公开(公告)号：US20060072632A1

公开(公告)日：2006-04-06

申请号：US10953043

申请日：2004-09-29

Applicant: Dale Flanders ,  Walid Atia ,  Mark Kuznetsov

Inventor： Dale Flanders ,  Walid Atia ,  Mark Kuznetsov

IPC: H01S3/10 ,  H01S3/08

CPC classification number: H01S5/141 ,  G01J1/4257 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/26 ,  G01J3/433 ,  G01J2003/2866 ,  G01N21/39 ,  G01N2021/399 ,  H01S3/08013 ,  H01S3/083 ,  H01S5/02252

Abstract: An optical power control system for a semiconductor source spectroscopy system controls power fluctuations in the tunable signal from the spectroscopy system and thus improves the noise performance of the system. This general solution has advantages relative to other systems that simply detect reference power levels during the scan and then correct the detected signal after interaction with the sample by reducing the requirements for coordinating the operation of the sample detectors and power or reference detectors. The spectroscopy system comprises a semiconductor source and a tunable filter. The combination of the semiconductor source and tunable signal illuminate a sample with a tunable signal, being tunable over a scan band. The power control system comprises an amplitude detector system for detecting the power of the tunable optical signal and power control system for regulating the amplitude of the tunable optical signal in response to its detected power.

Abstract translation: 用于半导体源光谱系统的光功率控制系统控制来自光谱系统的可调谐信号中的功率波动，从而改善系统的噪声性能。 该通用解决方案相对于在扫描期间简单地检测参考功率电平然后在与样品相互作用之后校正检测到的信号的其它系统具有优点，通过减少协调样品检测器和功率或参考检测器的操作的要求。 光谱系统包括半导体源和可调谐滤波器。 半导体源和可调信号的组合用可调信号照射样品，可在扫描带上调谐。 功率控制系统包括用于检测可调谐光信号的功率的振幅检测器系统和用于响应于其检测到的功率来调节可调谐光信号的幅度的功率控制系统。

公开(公告)号：US20060017923A1

公开(公告)日：2006-01-26

申请号：US11188064

申请日：2005-07-22

Applicant: Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

Inventor： Timothy Ruchti ,  Alexander Lorenz ,  Kevin Hazen

IPC: G01J3/28

CPC classification number: G01N21/274 ,  G01J3/28 ,  G01J3/433 ,  G01N21/359 ,  G01N2201/129 ,  G01N2201/1293

Abstract: The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.

Abstract translation: 本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。 更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。 随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

公开(公告)号：US20050201661A1

公开(公告)日：2005-09-15

申请号：US11079478

申请日：2005-03-15

Applicant: Hans-Peter Loock ,  Zhaoguo Tong

Inventor： Hans-Peter Loock ,  Zhaoguo Tong

IPC: G02B6/00

CPC classification number: G01J3/433 ,  G01J3/0218 ,  G01J9/00 ,  G01N21/7703 ,  G01N2021/7779

Abstract: The invention provides a method and apparatus for measuring one or more optical properties, such as absorbance and refractive index, of a test medium such as a gas, a liquid, or solid material. The method comprises providing a passive optical waveguide loop comprising the test medium, launching in the optical loop an intensity-modulated light at a reference phase, detecting a phase of said light along the optical waveguide loop, and comparing the detected phase of said light along the loop with the reference phase, wherein the comparison provides information about one or more optical properties of the test medium.

Abstract translation: 本发明提供了一种用于测量诸如气体，液体或固体材料的测试介质的一种或多种光学性质（例如吸光度和折射率）的方法和装置。 该方法包括提供包括测试介质的无源光波导环路，在光环路中发射参考相位的强度调制光，检测沿着光波导环路的所述光的相位，并将所检测到的相位沿着 具有参考相位的循环，其中比较提供关于测试介质的一个或多个光学特性的信息。

