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公开(公告)号：CA2781433A1
公开(公告)日：2011-05-26
申请号：CA2781433
申请日：2010-11-19
Applicant: ACADEMIA SINICA
Inventor： LIANG SHU-MEI , CHIU CHING-FENG , HUNG SHAO-WEN , PENG JEI-MING , LIANG CHI-MING
Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.
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公开(公告)号：PL1697539T3
公开(公告)日：2010-12-31
申请号：PL04776718
申请日：2004-06-18
Applicant: ACADEMIA SINICA
Inventor： CHEN YUAN-TSONG , HUNG SHUEN-IU , CHUNG WEN-HUNG , WU JER-YUARN
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公开(公告)号：MY142178A
公开(公告)日：2010-10-15
申请号：MYPI20032638
申请日：2003-07-15
Applicant: ACADEMIA SINICA
Inventor： SHYUR LIE-FEN , YANG NING-SUN , KANG PEI-LING , SUN SHOW-JANE , WANG SHENG-YANG
Abstract: THE PRESENT INVENTION PROVIDES MEDICINALLY ACTIVE EXTRACTS AND FRACTIONS, AND A METHOD FOR PREPARING THE SAME BY EXTRACTING AND FRACTIONING CONSTITUENTS FROM THE TISSUE OF PLANT COMPONENTS OF THE ANOECTOCHILUS FAMILY. THESE ACTIVE EXTRACTS AND FRACTIONS ARE USEFUL FOR PREVENTING OR INHIBITING TUMOR GROWTH.
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公开(公告)号：DE602004028508D1
公开(公告)日：2010-09-16
申请号：DE602004028508
申请日：2004-06-18
Applicant: ACADEMIA SINICA
Inventor： CHEN YUAN-TSONG , HUNG SHUEN-IU , CHUNG WEN-HUNG , WU JER-YUARN
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公开(公告)号：PT1831402E
公开(公告)日：2010-09-10
申请号：PT05855433
申请日：2005-12-21
Applicant: ACADEMIA SINICA
Inventor： CHEN YUAN-TSONG , YUAN HSIANG-YU , CHEN JIN-JER
IPC: C12Q1/68
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Patent Agency Ranking
公开(公告)号：GB2460966B
公开(公告)日：2010-05-19
申请号：GB0913559
申请日：2008-05-30
Applicant: ACADEMIA SINICA
Inventor： HUANG CHUN-YUNG , LIANG SHU-MEI , LIANG CHI-MING
Abstract: A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC50 in the nanomolar range. A second-generation Man9 dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.
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公开(公告)号：GB2460965B
公开(公告)日：2010-05-19
申请号：GB0913558
申请日：2008-05-30
Applicant: ACADEMIA SINICA
Inventor： LIANG SHU-MEI , HUANG CHUN-YUNG
Abstract: A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC50 in the nanomolar range. A second-generation Man9 dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.
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公开(公告)号：GB2460283B
公开(公告)日：2010-04-21
申请号：GB0809919
申请日：2008-05-30
Applicant: ACADEMIA SINICA
Inventor： LIANG SHU-MEI , HUANG CHUN-YUNG , LIANG CHI-MING
Abstract: A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC50 in the nanomolar range. A second-generation Man9 dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.
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359.发明专利
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