公开(公告)号：US07245374B2

公开(公告)日：2007-07-17

申请号：US10539193

申请日：2003-11-21

Applicant: Robert Frans Maria Hendriks

Inventor： Robert Frans Maria Hendriks

IPC: H01J40/14

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

Abstract: An optical analysis system (1), which is arranged to determine amplitude of a principal component of an optical signal, includes a first detector (5) for detecting the optical signal weighted by a first spectral weighting function, and a second detector (6) for detecting the optical signal weighted by a second spectral weighting function. For an improved signal-to-noise ratio, the optical analysis system (1) further includes a dispersive element (2) for spectrally dispersing the optical signal, and a distribution element (4) for receiving the spectrally dispersed optical signal and for distributing a first part of the optical signal weighted by the first spectral weighting function to the first detector (5) and a second part of the optical signal weighted by the second spectral weighting function to the second detector (6). The optical analysis system (1) is suited for use in numerous applications including a spectroscopic analysis system (30) and a blood analysis system (40).

Abstract translation: 被配置为确定光信号的主成分的幅度的光学分析系统（1）包括用于检测由第一光谱加权函数加权的光信号的第一检测器（5）和第二检测器（6） 用于检测由第二频谱加权函数加权的光信号。 为了提高信噪比，光学分析系统（1）还包括用于光谱分散光信号的色散元件（2）和用于接收光谱分散光信号并用于分配光信号的分布元件（4） 由第一光谱加权函数加权到第一检测器（5）的光信号的第一部分和由第二光谱加权函数加权到第二检测器（6）的光信号的第二部分。 光学分析系统（1）适用于许多应用，包括光谱分析系统（30）和血液分析系统（40）。

公开(公告)号：US20070103669A1

公开(公告)日：2007-05-10

申请号：US11592329

申请日：2006-11-03

Applicant: Florent Picard ,  Clementina Lopez Garcia ,  Jean-Marc Bader ,  Francois Wahl

Inventor： Florent Picard ,  Clementina Lopez Garcia ,  Jean-Marc Bader ,  Francois Wahl

IPC: G01J3/00

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/3563 ,  G01N33/28 ,  G01N2201/129

Abstract: This invention describes a method for determining the content of conjugated diolefins by means of the measurement of the MAV of a sample of catalytic cracking gasoline or thermal cracking gasoline, from its NIR (near-infrared) spectrum, and the application of said method for monitoring a unit for selective hydrogenation of the cracking gasolines.

Abstract translation: 本发明描述了一种通过从其NIR（近红外）光谱测量催化裂化汽油或热裂解汽油样品的MAV以及所述监测方法的应用来测定共轭二烯烃含量的方法 一种用于裂解汽油的选择氢化的单元。

公开(公告)号：US20070027374A1

公开(公告)日：2007-02-01

申请号：US11543841

申请日：2006-10-06

Applicant: Nils Wihlborg

Inventor： Nils Wihlborg

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/359 ,  G01N2201/0627 ,  G01N2201/129

Abstract: An optical blood analyte monitor (2) comprises a near infra-red light source and a complementary detection (6) means; a component analyser (12) having access to a chemometric model linking optical spectral features to a level of blood analyte of interest and configured to apply the model to signals received from the detection (6) means and a tilting filter arrangement (8) having a plurality of optical interference filters (20a . . . e;56a . . . d), each filter being tiltable to vary a wavelength of incident light from the source transmitted there through. The light source comprises a plurality of light emitters (4a . . . e) each being arranged to emit light along a different associated light-path (16a . . . e) in which is located an associated different one of the plurality of the interference filters (20a . . . e) and towards a same analysing region (18) at which a tissue volume (finger for example) containing a blood sample to be analysed is located in use.

Abstract translation: 光学血液分析物监测器（2）包括近红外光源和互补检测（6）装置; 组件分析器（12），其访问化学计量模型，其将光谱特征与感兴趣的血液分析物的水平相关联并且被配置为将模型应用于从检测装置（6）装置接收的信号和倾斜滤波器装置（8） 多个光学干涉滤光器（20 a ... e; 56 a ... d），每个滤光片可倾斜以改变从其透射的源的入射光的波长。 光源包括多个发光体（4 ...，e），每个发光体被配置成沿着不同的相关光路（16a，...）发射光，其中位于多个 所述干涉滤光器（20μm）和朝向使用包含待分析血液样本的组织体积（例如手指）的相同分析区域（18）。

