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    SUBSTITUTED ALIPHATIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS
    361.
    发明申请
    SUBSTITUTED ALIPHATIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS 审中-公开
    取代的含有胺类的大肠杆菌免疫调节剂

    公开(公告)号：WO1994021253A1

    公开(公告)日：1994-09-29

    申请号：PCT/US1994002623

    申请日：1994-03-11

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KAWAI, Megumi ,  LULY, Jay, R.

    IPC: A61K31/395

    CPC classification number: C07D498/18

    Abstract: Compounds having formula (I) and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R and R is hydrogen, and the other of R and R is a radical having formula (II), as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.

    Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 104和R 105中的一个是氢，R 104和R 105中的另一个是基团 具有式（II）的化合物，以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。

    MULTIPURPOSE REAGENT SYSTEM FOR RAPID LYSIS OF WHOLE BLOOD SAMPLES
    362.
    发明申请
    MULTIPURPOSE REAGENT SYSTEM FOR RAPID LYSIS OF WHOLE BLOOD SAMPLES 审中-公开
    用于快速检测全血样品的多用途试剂系统

    公开(公告)号：WO1994018828A1

    公开(公告)日：1994-09-01

    申请号：PCT/US1994001306

    申请日：1994-02-03

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KIM, Young, Ran ,  KANTOR, Joanna

    IPC: A01N01/02

    CPC classification number: C12N1/06 ,  G01N15/1459 ,  G01N33/5094 ,  G01N33/56972 ,  G01N33/80 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  Y10S436/805 ,  Y10S436/808 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25

    Abstract: A multipurpose reagent system for rapid analysis of a whole blood sample allowing the determination of at least five classes of peripheral white blood cells, nucleated red blood cells, and lymphocyte immunophenotyping on automated hematology instrumentation. The multipurpose reagent system lyses red cells rapidly, while it concurrently fixes white cells and preserves surface antigens on lymphocytes. The multipurpose reagent system comprises from about 3 to 7 grams per liter of a non-quaternary ammonium salt, from about 0.04 to about 0.10 percent by volume of an aliphatic aldehyde with one to four carbons, from about 10 mM to about 20 mM of a non-phosphate buffer which is inert to the aliphatic aldehyde, and a sufficient amount of water to give a pH between 5.5 and 7.5 and an osmolality of between about 160 to about 310 mOsm per liter.

    Abstract translation: 用于快速分析全血样品的多用途试剂系统，允许在自动血液仪器上测定至少五类外周白细胞，有核红细胞和淋巴细胞免疫表型分析。 多用途试剂系统迅速溶解红细胞，同时固定白细胞并保留淋巴细胞上的表面抗原。 多用途试剂系统包含约3至7克/升非季铵盐，约0.04至约0.10体积％的具有一至四个碳的脂族醛，约10mM至约20mM的 对脂族醛是惰性的非磷酸盐缓冲剂，以及足够量的水以产生5.5至7.5之间的pH和约160至约310mOsm /升的渗透压。

    METHOD OF TESTING FOR LEAKAGE IN A SOLUTION PUMPING SYSTEM
    363.
    发明申请
    METHOD OF TESTING FOR LEAKAGE IN A SOLUTION PUMPING SYSTEM 审中-公开
    溶液泵送系统泄漏测试方法

    公开(公告)号：WO1994017307A1

    公开(公告)日：1994-08-04

    申请号：PCT/US1994001105

    申请日：1994-01-18

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  WYNKOOP, Richard, D.

    IPC: F04B51/00

    CPC classification number: A61M5/16854 ,  A61M2205/12 ,  A61M2205/70 ,  F04B43/04 ,  F04B51/00

    Abstract: A method of testing a pumping system (10) including a pump cassette (12) effects pressurization of the system, with subsequent monitoring of any pressure loss in the system. This is achieved by closing any inlets (24) and outlets (26) of the cassette, and thereafter overpressurizing the cassette beyond its normal operating range. Pressure measurements are taken before and after a specified time interval, with any significant pressure loss indicating system leakage. In the preferred practice, the diaphragm (22) of the pump cassette is first subjected to cold flow, or "creep", thereby minimizing the influence of cold flow of the diaphragm on subsequent pressure measurement.