公开(公告)号：US20050185179A1

公开(公告)日：2005-08-25

申请号：US11064956

申请日：2005-02-25

Applicant: Sean Wang

Inventor： Sean Wang

IPC: G01J3/10 ,  G01J3/28 ,  G01J3/433 ,  G01J3/453

CPC classification number: G01J3/10 ,  G01J3/021 ,  G01J3/433 ,  G01J3/453

Abstract: A Fourier Transform (FT) spectrometer apparatus uses multi-element MEMS (Micro-Electro-Mechanical-Systems) or D-MEMS (Diffractive Micro-Electro-Mechanical-Systems) devices. A polychromatic light source is first diffracted or refracted by a dispersive component such as a grating or prism. The dispersed beam is intersected by a multi-element MEMS apparatus. The MEMS apparatus encodes each spectral component thereof with different time varying modulation through corresponding MEMS element. The light radiation is then spectrally recombined as a single beam. The beam is further split into to a reference beam and a probe beam. The probe light is directed to a sample and then the transmitted or reflected light is collected. Both the reference beam and probe beam are detected by a photo-detector. The detected time varying signal is analyzed by Fourier transformation to resolve the spectral components of the sample under measurement.

Abstract translation: 傅立叶变换（FT）光谱仪装置使用多元件MEMS（微机电系统）或D-MEMS（衍射微机电系统）装置。 多色光源首先被诸如光栅或棱镜之类的色散成分衍射或折射。 分散的光束由多元件MEMS装置相交。 MEMS装置通过相应的MEMS元件对其每个频谱分量进行不同的时变调制。 然后将光辐射作为单个光束进行光谱重组。 光束进一步分成参考光束和探测光束。 探针光被引导到样品，然后收集透射或反射的光。 参考光束和探测光束均由光电检测器检测。 通过傅里叶变换分析检测到的时变信号，以解析测量样品的光谱分量。

公开(公告)号：US06897952B1

公开(公告)日：2005-05-24

申请号：US09869371

申请日：1999-06-25

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/12 ,  G01J3/28 ,  G01J3/32 ,  G01J3/433 ,  G01J3/04

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/12 ,  G01J3/18 ,  G01J3/32 ,  G01J3/433 ,  G01J2001/4242 ,  G01J2003/2866

Abstract: A disc serving as a spatial radiation modulator has dispersed radiation filters thereon. Each filter has a transmittance or reflectance modulation function of the form sin2(mθ+pπ/4), where m is a positive integer and p has one of the four values 0, 1, 2, 3. A radiation beam including selected wavelength components is diffracted into an elongated image dispersed according to wavelength. Different wavelength components are focused onto different filters on the modulator and are encoded by corresponding filters. Since the modulation functions of the filters are orthogonal to one another, it is possible to extract the amplitude of each wavelength component after it has been encoded or modulated by corresponding filter from the total detected signal during one measurement.

Abstract translation: 用作空间辐射调制器的盘在其上具有分散的辐射滤波器。 每个滤光器具有形式为sinθ2（mta + ppi / 4）的透射率或反射调制函数，其中m是正整数，p具有四个值0,1,2,3中的一个 包括所选择的波长分量的辐射束被衍射成根据波长分散的细长图像。 不同的波长分量聚焦在调制器上的不同滤波器上，并由相应的滤波器编码。 由于滤波器的调制功能彼此正交，因此可以在一次测量期间从总检测信号对相应的滤波器进行编码或调制之后提取每个波长分量的振幅。

公开(公告)号：US06859275B2

公开(公告)日：2005-02-22

申请号：US09798860

申请日：2001-03-01

Applicant: William G. Fateley ,  Ronald R. Coifman ,  Frank Geshwind ,  Richard A. DeVerse

Inventor： William G. Fateley ,  Ronald R. Coifman ,  Frank Geshwind ,  Richard A. DeVerse

IPC: G01J3/02 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/28 ,  G01J3/32 ,  G01J3/457 ,  G01N21/39 ,  G02B26/08 ,  G02B27/10 ,  G01J3/04

CPC classification number: G02B27/1013 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/2889 ,  G01J3/32 ,  G01J3/42 ,  G01J3/433 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/39 ,  G01N2021/393 ,  G01N2021/6463 ,  G02B26/0833 ,  G02B26/0841 ,  G02B27/1086 ,  G02B27/126

