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公开(公告)号：KR101571474B1
公开(公告)日：2015-11-25
申请号：KR1020090024900
申请日：2009-03-24
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61Q19/02 , A61K36/185 , A61P17/00
Abstract: 본발명은말라스나무(Homalium longifolium)추출물을유효성분으로함유하는미백용조성물에대한것이다. 보다상세하게는멜라노사이트(melanocyte)의세포표면단백질인씨-킷트(c-kit) 단백질의활성을저해하고멜라노사이트내 세포의신호전달을억제함으로써우수한미백효과를나타내는피부외용제조성물에대한것이다.
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公开(公告)号：KR1020150100599A
公开(公告)日：2015-09-02
申请号：KR1020150116268
申请日：2015-08-18
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 녹차다당체의 제조방법에 관한 것으로, 보다 상세하게는 a) 용매를 이용하여 녹차 분말에서 엽록소 및 저분자량의 폴리페놀을 제거하는 단계; b) 상기 a)단계의 녹차 잔사로부터 수용성 활성성분을 열수 추출하는 단계; 및 c) 상기 b)단계의 열수 추출물로부터 한외여과 및 에탄올 침전 반응으로 녹차다당체를 분리하는 단계를 포함하는 것을 특징으로 하는 녹차다당체의 제조방법에 관한 것이다. 본 발명에 따라 제조한 녹차다당체를 함유하는 화장료 조성물은 우수한 피부 미백, 보습 및 주름 개선 효과를 나타낸다.
Abstract translation: 本发明涉及一种生产绿茶多糖的方法，更具体地说，涉及生产绿茶多糖的方法，其包括以下步骤：（a）通过使用绿茶从绿茶中除去叶绿素和低分子量多酚 溶剂; （b）通过使用热水从步骤（a）中的绿茶残渣中提取水溶性活性成分; 和（c）通过步骤（b）中的热水提取物的超滤和乙醇沉淀分离绿茶多糖。 含有本发明生产的绿茶多糖的化妆品组合物对皮肤美白，保湿和皱纹改善具有突出的效果。
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公开(公告)号：KR101154581B1
公开(公告)日：2012-06-08
申请号：KR1020080096610
申请日：2008-10-01
Applicant: (주)아모레퍼시픽
Abstract: 본발명은영국해안에서자라는식물인크리스트마린(Criste Marine) 줄기세포배양액추출물을유효성분으로함유하는보습용화장료조성물을개시한다. 더욱상세하게는, 피부줄기세포의활성을조절하는 p63을특이적으로활성화시킴으로써표피줄기세포를활성화시켜보습효과를나타내는화장료조성물을개시한다.
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公开(公告)号：KR1020100056281A
公开(公告)日：2010-05-27
申请号：KR1020080115368
申请日：2008-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K8/0212 , A61K2800/522 , A61Q19/00 , A61Q17/04 , A61Q19/08
Abstract: 본발명은항산화용화장료조성물에관한것으로, 보다상세하게는한방가공기술인포제()를활용하여가공된작약, 옥죽및 백합추출물중 1 종이상또는상기포제처리된추출물과이들의생품추출물중 1종이상을혼합한혼합추출물을유효성분으로함유하는항산화용화장료조성물에관한것이다.
Abstract translation: 目的：提供含有草药提取物的抗氧化化妆品组合物以抑制DPPH（1,1-二苯基-2-苦基酰肼）氧化。 构成：抗氧化化妆品组合物含有牡丹，茯苓或百草萃取物作为活性成分。 制备牡丹，Polygonati Rhizoma或Lilium提取物的方法包括：向牡丹，Polygonati Rhizoma或百合提取物中加入蜂蜜并保持30分钟-1小时的步骤; 在100-180℃下烘烤10分钟至1小时的步骤; 和用水或有机溶剂萃取的步骤。 有机溶剂为乙醇，甲醇，丁醇，乙醚，乙酸乙酯或氯仿。
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公开(公告)号：KR1020100037906A
公开(公告)日：2010-04-12
申请号：KR1020080097245
申请日：2008-10-02
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K8/02 , A61K2800/524 , A61Q5/00 , A61Q19/00
Abstract: PURPOSE: A cosmetic composition for hair containing Paeonia lactiflora-brewed water having resveratrol is provided to prevent scalp aging and cell damage. CONSTITUTION: A cosmetic composition for scalp or hair contains 0.01-10.0 weight% of Paeonia lactiflora-brewed water. The Paeonia lactiflora-brewed water is extracted by adding Paeonia lactiflora to soluble composition containing water and infusing active ingredients of Paeonia lactiflora at low temperature. The composition additionally contains extracts of Opunitia ficus-indica var. saboten, Glycyrrhiza uralensis, or cacao seed. The composition is used in the form of hair tonic, hair essence, hair serum, scalp treatment, hair treatment, hair conditioner, hair shampoo or hair lotion.