    Abstract translation: 测试包括泵盒（12）的泵送系统（10）的方法对系统进行加压，随后监测系统中的任何压力损失。 这是通过关闭盒的任何入口（24）和出口（26）来实现的，然后使盒超过正常工作范围。 在指定的时间间隔之前和之后采取压力测量，任何明显的压力损失表示系统泄漏。 在优选的实施例中，泵盒的隔膜（22）首先经受冷流或“蠕变”，从而最小化隔膜的冷流对随后的压力测量的影响。

    METHODS FOR SOLID PHASE CAPTURE IN IMMUNOASSAYS
    364.
    发明申请
    METHODS FOR SOLID PHASE CAPTURE IN IMMUNOASSAYS 审中-公开
    免疫组织固相检测方法

    公开(公告)号：WO1994016329A1

    公开(公告)日：1994-07-21

    申请号：PCT/US1994000429

    申请日：1994-01-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  SWANSON, Jhan, C. ,  SONSALLA, Joy, C. ,  TZYY-WEN, Jeng

    IPC: G01N33/53

    CPC classification number: G01N33/54366 ,  G01N33/538 ,  G01N33/54313

    Abstract: A method for the determination of the presence or amount of an analyte by monitoring a detectable label immobilized within an asymmetric membrane. A test mixture, comprising a test sample, an indicator reagent attached to a first specific binding pair member, and a capture reagent attached to a second specific binding pair member immobilized on a solid phase, is formed which is then captured within the asymmetric membrane thereby enabling analyte concentration to be determined.

    Abstract translation: 通过监测固定在不对称膜内的可检测标记来确定分析物的存在或量的方法。 形成包含测试样品，连接到第一特异性结合对构件的指示剂和固定在固相上的第二特异性结合对构件附着的捕获试剂的测试混合物，然后将其捕获在非对称膜内 使分析物浓度得以确定。

    FORCE SENSOR ASSEMBLY FOR PRESSURE MEASUREMENT FOR PUMP
    366.
    发明申请
    FORCE SENSOR ASSEMBLY FOR PRESSURE MEASUREMENT FOR PUMP 审中-公开
    力传感器总成用于泵的压力测量

    公开(公告)号：WO1994014041A1

    公开(公告)日：1994-06-23

    申请号：PCT/US1993011942

    申请日：1993-12-08

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ABRAHAMSON, Kent, D.

    IPC: G01L09/00

    CPC classification number: A61M5/16854 ,  G01L9/006

    Abstract: The present invention (39) relates to a compression load cell (56) used to monitor pressure in a diaphragm cassette pumping system (10). A plunger (52) is axially slidable in a linear bearing (54) and has a first end in contact with the cassette (12) and the second end in contact with the load cell (56). The force signals have a direct relationship with the pressure in the cassette (12).

    Abstract translation: 本发明（39）涉及一种用于监测隔膜盒泵送系统（10）中的压力的​​压缩测力传感器（56）。 柱塞（52）可在直线轴承（54）中轴向滑动并且具有与盒（12）接触的第一端和与称重传感器（56）接触的第二端。 力信号与盒（12）中的压力有直接的关系。

    MULTI-CHANNEL AUTOMATIC IMMUNOASSAY SYSTEM
    367.
    发明申请
    MULTI-CHANNEL AUTOMATIC IMMUNOASSAY SYSTEM 审中-公开
    多通道自动免疫系统

    公开(公告)号：WO1994012885A1

    公开(公告)日：1994-06-09

    申请号：PCT/JP1993001701

    申请日：1993-11-19

    Applicant: DAINABOT CO., LTD. ,  PRECISION SYSTEM SCIENCE CO., LTD. ,  ABBOTT LABORATORIES ,  TAJIMA, Hideji ,  NAGAOKA, Nobuo ,  KANAZAWA, Kenichi ,  KUBO, Yoshinobu

    Inventor： DAINABOT CO., LTD. ,  PRECISION SYSTEM SCIENCE CO., LTD. ,  ABBOTT LABORATORIES

    IPC: G01N35/02

    CPC classification number: G01N35/04 ,  G01N21/76 ,  G01N35/026 ,  G01N35/1065 ,  G01N35/109 ,  G01N2035/00356 ,  G01N2035/0413 ,  G01N2035/0422 ,  G01N2035/0465 ,  G01N2035/0484 ,  G01N2035/103

