-
公开(公告)号：KR1020060019642A
公开(公告)日：2006-03-06
申请号：KR1020040068207
申请日：2004-08-28
Applicant: 황재관
IPC: A61K31/09
Abstract: 본 발명은 신규 정족수 감지(quorum sensing) 저해제에 관한 것으로, 좀 더 상세하게는 커큐마 도메스티카(
Curcuma domestica ), 커큐마 잔소리자(
Curcuma xanthorrhiza ) 등에서 유래하는 커큐민(curcumin)의 정족수 감지 저해 작용을 이용한 새로운 항균제에 관한 것이다. 본 발명의 커큐민은 크로모박테리움 비올라세움 CV026(
Chromobacterium violaceum CV026), 슈도모나스 아루지노사(
Pseudomonas aeruginosa ) 등과 같은 그램 음성세균(Gram-negative bacteria)의 정족수 감지를 효율적으로 저해함으로써 부작용 없이 항균작용을 제공한다.
정족수 감지(quorum sensing), 커큐민(curcumin), 항균제-
公开(公告)号：KR1020050108466A
公开(公告)日：2005-11-16
申请号：KR1020040033012
申请日：2004-05-11
Applicant: 주식회사 엘지생활건강 , 황재관
Abstract: 본 발명은 페놀(phenol)계 정유(essential oil) 유도체를 함유하는 구강질환 예방과 치료용 항균제 및 구강 조성물에 관한 것으로, 화학식 1로 표시되는 페놀계 정유 유도체들은 충치 유발균인 스트렙토코커스 뮤탄스(
Streptococcus mutans )와 치주질환 유발균인 포르피로모나스 진지발리스(
Porphyromonas gingivalis )등에 대한 항균활성이 매우 높아 충치 및 치주질환의 예방 및 치료, 그리고 구취 제거의 효과를 나타낼 수 있으며, 또한 이들은 치약이나 양치액, 마우스 스프레이 또는 식이성 필름 등의 구강 조성물에 적용될 수 있다.-
公开(公告)号：KR100385913B1
公开(公告)日：2003-06-02
申请号：KR1020000062095
申请日：2000-10-21
Applicant: 황재관
IPC: C07H1/08
Abstract: PURPOSE: Provided is a method for manufacturing oligosaccharide from ginseng, in particular, from ginseng dregs generated from the manufacturing ginseng extract, by treating polysaccharide hydrolyase. CONSTITUTION: The manufacturing method comprises the steps of: heat-vaporizing or freeze-drying ginseng dregs to remove remaining moisture or solvent therefrom then followed by pulverizing; adding polysaccharide hydrolyase, such as cellulase, hemiplegia, and pectinase, to the ginseng dregs then hydrolyzing the ginseng dregs at 30-60 deg.C for 0.5-6 hours with stirring; heating the above enzyme treated sample at 100 deg.C for 10-30 minutes to inactivate the enzyme then centrifuging it at 5000-10000xg for 10-30 minutes to obtain oligosaccharide from the supernatant; and filtering the supernatant followed by passing it through ultrafiltrator with ultrafiltration membrane of MW 500-5000 then fractioning it according to molecular weight.
Abstract translation: 目的：提供一种由人参制备寡糖的方法，特别是由制造人参提取物产生的人参渣，通过处理多糖水解酶来制备。 本发明的制造方法包括以下步骤：将人参残渣热蒸发或冷冻干燥以除去残留的水分或溶剂，然后粉碎; 向人参糟中加入纤维素酶，偏瘫，果胶酶等多糖水解酶，然后在30-60℃下水解人参渣0.5-6小时， 将上述酶处理过的样品在100℃加热10-30分钟使酶失活，然后在5000-10000xg下离心10-30分钟，从上清液中获得寡糖; 过滤上清液，然后将其通过具有MW 500-5000的超滤膜的超滤器，然后根据分子量对其进行分级。
-
公开(公告)号：KR1020000000342A
公开(公告)日：2000-01-15
申请号：KR1019990044406
申请日：1999-10-13
Applicant: 황재관
IPC: A23L3/3472
Abstract: PURPOSE: Extraction methods using microwaves, ultrasonic waves, or supercritical fluids are provided to extract an antibiotic material from Curcuma xanthorrhiza which suppresses the growth of a harmful oral germ and a pimple inducible germ. CONSTITUTION: Extraction methods of an antibiotic material are shown: extraction of xanthorrhiza from pulverized Curcuma xanthorrhiza by using CO2 as supercritical fluid, at 35-79°C, and within the range of 100-400 bar; extraction of xanthorrhiza from the composition composed of pulverized Curcuma xanthorrhiza and solvent at the ratio of 10:1-30:1, at 50-120°C for 1-10 min by using microwaves; extraction of xanthorrhiza from the composition composed of pulverized Curcuma xanthorrhiza and solvent at the ratio of 10:1-30:1, at room temperature-50°C for 10-60 min by using ultrasonic waves. The extracts are condensed by evaporating solvents, and are analyzed by using silica gel chromatography.
