公开(公告)号：IL136190D0

公开(公告)日：2001-05-20

申请号：IL13619098

申请日：1998-11-27

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: G01J3/46 ,  C12Q1/68 ,  G01B11/06 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01J5/10 ,  G01N1/30 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N33/483 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G06T1/00 ,  G06K

Abstract: A method for cancer cell detection including the steps of (a) staining an analyzed sample with at least first and second dyes, the dyes being selected such that the first dye better adheres to normal cells whereas the second dye better adheres to cancer cells; (b) spectrally imaging the sample through an optical device being optically connected to an imaging spectrometer thereby obtaining a spectrum of each pixel of the sample; (c) based on the spectra, evaluating concentrations of the first and second dyes for each of the pixels; and (d) based on the concentrations detecting the presence of cancer cells in the sample.

公开(公告)号：IL134152D0

公开(公告)日：2001-04-30

申请号：IL13415298

申请日：1998-09-29

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: A61B3/12 ,  A61B3/11 ,  A61B5/00 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  A61B

Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.

公开(公告)号：DE69327909T2

公开(公告)日：2000-07-13

申请号：DE69327909

申请日：1993-07-22

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G ,  BUCKWALD ROBERT A

IPC: G01J3/26 ,  G01J3/28 ,  G01B9/02

公开(公告)号：AU2730597A

公开(公告)日：1997-11-12

申请号：AU2730597

申请日：1997-04-16

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： GARINI YUVAL ,  CABIB DARIO ,  BUCKWALD ROBERT A ,  SOENKSEN DIRK G ,  RIED THOMAS

IPC: C12N15/09 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G02B21/16 ,  G06K9/00 ,  G06K9/76 ,  G02B21/00

Abstract: A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and/or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.

公开(公告)号：IL141902A

公开(公告)日：2007-02-11

申请号：IL14190299

申请日：1999-09-10

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: C12Q1/68 ,  G01B11/06 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01J5/10 ,  G01N1/30 ,  G01N15/14 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76

Abstract: A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using the spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of the other constant components are modified to substantially resemble the spectral vector; (d) operating the correcting function on spectral vectors associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying the corrected spectral vectors into classification groups.

公开(公告)号：IL124848A

公开(公告)日：2003-07-06

申请号：IL12484897

申请日：1997-05-12

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: A61B3/14 ,  G01B9/02 ,  G01J3/45 ,  G02B20060101

公开(公告)号：DE69332492D1

公开(公告)日：2002-12-19

申请号：DE69332492

申请日：1993-07-22

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G

IPC: G01J3/26 ,  G01J3/28

公开(公告)号：AU2024700A

公开(公告)日：2000-06-13

申请号：AU2024700

申请日：1999-11-16

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： GARINI YUVAL ,  MCNAMARA GEORGE ,  SOENKSEN DIRK G ,  CABIB DARIO ,  BUCKWALD ROBERT A

IPC: C12Q1/68 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/30 ,  G01N21/64 ,  G01N21/78 ,  G01N33/50 ,  G01N33/53 ,  G01N33/533 ,  G01N33/535 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  C12Q1/54 ,  C12Q1/28 ,  C12Q1/00 ,  C12Q1/42

Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

公开(公告)号：DE69327909D1

公开(公告)日：2000-03-30

申请号：DE69327909

申请日：1993-07-22

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G ,  BUCKWALD ROBERT A

IPC: G01J3/26 ,  G01J3/28 ,  G01B9/02

公开(公告)号：AU5472399A

公开(公告)日：2000-03-21

申请号：AU5472399

申请日：1999-08-16

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： ADEL MICHAEL E ,  CABIB DARIO ,  WINE DAVID

IPC: G02B6/00 ,  A61B1/06 ,  A61B3/12 ,  A61B3/14 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28 ,  G02B6/04 ,  A61B3/10

Abstract: A device and method for spectral imaging of an object. A plurality of sets of narrow-band light sources such as LEDs are provided. Each set emits illumination radiation in a different narrow spectral band. Each set is activated sequentially to illuminate the object. Light reflected from the object or transmitted by the object is focused on a detector array to image the object. Narrower illumination bands are provided by dispersing the emitted light using a dispersive optical element such as a diffraction grating. Alternatively; selected sets or subsets are activated simultaneously with duty cycles that emulate a preselected spectral distribution. For imaging ocular fundus tissue, the illumination light is shaped into an annular beam by an appropriately shaped waveguide.