公开(公告)号：US20050154539A1

公开(公告)日：2005-07-14

申请号：US11076636

申请日：2005-03-10

Applicant: Matthew Butler ,  Grant Plummer

Inventor： Matthew Butler ,  Grant Plummer

IPC: G01J3/00 ,  G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01N21/00

CPC classification number: G01J3/453 ,  G01J3/0264 ,  G01J3/28 ,  G01N21/3518 ,  G01N2021/1793 ,  G01N2201/1211 ,  G01N2201/129

Abstract: A fourth embodiment of the present invention is a method of generating a temperature compensated absorbance spectrum. The method includes the steps of: a. providing a sample spectrum and an estimated temperature of a backdrop object; b. from a set of known temperature spectra related to a known background temperature, selecting at least two known temperature spectra representing a background temperature above and below the estimated temperature; c. comparing the sample spectrum to the known temperature spectra in order to determine a sample background spectrum; and d. calculating an absorbance spectrum from the sample spectrum and the background spectrum.

Abstract translation: 本发明的第四实施例是产生温度补偿吸收光谱的方法。 该方法包括以下步骤：a。 提供样本谱和背景物体的估计温度; b。 从与已知背景温度相关的一组已知温度谱中，选择表示背景温度高于和低于估计温度的至少两个已知温度光谱; C。 将样品光谱与已知的温度光谱进行比较，以确定样品背景光谱; 和d。 从样品光谱和背景光谱计算吸收光谱。

公开(公告)号：US06885965B2

公开(公告)日：2005-04-26

申请号：US10444045

申请日：2003-05-22

Applicant: Matthew Butler ,  Grant Plummer

Inventor： Matthew Butler ,  Grant Plummer

IPC: G01J3/00 ,  G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01B9/02 ,  G06F15/00 ,  G06F15/46

CPC classification number: G01J3/453 ,  G01J3/0264 ,  G01J3/28 ,  G01N21/3518 ,  G01N2021/1793 ,  G01N2201/1211 ,  G01N2201/129

Abstract: A fourth embodiment of the present invention is a method of generating a temperature compensated absorbance spectrum. The method includes the steps of: a. providing a sample spectrum and an estimated temperature of a backdrop object; b. from a set of known temperature spectra related to a known background temperature, selecting at least two known temperature spectra representing a background temperature above and below the estimated temperature; c. comparing the sample spectrum to the known temperature spectra in order to determine a sample background spectrum; and d. calculating an absorbance spectrum from the sample spectrum and the background spectrum.

公开(公告)号：US06847447B2

公开(公告)日：2005-01-25

申请号：US09804613

申请日：2001-03-12

Applicant: Richard M. Ozanich

Inventor： Richard M. Ozanich

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/35 ,  G01N33/02 ,  G01N21/25 ,  G01N21/47

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/28 ,  G01J3/36 ,  G01J3/42 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/025 ,  G01N2021/3155 ,  G01N2021/8466 ,  G01N2201/129 ,  Y10S250/91

Abstract: This disclosure is of 1) the utilization of the spectrum from 250 nm to 1150 nm for measurement of prediction of one or more parameters, e.g., brix, firmness, acidity, density, pH, color and external and internal defects and disorders including, for example, surface and subsurface braises, scarring, sun scald, punctures, in N—H, C—H and O—H samples including fruit; 2) an apparatus and method of detecting emitted light from samples exposed to the above spectrum in at least one spectrum range and, in the preferred embodiment, in at least two spectrum ranges of 250 to 499 nm and 500 nm; 3) the use of the chlorophyl band, peaking at 690 nm, in combination with the spectrum from 700 nm and above to predict one or more of the above parameters; 4) the use of the visible pigment region, including xanthophyll, from approximately 250 nm to 499 nm and anthocyanin from approximately 500 to 550 nm, in combination with the chlorophyl band and the spectrum from 700 nm and above to predict the all of the above parameters.

