公开(公告)号：WO2005030676A1

公开(公告)日：2005-04-07

申请号：PCT/GB2004/004153

申请日：2004-09-27

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN ,  SCHWEIGER, Lutz, F. ,  CRAIB, Stuart, A. ,  WELCH, Andrew, E. ,  SHARP, Peter, F.

Inventor： SCHWEIGER, Lutz, F. ,  CRAIB, Stuart, A. ,  WELCH, Andrew, E. ,  SHARP, Peter, F.

IPC: C07B59/00

CPC classification number: C07B59/00 ,  C07D279/20

Abstract: This invention pertains to methods of [ 11 C]-radiolabelling "phenothiazine" and "phenothiazine-like" compounds, which have a pendant group (which is a primary amino group; a cationic primary imino group; a secondary amino group; a cationic secondary imino group; a primary imino group; or a secondary imino group), by reaction with [ 11 C]methyl trifluoromethanesulfonate (CF 3 SO 2 O 11 CH 3 ), also known as [ 11 C]methyl triflate. This reaction converts the pendant group into a [ 11 C]methyl-labelled pendant group. The resulting [ 11 C]-radiolabelling product is useful, for example, as an in vivo positron emission tomography (PET) tracer, for example, for patients suffering from melanoma, the most serious form of skin cancer, and tauopathy (e.g., Alzheimer's disease). The present invention also pertains to the resulting [ 11 C]-radiolabelling products, compositions comprising them, their use in methods of (e.g., PET) imaging, their use in methods of medical treatment and diagnosis, etc.

Abstract translation: 本发明涉及[11 C] - 放射性标记“吩噻嗪”和“吩噻嗪样”化合物的方法，其具有侧基（其为伯氨基;阳离子性原亚氨基;仲氨基; 通过与[C 13 C]三氟甲磺酸甲酯（CF 3 SO 2 O 11 CH 3）反应，也称为[11 C]三氟甲磺酸甲酯，通过与二亚氨基反应而获得。 该反应将侧基转化为[11 C]甲基标记的侧基。 所得的[11 C] - 放射性标记产物可用于例如体内正电子发射断层扫描（PET）示踪剂，例如对于患有黑素瘤的患者，最严重的皮肤癌形式和tau蛋白病（例如， ， 阿尔茨海默氏病）。 本发明还涉及所得的[11 C] - 放射性标记物，包含它们的组合物，它们在（例如PET）成像方法中的用途，它们在医学治疗和诊断方法中的应用等。

公开(公告)号：WO2005028707A2

公开(公告)日：2005-03-31

申请号：PCT/US2004012147

申请日：2004-04-20

Applicant: UNIV JOHNS HOPKINS ,  SRINIVASAN RENGASWAMY ,  SAFFARIAN HASSANN M ,  FOGEL STUART A ,  CROOKSTON JAMES C

Inventor： SRINIVASAN RENGASWAMY ,  SAFFARIAN HASSANN M ,  FOGEL STUART A ,  CROOKSTON JAMES C

IPC: C23F11/18

CPC classification number: C23F11/18

Abstract: Methods for inhibiting the microbiologically influenced corrosion of a metal are provided comprising treating the surface of the metal with a microbiologically influenced corrosion inhibiting effective amount of a source of rare earth metal ions; wherein the surface of the metal is in the presence of corrosive reagents such as chloride ions and acids and one or more microorganisms capable of colonizing on and/or embedding into the surface and preventing self-healing of the surface of the metal damaged by the corrosive reagents.

Abstract translation: 提供了抑制微生物影响金属腐蚀的方法，包括用微生物影响腐蚀抑制有效量的稀土金属离子源处理金属表面; 其中所述金属的表面存在腐蚀性试剂如氯离子和酸以及一种或多种能够在所述表面上定居和/或嵌入所述表面并防止由所述腐蚀剂损坏的所述金属的表面的自修复的一种或多种微生物 试剂。

公开(公告)号：WO2004016749A2

公开(公告)日：2004-02-26

申请号：PCT/US2003/025389

申请日：2003-08-14

Applicant: PHARMACIA CORPORATION ,  ROSS, Stuart, A.

Inventor： ROSS, Stuart, A.

