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    HCV VACCINES
    35.
    发明申请
    HCV VACCINES 审中-公开
    HCV疫苗

    公开(公告)号：WO0245743A3

    公开(公告)日：2004-01-08

    申请号：PCT/GB0105421

    申请日：2001-12-07

    Applicant: UNIV CAMBRIDGE TECH ,  UNIV ROMA ,  ALLAIN JEAN-PIERRE ,  LI CHENGYAO ,  PICCOLELLA ENZA

    Inventor： ALLAIN JEAN-PIERRE ,  LI CHENGYAO ,  PICCOLELLA ENZA

    IPC: A61K39/00 ,  A61K39/29 ,  A61P31/14 ,  C07K14/18 ,  C07K16/10

    CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/505 ,  A61K2039/57 ,  C12N2770/24222 ,  C12N2770/24234

    Abstract: HCV vaccines are described which are capable of raising antibodies and/or helper T lymphocytes and/or cytotoxic T lymphocytes which are cross-reactive to the hypervariable 1 (HVR 1) region of the envelope protein E2 of different HCV strains. A preferred therapeutic vaccine for treatment of chronic HCV infection comprises a plurality of different groups of peptides, each peptide comprising a different known HVR 1 C-terminal sequence or a different consensus of known HVR 1 C-terminal sequences. The different groups of peptides are sequentially administered (preferably at intervals of 15-21 days) to raise antibodies, helper t lymphocytes, and cytotoxic T lymphocytes which are cross-reactive to the HVR 1 region(s) of the chronically infecting HCV strain(s). methods of selecting peptides for use in such vaccines are also described.

    Abstract translation: 描述了HCV疫苗，其能够产生与不同HCV毒株的包膜蛋白E2的高变体1（HVR 1）区域交叉反应的抗体和/或辅助性T淋巴细胞和/或细胞毒性T淋巴细胞。 用于治疗慢性HCV感染的优选治疗性疫苗包括多个不同组的肽，每个肽包含不同的已知HVR1 C-末端序列或已知HVR1 C-末端序列的不同共有。 顺序施用不同组的肽（优选以15-21天为间隔），以产生与慢性感染的HCV毒株的HVR 1区交叉反应的抗体，辅助性T淋巴细胞和细胞毒性T淋巴细胞（ S）。 还描述了选择用于这种疫苗的肽的方法。

    ECHO-SCINTIGRAPHIC PROBE FOR MEDICAL APPLICATIONS AND RELEVANT DIAGNOSTIC METHOD
    36.
    发明申请
    ECHO-SCINTIGRAPHIC PROBE FOR MEDICAL APPLICATIONS AND RELEVANT DIAGNOSTIC METHOD 审中-公开
    医学应用的ECHO-SCINTIGRAPHIC探针和相关诊断方法

    公开(公告)号：WO2015173841A3

    公开(公告)日：2016-01-07

    申请号：PCT/IT2015000130

    申请日：2015-05-14

    Applicant: ISTITUTO NAZ DI FISICA NUCLEARE ,  UNIV ROMA

    Inventor： PANI ROBERTO ,  ORSOLINI CENCELLI VALENTINO ,  FABBRI ANDREA

    IPC: G01T1/161 ,  A61B6/00 ,  A61B8/00 ,  G01T1/16

    CPC classification number: A61B6/5247 ,  A61B6/4258 ,  A61B8/4416 ,  A61B8/4444 ,  A61B8/463 ,  G01T1/1603 ,  G01T1/1612

    Abstract: The present invention relates to an echo-scintigraphic probe (1) for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe (11) suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe (1), one is able to provide a double image of the object under examination. The ultrasound probe (11) is housed in the head (8), above the plane of the collimator (14) and kept projecting to favor the direct contact with the body part (20) of the patient (13) to be examined. The collimator (14) is able to obtain images of the biodistribution of a radiolabeled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe (11). The probe (1) is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers. The invention also concerns a guided diagnostic method that realizes a functional integration of a pair of ultrasound and scintigraphic images concurrently obtained by the echo-scintigraphic probe (1) according to the invention.

    Abstract translation: 本发明涉及用于医疗应用的回波 - 闪烁扫描探针（1）和合并图像的方法。 它由几何学上适当地整合的超声波探头（11）和图像处理方面与闪烁照相探针或γ照相机（3）的联合构成。 通过所述探针（1）的单一应用，能够提供检查对象的双重图像。 超声探头（11）被容纳在头部（8）中，在准直器（14）的平面之上，并且保持突出以有助于与待检查的患者（13）的身体部分（20）的直接接触。 准直器（14）能够通过具有正面入射的辐射获得放射性标记药物的生物分布的图像，保持超声波探头（11）的特性。 探针（1）适用于使用无线电示踪剂的临床诊断和癌症术中诊断。 本发明还涉及实现由根据本发明的回波 - 闪烁扫描探针（1）同时获得的一对超声和闪烁照相图像的功能整合的指导诊断方法。

    MIRNA, SIRNA AND USE THEREOF IN THERAPY
    37.
    发明申请
    MIRNA, SIRNA AND USE THEREOF IN THERAPY 审中-公开
    MIRNA，SIRNA及其在治疗中的用途

    公开(公告)号：WO2009063426A2

    公开(公告)日：2009-05-22

    申请号：PCT/IB2008054774

    申请日：2008-11-14

    Applicant: UNIV ROMA ,  BOZZONI IRENE ,  FATICA ALESSANDRO ,  ROSA ALESSANDRO

    Inventor： BOZZONI IRENE ,  FATICA ALESSANDRO ,  ROSA ALESSANDRO

    IPC: C12N15/113

    CPC classification number: C12N15/1135 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

    Abstract: The present invention relates to a mixture of molecules comprising at least one miRNA and at least one siRNA, or at least two miRNAs, or at least two siRNAs for inducing hematopoietic differentiation or for treating leukemia wherein the miRNA is able to modulate hematopoietic differentiation and/or to act as oncosuppressor, and the siRNA is able to modulate hematopoietic differentiation or to inhibit the expression of a fusion product deriving from a chromosomic translocation associated to leukemia.

    Abstract translation: 本发明涉及包含至少一种miRNA和至少一种siRNA，或至少两种miRNA或至少两种用于诱导造血分化或用于治疗白血病的siRNA的分子混合物，其中所述miRNA能够调节造血分化和/ 或充当抑癌抑制因子，并且siRNA能够调节造血分化或抑制源自与白血病相关的染色体易位的融合产物的表达。

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