    Abstract: A dispensation module adapted to supply in order reaction trays each of which has a plurality of wells, and dispense a specimen to the reaction trays on the basis of set specimen information, a sample processing module adapted to dispense, on the basis of the set specimen information, a reaction reagent, which corresponds to a measurement item for a specimen, in the corresponding well, and transfer the specimen while retaining the same at a constant temperature, and a detecting module adapted to dispense a reaction measuring reagent in each well in the reaction trays on the basis of the set specimen information, and having a means for measuring the luminescent intensity are provided in an adjacently lines state. A walking beam mechanism, which is adapted to transfer reaction trays slidingly and intermittently, is employed for the transferring of the reaction trays in the sample processing module and detecting module. During the dispensation of reagent by the sample processing module, reagent dispensation nozzles are moved in the direction perpendicular to the reaction tray transfer direction and the dispensation is carried out within the stopping time of the intermittent sliding transfer of the reaction trays and at regular time intervals with respect to each well placed in a position of a set order, in a reaction tray. The measurement with the detecting module is conducted at regular time intervals correspondingly to each well placed in a position of the set order. The specimens dispensed in the wells in the reaction trays are subjected to operations from the dipensation of a reagent to the measurement of luminescent intensity under the same conditions at the same time intervals, so that all the specimens processed in large quantities can be measured accurately.

    Abstract translation: 一种分配模块，其适于按顺序提供反应塔板，每个反应托盘具有多个孔，并且基于设定的样本信息将样品分配到反应塔盘;样品处理模块，其适于基于设定的样品 信息，对应于试样的测量项目的反应试剂，并在恒定温度下将试样保持在同一孔中;以及检测模块，其适于在每个孔中分配反应测定试剂 基于所设定的样本信息的反应塔盘，并且具有用于测量发光强度的装置以相邻的线状态设置。 用于滑动地和间歇地传送反应塔板的步进梁机构用于将样品处理模块和检测模块中的反应塔盘传送。 在样品处理模块分配试剂期间，试剂分配喷嘴沿与反应塔板传送方向垂直的方向移动，并且在反应塔板的间歇滑动转移的停止时间内以规则的时间间隔进行分配 相对于放置在设定顺序的位置的每个孔在反应盘中。 使用检测模块进行的测量以规定的时间间隔进行，对应于每个井位于设定顺序的位置。 分配在反应塔中的孔中的样品在相同条件下以相同的时间间隔进行从试剂的倾斜到发光强度的测量的操作，使得可以精确地测量大量处理的所有样品。

    AUTOMATED DRUG INFUSION SYSTEM
    368.
    发明申请
    AUTOMATED DRUG INFUSION SYSTEM 审中-公开
    自动化药物灌注系统

    公开(公告)号：WO1994012235A1

    公开(公告)日：1994-06-09

    申请号：PCT/US1993011033

    申请日：1993-11-15

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  JOHNSON, Noel, L. ,  HUANG, Terry, Jyh-Yi ,  BURNSIDE, Robert, R.

    IPC: A61M31/00

    CPC classification number: A61M5/16827 ,  A61M2205/6072 ,  G06F19/00 ,  G06F19/3468 ,  Y10S128/12 ,  Y10S128/13

    Abstract: The present invention relates to a control system for use with an automated intravenous drug and fluid infusion system having plural pumping channels (4, 6, 8, 10) that operate independently for intravenously infusing drugs and fluid. The pumping channels (4, 6, 8, 10) are controlled by a microprocessor-based host controller (2) that monitors each of the channels concurrently. In an exemplary embodiment, the system functions include preventing priming of a channel unless verification is provided that the channel is not connected to a patient and initiating the priming of each of the pumping channels independently.

    Abstract translation: 本发明涉及一种与自动静脉注射药物和流体输注系统一起使用的控制系统，该系统具有独立地用于静脉内输注药物和流体的多个泵送通道（4,6,8,10）。 泵送通道（4,6,8,10）由基于微处理器的主机控制器（2）控制，该控制器同时监视每个通道。 在示例性实施例中，除非提供信道未连接到患者并且独立地启动每个泵送通道的启动，否则系统功能包括防止通道引发通道。

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