Abstract: Encoded spatio-spectral information processing is performed using a system having a radiation source, wavelength dispersion device and two-dimensional switching array, such as digital micro-mirror array (DMA). In one aspect, spectral components from a sample are dispersed in space and modulated separately by the switching array, each element of which may operate according to a predetermined encoding pattern. The encoded spectral components can then be detected and analyzed. In a different aspect, the switching array can be used to provide a controllable radiation source for illuminating a sample with radiation patterns that have predetermined characteristics and separately encoded components. Various applications are disclosed.

Abstract translation: 使用具有辐射源，波长色散器件和二维开关阵列（例如数字微镜阵列（DMA））的系统执行编码空间光谱信息处理。 在一个方面，来自样本的频谱分量被分散在空间中，并且由开关阵列分开调制，开关阵列的每个元件可以根据预定的编码模式进行操作。 然后可以检测和分析编码的光谱分量。 在不同的方面，开关阵列可以用于提供用于利用具有预定特征的辐射图案和分开编码的部件来照射样本的可控辐射源。 公开了各种应用。

公开(公告)号：US20040007665A1

公开(公告)日：2004-01-15

申请号：US10453717

申请日：2003-06-03

Applicant: Baker Hughes Incorporated

Inventor： Rocco DiFoggio ,  Arnold Walkow ,  Paul Bergren

IPC: G01N021/64 ,  G01V005/08

CPC classification number: G01J3/26 ,  E21B49/08 ,  E21B2049/085 ,  G01J3/0202 ,  G01J3/0262 ,  G01J3/06 ,  G01J3/433 ,  G01J3/4406 ,  G01N21/0317 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/64 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2021/855

Abstract: The invention comprises an apparatus and method for simple fluorescence spectrometry in a down hole environment. The apparatus and method utilization of two UV light bulbs and an optically clear UV coupler and a fluid containment system. The optically clear UV coupler and fluid containment system are made of sapphire. The apparatus is attached in a manner that enables light transmitted from a light source on the far side of the fluid containment system to pass through a pathway in a plate holding the UV bulbs. UV light illuminates the fluid, which in turn fluoresces light. The fluoresced light is transmitted back towards the UV bulb mount and through the pathway towards an optical spectrum analyzer.

Abstract translation: 本发明包括在井下环境中简单荧光光谱法的装置和方法。 两种紫外灯泡和光学透明UV耦合器和流体容纳系统的装置和方法利用。 光学透明的UV耦合器和流体容纳系统由蓝宝石制成。 该装置以使得能够从流体容纳系统的远侧上的光源透射的光通过保持UV灯泡的板中的路径的方式附接。 紫外线照射流体，这又使荧光发光。 荧光的光被传输回到UV灯座并通过光谱分析仪。

公开(公告)号：US20030205682A1

公开(公告)日：2003-11-06

申请号：US10429426

申请日：2003-05-05

Inventor： Rakesh Kapoor ,  Martin Casstevens

IPC: G01J001/58

CPC classification number: G01J3/433 ,  G01J3/4406 ,  G01N21/6408

Abstract: A method of analyzing sample material having more than one fluorescing species comprises the steps of providing a plurality of intensity-modulated excitation light beams each being modulated at a respective unique frequency; directing the intensity-modulated excitation light beams to interact with the sample material; detecting fluorescence emission light from the sample material to provide signal information representative of detected light intensity versus time; and extracting a plurality of component emission signals from the signal information, wherein each component emission signal corresponds to a respective one of the modulated excitation light beams. Apparatus for implementing the method include flow cytometers and bulk sample analytical optical systems. The invention is helpful in determining species concentrations in cases where the fluorescing species have overlapping or substantially the same emission spectra.

