimen holder and a plurality of sensors on the other side. The plurality of sensor may capture image of a specimen and a spectrophotometer may concurrently scan the specimen. A plurality of specimens may be imaged and scanned in a single pass of a plurality of passes. Spherical or ball lenses may be placed in an optical path of the illumination to achieve a desired illumination pattern.

公开(公告)号：US09377388B2

公开(公告)日：2016-06-28

申请号：US13108713

申请日：2011-05-16

Applicant: David R. Walt ,  Karri Lynn Michael-Ballard

Inventor： David R. Walt ,  Karri Lynn Michael-Ballard

IPC: C12Q1/68 ,  G01N15/14 ,  B01J19/00 ,  B82Y30/00 ,  G01N21/64 ,  G01N33/543 ,  C40B40/06 ,  C40B40/10 ,  G01N35/00

CPC classification number: G01N15/1456 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/7703 ,  G01N21/78 ,  G01N33/543 ,  G01N33/54313 ,  G01N2015/1438 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2035/0097 ,  G01N2201/0826 ,  Y02A50/55 ,  Y10S435/808 ,  Y10S436/805

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.

公开(公告)号：US09029161B2

公开(公告)日：2015-05-12

申请号：US13808249

申请日：2011-07-11

Applicant: Maurice Aalders ,  Rolf Bremmer

Inventor： Maurice Aalders ,  Rolf Bremmer

IPC: G01N33/72 ,  G01N33/48 ,  G01N21/25 ,  G01J3/02 ,  G01J3/50 ,  G01J3/51 ,  G01N21/31 ,  G01N21/47

CPC classification number: G01N21/25 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/501 ,  G01J3/513 ,  G01N21/31 ,  G01N21/474 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.

Abstract translation: 用于测量身体样品（例如血液）的方法和装置包括在具有对应于样品中存在的至少两种预定物质的光谱中的至少两个预定位置处进行样品的至少一次光谱测量，该预定物质具有 时间变化的关系。 然后从测量中确定每种预定物质的测量相对浓度，并将两种预定物质的测量相对浓度与两种预定物质相对浓度随时间的已知变化进行比较。 然后确定测量的相对浓度与相对浓度的已知变化的良好拟合，以提供样品的年龄的指示。 或者，代替测定每种预定物质的相对浓度，确定相对浓度的变化率。

公开(公告)号：US20150119722A1

公开(公告)日：2015-04-30

申请号：US14565960

申请日：2014-12-10

Applicant: OLYMPUS CORPORATION

Inventor： Yoshioki Kaneko

IPC: A61B5/00 ,  G01N21/64 ,  G02B21/16 ,  A61B1/06

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0661 ,  A61B5/415 ,  A61B5/4227 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/0826 ,  G02B21/16 ,  G02B21/365 ,  G02B2207/113 ,  G06T7/0012 ,  G06T2207/10068 ,  G06T2207/30024

Abstract: An image processing apparatus includes: an image acquiring unit configured to acquire image information representing an image acquired by irradiating a gland duct with excitation light and observing fluorescence generated in the gland duct; a fluorescence intensity computation unit configured to compute a value corresponding to intensity of the fluorescence as fluorescence intensity based on the image information; and an image determination unit configured to determine whether or not an endocrine cell exists in the gland duct based on the fluorescence intensity computed by the fluorescence intensity computation unit, and to determine abnormality of the gland duct based on a determination result of the endocrine cell.

Abstract translation: 一种图像处理装置，包括：图像获取单元，被配置为获取表示通过用激发光照射腺体管获得的图像的图像信息，并观察在腺体管中产生的荧光; 荧光强度计算单元，被配置为基于所述图像信息计算与所述荧光强度对应的值作为荧光强度; 以及图像判定单元，其基于由所述荧光强度计算单元计算的荧光强度来判定所述腺体管内是否存在内分泌细胞，并根据所述内分泌细胞的判定结果来确定所述腺体管的异常。

公开(公告)号：US20150085290A1

公开(公告)日：2015-03-26

申请号：US14398350

申请日：2013-05-03

Applicant: FRAS Technology

Inventor： Sølve Fjerdingstad

IPC: G01N21/49 ,  G01N21/05

CPC classification number: G01N21/49 ,  G01M3/06 ,  G01N1/2035 ,  G01N15/0227 ,  G01N21/05 ,  G01N21/474 ,  G01N21/532 ,  G01N21/85 ,  G01N21/8507 ,  G01N2001/2071 ,  G01N2021/4742 ,  G01N2021/8557 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/08 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/084

Abstract: The embodiments herein relate to a system (100) for analyzing a fluid (103). The system (100) comprises a light source (110) configured to emit light for transmission through a first optical transmission means (107a) to a measurement device (105). The measurement device (105) comprises at least a part of the fluid (103) and is configured to be illuminated by the emitted light. The system comprises a second optical transmission means (107b) configured to transmit shadowed or reflected light from the fluid (103) when the measurement device (105) is illuminated to an image capturing device. The image capturing device (113) is configured to capture an image of the fluid (103) in the measurement device (105) based on the transmitted information about the fluid (103). The light source (110) and the one or more image capturing device (113) are remotely arranged from the at least one measurement device (105).