Abstract translation: 目的：提供含白藜芦醇的含有芍药的水溶性头发的化妆品组合物，以防止头皮老化和细胞损伤。 构成：用于头皮或头发的化妆品组合物含有0.01-10.0重量％的芍药乳糜水。 通过将芍药芍药加入到含水的可溶性组合物中并在低温下输入芍药芍药的活性成分来提取芍药乳清水。 该组合物另外含有榕树a藜的提取物。 沙丁鱼，甘草或可可种子。 该组合物以头发补品，头发精华，头发血清，头皮治疗，头发处理，护发素，洗发剂或洗发剂的形式使用。
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Patent Agency Ranking
公开(公告)号：KR1020090093245A
公开(公告)日：2009-09-02
申请号：KR1020080018672
申请日：2008-02-29
Applicant: (주)아모레퍼시픽 , 경상대학교산학협력단
CPC classification number: C07K14/47 , C12Q1/6876 , C12Q2600/136 , G01N33/5008 , G01N33/68
Abstract: A bio marker for diagnosing hyperpigmentation disposition of skin is provided to rapidly and sensitively predict the possibility of pigmentation. A bio marker for diagnosing skin of hyperpigmentation disposition comprises a gene of which expression is increased or decreased by UV irradiation. A kit for diagnosing hyperpigmentation disposition comprises a polynucleotide of the bio marker gene or its fragment and solid support in which one or more polynucleotide is conjugated on the surface. A method for screening an inhibitor of hyperpigmentation disposition comprises: a step of treating test material in the bio marker gene; and a step of confirming whether the test material suppresses or inhibits the expression of the gene.
Abstract translation: 提供用于诊断皮肤色素沉着过度的生物标记，以快速和敏感地预测色素沉着的可能性。 用于诊断色素沉着过度皮肤的生物标志物包括通过UV照射增加或减少表达的基因。 用于诊断色素沉着过度的试剂盒包括生物标记基因的多核苷酸或其片段和固体支持物，其中一个或多个多核苷酸在表面上缀合。 一种筛选色素沉着过度抑制剂的方法，包括：在生物标记基因中处理试验材料的步骤; 以及确认测试材料是否抑制或抑制基因表达的步骤。
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公开(公告)号：KR1020080044612A
公开(公告)日：2008-05-21
申请号：KR1020060113663
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K36/575 , A61P17/00
CPC classification number: A61K8/97 , A61Q19/02 , Y10S514/846 , Y10S514/847
Abstract: A composition comprising an extract of Magnolia Obovata bark is provided to inhibit melanogenesis by inhibiting the activity of c-kit protein expressed in melanocyte effectively, thereby showing excellent whitening effect. A composition for inhibiting c-kit protein activity comprises 0.0001-10 wt.% of an extract of Magnolia Obovata bark as an effective ingredient, wherein the extract controls function of melanocyte by inhibiting signalling of cells in a melanocyte participated by a C-kit protein.
Abstract translation: 通过抑制黑素细胞表达的c-kit蛋白的活性，提供含有木兰提取物的组合物，以抑制黑素生成，从而显示优异的美白效果。 用于抑制c-kit蛋白活性的组合物包含0.0001-10重量％的木兰木皮提取物作为有效成分，其中所述提取物通过抑制C-kit蛋白质参与的黑素细胞中细胞的信号传导来控制黑素细胞的功能 。
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38.发明公开콜레스테릴 헤미숙신네이트 기반의 나노 전달체로 포집된상백피 추출물을 유효 성분으로 함유하는 피부 미백용조성물 无效用于皮肤白蛋白的组合物包含多糖根提取物包裹在胆固醇合成的基于脂质的纳米载体中
公开(公告)号：KR1020070089459A
公开(公告)日：2007-08-31
申请号：KR1020060019537
申请日：2006-02-28
Applicant: (주)아모레퍼시픽
Abstract: A lipid-based nano-carrier is provided to increase the whitening effect of an extract of Mori Cotex Radicis by encapsulating an extract of Mori Cortex Radicis in the lipid-based nano-carrier in which cholesteryl hemisuccinate is introduced, thereby effectively inhibiting the melanogenesis without side effects. The lipid-based nano-carrier is characterized in that it is in the form of a liposome dispersion or a nano-emulsion in which cholesteryl hemisuccinate encapsulating an extract of Mori Cortex Radicis or a salt thereof is introduced. Regarding the total weight of the total liposome dispersion or the nano-emulsion, the content of the lipid is 0.001-20 wt.% and the content of the extract is 0.001-30 wt.%. The skin whitening composition comprises the nano-carrier.