IPC: C12N

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y602/01003 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

Abstract: Antisense compounds, compositions, and methods are provided for modulating the expression of acyl-Coa synthesis 1, heretofore referred to as ACS1. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding ACS1. Methods of using these compounds for modulation of ACS1 expression and for treatment of diseases associated with expression of ACS1 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节酰基-CoA合成1（迄今称为ACS1）的表达。 该组合物包含靶向编码ACS1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节ACS1表达和治疗与ACS1表达相关的疾病的方法。

公开(公告)号：WO0063421A9

公开(公告)日：2002-06-06

申请号：PCT/US0010484

申请日：2000-04-19

Applicant: BIOS GROUP LP ,  KAUFFMAN STUART A ,  LEVITAN BENNETT S

Inventor： KAUFFMAN STUART A ,  LEVITAN BENNETT S

IPC: C07B61/00 ,  C40B30/02 ,  G01N33/68 ,  G06F19/00 ,  G06F19/16 ,  G06F19/24 ,  C12Q1/00 ,  C07H21/02 ,  C12P19/24 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50

CPC classification number: G06F19/16 ,  C40B30/02 ,  C40B50/02 ,  G01N33/6803 ,  G01N2500/00 ,  G06F19/24 ,  G06F19/704

Abstract: The present invention is directed to production of a molecule having a predetermined property. In accordance with one embodiment, a library of initial candidate molecules that are at least somewhat dissimilar to a chosen target molecule or "targetshape" is generated. Variants of the initial candidates are generated and screened to identify intermediate candidates from among those variants that are either more or less similar to the targetshape. Data mining techniques such as neural networks are used to extract information about the molecule structures and shapes which lead to the desired activity. Molecular data bases may be screened for candidates matching the preferred shape description or molecules matching the preferred shape description may be synthesized. The process may be iterated by generating variants of the intermediate candidates and screening these variants to identify molecules futher more or less similar to the targetshape.

Abstract translation: 本发明涉及具有预定特性的分子的制备。 根据一个实施方案，产生至少在某种程度上不同于所选择的靶分子或“靶标形状”的初始候选分子的文库。 生成和筛选初始候选人的变体，以从与目标形状大致相似的那些变体中识别中间候选。 使用诸如神经网络的数据挖掘技术来提取关于导致所需活动的分子结构和形状的信息。 可以筛选与优选形状描述匹配的候选物的分子数据库，或者可以合成优选形状描述匹配的分子。 可以通过产生中间候选物的变体并筛选这些变体来鉴定或多或少与靶标相似的分子来迭代该过程。

公开(公告)号：WO9743901A9

公开(公告)日：2001-06-21

申请号：PCT/US9708558

申请日：1997-05-20

Applicant: UNIV VANDERBILT ,  MILLER GERALDINE G ,  PEEK RICHARD M JR ,  THOMPSON STUART A ,  BLASER MARTIN J

Inventor： MILLER GERALDINE G ,  PEEK RICHARD M JR ,  THOMPSON STUART A ,  BLASER MARTIN J

IPC: G01N33/53 ,  A61K31/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/106 ,  A61K39/395 ,  A61P31/00 ,  A61P31/04 ,  C07K14/205 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/68 ,  C12R1/01 ,  G01N33/569 ,  A01N43/04 ,  A61K31/70 ,  A61K39/38 ,  C07K1/00 ,  C12P21/06

CPC classification number: C07K14/205 ,  A61K38/00 ,  A61K39/00

Abstract: A purified IceA protein of Helicobacter pylori is provided. The protein is expressed as either an IceA 1 or an IceA 2 variant. A purified polypeptide fragment of the IceA protein is also provided. An antigenic fragment of IceA is provided. An isolated nucleic acid that encodes an IceA protein of H. pylori is provided. A nucleic acid that encodes an IceA 1 variant and a nucleic acid that encodes an IceA 2 variant is also provided. Fragments of the IceA gene are provided. A method of detecting the presence of an antibody against H. pylori in a sample is provided. The method comprises the following steps: a) contacting the sample with a purified IceA protein of H. pylori or a H. pylori-specific fragment thereof; and b) detecting the binding of the antibody in the sample to the protein or fragment, the detection of biding indicating the presence in the sample of antibodies against H. pylori. A method of detecting the presence of an antibody against an ulcerative Helicobacter pylori strain in a sample is also provided.

Abstract translation: 提供幽门螺杆菌纯化的IceA蛋白。 蛋白质表达为IceA 1或IceA 2变体。 还提供了IceA蛋白的纯化多肽片段。 提供了IceA的抗原片段。 提供编码幽门螺杆菌的IceA蛋白的分离的核酸。 还提供了编码IceA 1变体的核酸和编码IceA 2变体的核酸。 提供了IceA基因的片段。 提供了检测样品中幽门螺杆菌抗体的存在的方法。 该方法包括以下步骤：a）将样品与幽门螺杆菌的纯化IceA蛋白或幽门螺杆菌特异性片段接触; 和b）检测样品中的抗体与蛋白质或片段的结合，检测指示在幽门螺杆菌抗体样品中的存在。 还提供了检测样品中针对溃疡性幽门螺杆菌菌株的抗体存在的方法。

公开(公告)号：WO1994024314A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004314

申请日：1994-04-19

Applicant: KAUFFMAN, Stuart, A. ,  REBEK, Julius, Jr.