Abstract translation: 分析具有多于一种荧光物质的样品材料的方法包括以下步骤：提供多个强度调制的激发光束，每个激发光束以相应的唯一频率被调制; 引导强度调制的激发光束与样品材料相互作用; 检测来自样品材料的荧光发射光，以提供表示检测到的光强度对时间的信号信息; 以及从所述信号信息提取多个分量发射信号，其中每个分量发射信号对应于调制的激发光束中的相应一个。 用于实施该方法的装置包括流式细胞仪和散装样品分析光学系统。 在荧光物质具有重叠或基本上相同的发射光谱的情况下，本发明有助于确定物质浓度。

公开(公告)号：US06549861B1

公开(公告)日：2003-04-15

申请号：US09636041

申请日：2000-08-10

Applicant: Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

Inventor： Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

IPC: G01R2316

CPC classification number: G01J3/28 ,  G01J3/0264 ,  G01J3/433 ,  G01J2003/2866

Abstract: An automated method for modeling spectral data is provided, wherein the spectral data generated by one of diffuse reflectance, clear transmission, or diffuse transmission. The method includes accessing a set of spectral data, the set of spectral data including, corresponding spectral data for each of a plurality of samples, the spectral data for each of the plurality of samples having associated therewith at least one constituent value, the at least one constituent value being a reference value for a target substance in the sample which is measured by a independent measurement technique. A plurality of data transforms are applied to the set of spectral data to generate, for each sample, a set of transformed and untransformed spectral data. The set of transformed and untransformed spectral data, with its associated constituent values, is divided into a calibration sub-set and a validation sub-set, and one or more of a partial least squares, a principal component regression, a neural net, or a multiple linear regression analysis is applied to the transformed and untransformed calibration data sub-sets to obtain corresponding modeling equations for predicting the amount of the target substance in a sample. The modeling equation which provides the best correlation between the spectral data in the validation sub-set and the corresponding constituent values in the validation sub-set is identified, preferably as a function of the SEE and SEP.

Abstract translation: 提供了一种用于建模光谱数据的自动化方法，其中由漫反射，透明或漫射传输之一产生的光谱数据。 该方法包括访问一组光谱数据，该光谱数据集合包括多个样本中的每一个的对应光谱数据，多个样本中的每一个的光谱数据与其相关联，至少一个成分值，至少 一个成分值是通过独立测量技术测量的样品中的目标物质的参考值。 将多个数据变换应用于该光谱数据集合，以针对每个样本生成一组经变换和未转换的光谱数据。 具有其相关联的成分值的经转换和未转换的光谱数据的集合被分成校准子集和确认子集，以及一个或多个偏最小二乘法，主成分回归，神经网络或 将多元线性回归分析应用于转化和未转换的校准数据子集，以获得用于预测样品中目标物质的量的相应建模方程。 确定在验证子集中的光谱数据与验证子集中的相应组成值之间提供最佳相关性的建模方程，优选地作为SEE和SEP的函数。

公开(公告)号：US20030048449A1

公开(公告)日：2003-03-13

申请号：US10147009

申请日：2002-05-16

Inventor： Peter G. Vander Jagt ,  Steven H. Peterson

IPC: G01N021/59

CPC classification number: G01N21/255 ,  G01J3/10 ,  G01J3/433 ,  G01J3/50 ,  G01J3/501 ,  G01J3/524 ,  G01J2001/4242 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0691

Abstract: An instrument and method for measuring light or color using modulated illumination. The system includes an LED illuminator modulated at a specific frequency for illuminating the sample, and a sensor capable of differentiating between the modulated light from the sample and unmodulated ambient light. The instrument is therefore capable of nullseeingnull only light from the sample, while ignoring ambient light. In a second embodiment, the system includes multiple illuminators of different colors each modulated at a unique frequency so that the sample can be measured at multiple at each of the different frequencies.

Abstract translation: 一种使用调制照明测量光或颜色的仪器和方法。 该系统包括以特定频率调制以照亮样品的LED照明器，以及能够区分来自样品的调制光和未调制的环境光的传感器。 因此，仪器只能“看到”来自样品的光，同时忽略环境光。 在第二实施例中，系统包括多个不同颜色的照明器，每个照明器以独特的频率进行调制，使得可以在不同频率的每一个处以多个测量样本。