公开(公告)号：EP1639346A2

公开(公告)日：2006-03-29

申请号：EP04755263.3

申请日：2004-06-16

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J.

IPC: G01N21/55

CPC classification number: A61B5/6826 ,  A61B5/14552 ,  A61B5/6838 ,  G01N21/01

Abstract: The present invention relates to a method and apparatus that utilizes a reflective enclosure (10) to stimulate optical homogeneity in an otherwise inhomogeneous sample. The illumination sources (20) and sample are placed within the reflective enclosure (10), thus providing a method for examining a sample that is different from transmission, reflection or transflection. This apparatus and method are particularly well adapted to in vivo non-invasive testing for constituents of blood.

公开(公告)号：EP0742897B1

公开(公告)日：2003-04-09

申请号：EP95907352.9

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: G01N21/35

CPC classification number: G01N21/4795 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359 ,  G01N2021/3137

公开(公告)号：EP0884970A1

公开(公告)日：1998-12-23

申请号：EP96910703.0

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: G01N21 ,  A61B5 ,  A61B10 ,  G01N33

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/14558 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/3137

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

公开(公告)号：EP1178750A1

公开(公告)日：2002-02-13

申请号：EP00923567.2

申请日：2000-04-20

Applicant: OPTIX LP

Inventor： GUTHERMANN, Howard, E.

IPC: A61B5/00

CPC classification number: A61B5/201 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495

Abstract: The absence of a defined optical path length for in vivo measurements creates problems for the noninvasive measurement of analyte concentration. These problems can be reduced by combining measurements made at several wavelengths and using the fact that normal renal function causes the concentration of water in whole blood to be tightly controlled. Hence, the concentration of water in arterial blood can serve as a useful internal standard for such measurements. The measurements are then procured so as to remove the dependency of concentration on path length traversed by the illuminating radiation and on the scattering properties of the volume through which the illuminating radiation propagates. Using this method, one can create improved calibration for measurements of absorbing constituents in arterial blood and thereby provide absolute concentration measurements of constituents such as hemoglobin and glucose in arterial blood.

公开(公告)号：EP0742897A4

公开(公告)日：1999-05-12

申请号：EP95907352

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

CPC classification number: G01N21/4795 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359 ,  G01N2021/3137

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

公开(公告)号：EP0742897A1

公开(公告)日：1996-11-20

申请号：EP95907352.0

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: A61B5 ,  G01N21 ,  G01N33

CPC classification number: G01N21/4795 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359 ,  G01N2021/3137

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.