Abstract translation: 本文的实施例涉及用于分析流体（103）的系统（100）。 系统（100）包括被配置为发射光以通过第一光传输装置（107a）传输到测量装置（105）的光源（110）。 测量装置（105）包括流体（103）的至少一部分并被构造成被发射的光照亮。 该系统包括第二光传输装置（107b），其被配置为当测量装置（105）被照射到图像捕获装置时，从流体（103）传输阴影或反射的光。 图像捕获装置（113）被配置为基于所传送的关于流体的信息（103）来捕获测量装置（105）中的流体（103）的图像。 所述光源（110）和所述一个或多个图像捕获装置（113）从所述至少一个测量装置（105）远程布置。

公开(公告)号：US20150034807A1

公开(公告)日：2015-02-05

申请号：US14444218

申请日：2014-07-28

Applicant: Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG

Inventor： Andreas Lobbert ,  Ronny Michael ,  Christian Fanselow

IPC: G01N21/64 ,  G01J1/04 ,  G01J1/44

CPC classification number: G01N21/645 ,  G01J1/0425 ,  G01J1/44 ,  G01N21/77 ,  G01N21/78 ,  G01N21/783 ,  G01N21/80 ,  G01N2021/6432 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An arrangement for optical measurement of at least one process variable in a medium, comprising: at least one light source; at least one light receiver; an optical sensor element at least one data processing unit; and a light conductor. The light conductor connects the light source with the optical sensor element and the optical sensor element with the light receiver. The light conductor is embodied with at least three arms, wherein the first arm is arranged at the light source, the second arm is arranged at the light receiver and the third arm is arranged at the optical sensor element first arm and the second arm combine to form the third arm. The invention relates further to a measuring device comprising an above described arrangement.

Abstract translation: 一种用于光学测量介质中的至少一个过程变量的装置，包括：至少一个光源; 至少一个光接收器; 光学传感器元件至少一个数据处理单元; 和光导体。 光导体将光源与光学传感器元件和光学传感器元件与光接收器连接。 光导体具有至少三个臂，其中第一臂布置在光源处，第二臂布置在光接收器处，并且第三臂布置在光学传感器元件第一臂处，并且第二臂组合到 形成第三臂。 本发明进一步涉及包括上述布置的测量装置。

公开(公告)号：US20150015888A1

公开(公告)日：2015-01-15

申请号：US13941389

申请日：2013-07-12

Applicant: Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

Inventor： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC: G01N21/47

CPC classification number: G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

Abstract: An analyzer apparatus and method of use thereof is described to dynamically irradiate a sample with incident light where the incident light is varied in time in terms of any of: position, radial position relative to a point of the skin of a subject, solid angle, incident angle, depth of focus, energy, and/or intensity. For example, the incident light is varied in radial position as a function of time relative to one or more of a sample site, a point on skin of the subject, a detection optic, and/or a sample volume observed by a detection system. The radially varied incident light is used to enhance and/or vary light probing the epidermis, the dermis, and/or the subcutaneous fat of the subject or of a group of subjects.

Abstract translation: 描述了一种分析装置及其使用方法，用入射光动态地照射入射光，其中入射光随时间变化，即：相对于被摄体的皮肤的立体角度的位置，径向位置， 入射角，焦深，能量和/或强度。 例如，相对于样本部位，受试者的皮肤上的点，检测光学部件和/或由检测系统观察到的样品体积，入射光在径向位置上作为时间的函数而变化。 径向变化的入射光用于增强和/或变化探测受试者或一组受试者的表皮，真皮和/或皮下脂肪的光。

公开(公告)号：US08836945B1

公开(公告)日：2014-09-16

申请号：US14135691

申请日：2013-12-20

Applicant: U.S. Department of Energy

Inventor： Paul R. Ohodnicki, Jr. ,  Congjun Wang ,  Mark A. Andio

IPC: G01N21/00 ,  G01N21/55 ,  G01N21/78

CPC classification number: G01N21/783 ,  G01N2201/0826

Abstract: The disclosure relates to a method of detecting a change in a chemical composition by contacting a conducting oxide material with a monitored stream, illuminating the conducting oxide material with incident light, collecting exiting light, monitoring an optical signal based on a comparison of the incident light and the exiting light, and detecting a shift in the optical signal. The conducting metal oxide has a carrier concentration of at least 1017/cm3, a bandgap of at least 2 eV, and an electronic conductivity of at least 10−1 S/cm, where parameters are specified at the gas stream temperature. The optical response of the conducting oxide materials is proposed to result from the high carrier concentration and electronic conductivity of the conducting metal oxide, and the resulting impact of changing gas atmospheres on that relatively high carrier concentration and electronic conductivity. These changes in effective carrier densities and electronic conductivity of conducting metal oxide films and nanoparticles are postulated to be responsible for the change in measured optical absorption associated with free carriers. Exemplary conducting metal oxides include but are not limited to Al-doped ZnO, Sn-doped In2O3, Nb-doped TiO2, and F-doped SnO2.

Abstract translation: 本公开涉及一种通过使导电氧化物材料与监测的流体接触来检测化学组成的变化的方法，用入射光照射导电氧化物材料，收集离开的光，基于入射光的比较监测光信号 和出射光，并检测光信号的偏移。 导电金属氧化物的载流子浓度至少为1017 / cm3，带隙为至少2eV，电子传导率为至少10-1S / cm，其中在气流温度下规定了参数。 提出导电氧化物材料的光学响应是由导电金属氧化物的高载流子浓度和电子导电性引起的，并且由此产生的气体气氛变化对载流子浓度和电导率的影响。 假设导电金属氧化物膜和纳米颗粒的有效载流子密度和电子导电性的这些变化是造成与游离载体相关的测量的光吸收的变化的原因。 示例性的导电金属氧化物包括但不限于Al掺杂的ZnO，掺杂Sn的In 2 O 3，掺杂Nb的TiO 2和掺杂F的SnO 2。