Abstract translation: 提供一种脂质纳米载体，通过将Mori Cortex Radicis的提取物包封在引入胆固醇基半琥珀酸酯的脂质纳米载体中，从而有效抑制黑素生成，从而有效抑制黑素生成，从而提高Mori Cotex Radicis提取物的美白效果， 副作用。 基于脂质的纳米载体的特征在于其为脂质体分散体或纳米乳剂的形式，其中引入了包封Mori Cortex Radicis提取物的胆固醇半琥珀酸盐或其盐。 关于总脂质体分散体或纳米乳液的总重量，脂质的含量为0.001-20重量％，提取物的含量为0.001-30重量％。 皮肤美白组合物包含纳米载体。
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公开(公告)号：KR1020070070300A
公开(公告)日：2007-07-04
申请号：KR1020050069505
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
CPC classification number: C12N15/113 , A61K8/606 , A61K31/7105 , A61Q19/02 , C12N2310/141
Abstract: A method for inhibiting melanosome migration by using prohibitin siRNA(small interference RNA) is provided to inhibit expression of prohibitin in a melanin synthesis cell and uniformed distribution of melanosome in the melanin synthesis cell, so that the skin is whitened. The melanosome migration to the end of melanin synthesis cell is inhibited by administering prohibitin siRNA into the melanin synthesis cell, melan-a, thereby inhibiting binding of prohibitin to melanophilin as a melanosome vehicle and uniformed distribution of melanosome in the melanin synthesis cell.
Abstract translation: 提供了通过使用prohibitin siRNA（小干扰RNA）抑制黑素体迁移的方法，以抑制黑色素合成细胞中的禁忌蛋白的表达和黑色素合成细胞中黑素体的均匀分布，从而使皮肤变白。 黑色素细胞迁移到黑色素合成细胞末端受到抑制黑色素合成细胞，黑色素a的抑制蛋白siRNA，从而抑制黑素素作为黑素体载体和黑素体合成细胞中黑素体分布均匀的结合。
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公开(公告)号：KR100716891B1
公开(公告)日：2007-05-09
申请号：KR1020050103808
申请日：2005-11-01
Applicant: (주)아모레퍼시픽
IPC: C07D417/04
Abstract: 본 발명은 하기 화학식 1로 표시되는 피리딘 티아졸 카복사마이드 유도체 또는 그의 약제학적으로 허용되는 염, 이의 제조방법 및 이를 함유하는 씨-킷트 활성 억제용 조성물 또는 피부 미백용 조성물에 관한 것으로, 하기 화학식 1의 화합물은 씨-킷트(c-Kit) 활성 억제작용에 의해 멜라닌 생성을 억제함으로써 피부의 색소침착을 개선시켜 미백 효과를 나타내는 효능이 있으므로, 이를 함유하는 씨-킷트 활성 억제용 조성물 및 피부 미백용 조성물은 화장료 조성물 또는 약학 조성물로써 유용하게 이용될 수 있다.
[화학식 1]
(상기 식에서,
R
1 은 페닐이고, n 은 1, 2 또는 3이다.)
피리딘 티아졸 카복사마이드, 씨 킷트, 멜라닌, 미백, 화장료.Abstract translation: 本发明涉及式（I）吡啶噻唑甲酰衍生物或其盐药学上可接受的由下式表示，其制备方法和含有它的种子 - 涉及一种组合物用于试剂盒的抑制组合物或皮肤美白，式 化合物1是的c-kit（的c-kit）由活化抑制作用抑制黑色素产生和改善皮肤色素沉着，因此效力表示美白效果，含有相同的试剂盒的抑制组合物和皮肤美白的种子 可以有利地用作化妆品组合物或药物组合物。
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