IPC: C12Q01/68

CPC classification number: C12N15/1093 ,  C07K1/047 ,  C12N9/0002 ,  C12P1/00 ,  C12P19/34 ,  C12Q1/6811 ,  C40B40/10 ,  C40B50/06

Abstract: Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical composition of a compound having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by "random" chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.

Abstract translation: 公开了生成新化合物的方法。 本发明不需要预先知道具有所需性质的化合物的结构或化学组成。 本发明的公开内容提供了通过“随机”化学可以产生未知化合物的多样性，并且可以筛选出这些多种未知化合物的一种或多种所需性质以检测合适化合物的存在。 在一个方面，使有机化合物的起始基团经历一系列化学反应，以产生多种新的有机化合物，其筛选出具有所需性质的有机化合物的存在。 在本发明的另一方面，由代表多种催化活性的一组酶的底物组产生多种化合物。

公开(公告)号：WO1988005001A1

公开(公告)日：1988-07-14

申请号：PCT/US1987003474

申请日：1987-12-23

Applicant: LARSEN, Stuart, A. ,  CHRISTENSEN, Charles, S., Jr.

IPC: B60P03/07

CPC classification number: B65D88/546 ,  B60P3/08 ,  B65D88/121 ,  B65D2585/6867 ,  B65G2201/0294

Abstract: Method and apparatus to enhance intermodal containers (10) for transport of vehicles wherein multiple longitudinal rails (14) on container walls support movable and removable transverse cargo pallets (16) having foot members (18) which are articulatably connected to the pallets. Cargo, preferably an automobile fixed to front and rear pallets, is loaded by inserting each pallet's feet onto appropriate rail(s) at door opening, then sliding to stowage spot, the rail selection determining height and tilt. Stowage of any mix of automobiles in intermodal containers is optimized by double-decking, half-decking, double half-decking, mirror-imaging, and envelope intervention. On back haul, pallets serve other cargo as restraints, hangers, pallets, or dunnage deck supports, or they are stowed out of the way. Method and apparatus permit automated load planning and container stuffing and make containerized shipment of large volumes of automobiles cost competitive with current methods.

公开(公告)号：US20230346713A1

公开(公告)日：2023-11-02

申请号：US18061081

申请日：2022-12-02

Applicant: Stuart A. LIPTON

Inventor： Stuart A. LIPTON

IPC: A61K31/04 ,  C12Q1/6883

CPC classification number: A61K31/04 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61P25/00

Abstract: Disclosed herein are methods for treating juvenile onset neurological conditions, such as autism (ASD), intellectual disability, or epilepsy, with an inhibitor of N-methyl-D-aspartate receptor (NMDAR). The inhibitor may be NitroSynapsin or a derivative thereof.

公开(公告)号：US09798712B2

公开(公告)日：2017-10-24

申请号：US13609541

申请日：2012-09-11

Applicant: Beilei Xu ,  Stuart A. Schweid ,  Raja Bala ,  Rinku Gajera

Inventor： Beilei Xu ,  Stuart A. Schweid ,  Raja Bala ,  Rinku Gajera

IPC: G06F5/16 ,  G06F17/24 ,  G06F17/28

CPC classification number: G06F17/248 ,  G06F17/289

Abstract: The present disclosure provides a method of producing a personalized medical record, comprising: sensing capabilities of a receiving device; retrieving stock information; retrieving personalized information; combining at least a portion of the stock information and at least a portion of the personalized information into the personalized record; formatting the personalized record based on a combination of the capabilities of the receiving device and a user's preference; and, transmitting the formatted personalized record to the device.

公开(公告)号：US09511165B2

公开(公告)日：2016-12-06

申请号：US13280340

申请日：2011-10-24

Applicant: Florin-Joseph Vlad ,  Stuart A. Zlotnik ,  Natalie Hinden-Kuhles

Inventor： Florin-Joseph Vlad ,  Stuart A. Zlotnik ,  Natalie Hinden-Kuhles

IPC: A61L9/04 ,  A61L9/01 ,  A61L9/14

CPC classification number: A61L9/01 ,  A61L9/14

Abstract: Air freshener compositions, devices, and methods are disclosed.

Abstract translation: 公开了空气清新剂组合物，装置和方法。