Abstract translation: 本公开是1）利用250nm至1150nm的光谱来测量一种或多种参数的预测，例如白利糖度，硬度，酸度，密度，pH，颜色以及外部和内部缺陷和紊乱，包括对于 例如，包括水果在内的NH，CH和OH样品中的表面和地下辫子，疤痕，太阳烫伤，穿刺， 2）一种在至少一个光谱范围内检测暴露于上述光谱的样品的发射光的装置和方法，在优选实施例中，在250至499nm和500nm的至少两个光谱范围内; 3）使用叶绿素带，峰值在690nm，与700nm以上的光谱结合，以预测上述一个或多个参数; 4）使用约250nm至499nm的可见颜料区域（包括叶黄素）和约500至550nm的花色素苷，与叶绿素谱带和700nm及以上的光谱结合使用，以预测上述全部 参数。

公开(公告)号：US20040034292A1

公开(公告)日：2004-02-19

申请号：US10638656

申请日：2003-08-11

Inventor： James Mansfield ,  Jenny Freeman

IPC: A61B005/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/441 ,  A61B5/445 ,  A61B5/7264 ,  G01J3/28 ,  G01N2201/129

Abstract: This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.

Abstract translation: 本发明涉及用于处理体内皮肤自动荧光光谱以测定血糖水平的方法。 本发明还涉及使用多变量分类或定量模型分类细胞或组织样品或定量细胞或组织的组分的方法。

公开(公告)号：US06675029B2

公开(公告)日：2004-01-06

申请号：US10183660

申请日：2002-06-25

Applicant: Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

Inventor： Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

IPC: A61B500

CPC classification number: A61B5/444 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7264 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/129

Abstract: An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.

Abstract translation: 用于非破坏性地估计活体受试者的组织性质（例如水合）的装置和方法利用通过用近红外（NIR）光照射皮肤组织进行的体内光谱测量。 该装置包括结合主体界面的光谱仪器。 所得到的光谱被传递到分析器以用于进一步处理，其包括检测和消除无效光谱测量以及预处理以增加信噪比。 最后，应用从示例性测量集合开发的估计模型来预测样品的组织水合。 组织水合测量的方法提供关于系统组织变异性的主要来源的附加信息，即皮肤表皮层的水含量和入射光的穿透深度。 因此，组织水合测量适用于生物和化学化合物（如分析物）的进一步光谱分析和定量。

公开(公告)号：US20030060693A1

公开(公告)日：2003-03-27

申请号：US10183660

申请日：2002-06-25

Inventor： Stephen L. Monfre ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Brian J. Wenzel

IPC: A61B005/00

CPC classification number: A61B5/444 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7264 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/129

Abstract: An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.

Abstract translation: 用于非破坏性地估计活体受试者的组织性质（例如水合）的装置和方法利用通过用近红外（NIR）光照射皮肤组织进行的体内光谱测量。 该装置包括结合主体界面的光谱仪器。 所得到的光谱被传递到分析器以用于进一步处理，其包括检测和消除无效光谱测量以及预处理以增加信噪比。 最后，应用从示例性测量集合开发的估计模型来预测样品的组织水合。 组织水合测量的方法提供关于系统组织变异性的主要来源的附加信息，即皮肤表皮层的水含量和入射光的穿透深度。 因此，组织水合测量适用于生物和化学化合物（如分析物）的进一步光谱分析和定量。

公开(公告)号：US06456955B1

公开(公告)日：2002-09-24

申请号：US09730126

申请日：2000-12-05

Applicant: Richard Wayne Andrews ,  Virginia L. Corbin

Inventor： Richard Wayne Andrews ,  Virginia L. Corbin

IPC: G01N3700

CPC classification number: G01N30/88 ,  G01N2030/8804 ,  G01N30/02 ,  G01N2201/129

Abstract: A method and apparatus for automating the qualification process for chromatographic systems. Automation technology and regression analysis are used for qualifying a chromatography system. The trained operator prepares the chromatography system to ensure that the samples, solvents, and the separation column are ready for analysis. The qualification of the detector, the solvent delivery system, the sample manager, the gradient proportioning system, the column heater, and the delay volume of the chromatography system are completed without the necessity of operator intervention. Regression analysis is performed to compute performance statistics that demonstrate the accuracy, linearity, and precision of the chromatographic system and quantify its suitability for chromatographic analysis.

Abstract translation: 用于自动化色谱系统鉴定过程的方法和设备。 自动化技术和回归分析用于对色谱系统进行鉴定。 经过培训的操作人员准备色谱系统，以确保样品，溶剂和分离柱准备好进行分析。 完成了检测器，溶剂输送系统，样品管理器，梯度配比系统，色谱柱加热器和色谱系统的延迟体积的鉴定，无需操作员干预。 进行回归分析以计算性能统计，显示色谱系统的准确度，线性和精度，并量化其色谱分析的适用性。