Abstract translation: 目的：提取使用微波，超声波或超临界流体的提取方法，从姜黄黄疸提取抗生素，抑制有害的口腔细菌和疙瘩诱导型细菌的生长。 构成：抗生素材料的提取方法如下：使用CO2作为超临界流体，在35-79℃，100-400巴的范围内，从粉碎的姜黄中提取黄疸; 通过使用微波从50-120℃以10：1-30：1的比例从粉碎的姜黄和溶剂组成的组合物中提取黄疸1-10分钟; 通过使用超声波在室温-50℃下，以10：1-30：1的比例从粉碎的姜黄和溶剂组成的组合物中提取黄疸10-60分钟。 萃取液通过蒸发溶剂浓缩，并通过硅胶色谱分析。
-
公开(公告)号：KR1020100041258A
公开(公告)日：2010-04-22
申请号：KR1020080100363
申请日：2008-10-13
Applicant: 황재관
IPC: A61K31/357 , A61P31/04
Abstract: PURPOSE: A composition containing JS-1 or Baeckea frutescens L. extract is provided to use in acne treatment with excellent antibacterial activity. CONSTITUTION: An antibacterial composition contains JS-1 compound of chemical formula 1 or its pharmaceutically acceptable salt as an active ingredient. The composition has antibacterial activity to Propionibacterium acnes, Staphylococcus epidermidis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus xylosus, Staphylococcus hominis or Staphylococcus saprophyticus. The JS-1 of chemical formula 1 is isolated from Baeckea frutescens L. The antibacterial composition contains Baeckea frutescens L. extract as an active ingredient. The Baeckea frutescens L. extract is isolated using water, organic solvent of C1-C6, subcritical water, or supercritical carbon dioxide. A composition for treating acne contains the JS-1 compound of chemical formula 1 or its pharmaceutically acceptable salt as an active ingredient.
Abstract translation: 目的：提供含有JS-1或Baeckea frutescens L.提取物的组合物，用于具有优异抗菌活性的痤疮治疗。 构成：抗菌组合物含有化学式1的JS-1化合物或其药学上可接受的盐作为活性成分。 该组合物对痤疮丙酸杆菌，表皮葡萄球菌，金黄色葡萄球菌，金黄色葡萄球菌，溶血葡萄球菌，木葡萄球菌，人葡萄球菌或腐生葡萄球菌具有抗菌活性。 化学式1的JS-1分离自Baeckea frutescens L.抗菌组合物含有Baeckea frutescens L.提取物作为活性成分。 使用水，C1-C6的有机溶剂，亚临界水或超临界二氧化碳分离Baeckea frutescens L.提取物。 用于治疗痤疮的组合物含有化学式1的JS-1化合物或其药学上可接受的盐作为活性成分。
-
Patent Agency Ranking
公开(公告)号：KR100619498B1
公开(公告)日：2006-09-06
申请号：KR1020050050646
申请日：2005-06-13
Applicant: 황재관
IPC: A61K31/357
Abstract: 본 발명은 미리스티카 프라그란스(
Myristica fragrans )로부터 분리된 간독성 예방 및 치료제에 관한 것으로, 보다 상세하게는 하기 화학식 1로 표시되는 메이스리그난(macelignan)은 화학·독성물질에 의해 유발되는 간세포 독성을 효과적으로 억제하여 간손상 예방 및 치료를 위한 약학 조성물로서 유용하게 사용될 수 있다.
상기 화학식 1의 메이스리그난은 독성물질 투여에 따른 세포 증식억제와 세포괴사(necrosis)를 완화시켜주었고, 세포내 활성산소종(reactive oxygen species)의 생성과 지질과산화의 정도를 감소시켰으며 DNA 손상을 회복시키는 효과를 나타내었다. 따라서 본 발명의 메이스리그난은 간질환의 예방 및 치료에 매우 유용하게 사용될 수 있다.
메이스리그난, 미리스티카 프라그란스, 간독성, 간보호약제Abstract translation: 本发明涉及肉豆蔻（myristica fragrans）
-
公开(公告)号：KR1020050035954A
公开(公告)日：2005-04-20
申请号：KR1020030071229
申请日：2003-10-13
Applicant: 황재관
CPC classification number: A61K8/4973 , A61K8/97 , A61K2800/84 , A61Q11/00 , Y10S514/90
Abstract: 본 발명은 충치 및 치주염 예방과 치료용 항균제 및 구강 조성물에 관한 것으로서, 항균제 및 구강 조성물은 리그난(lignan) 유도체를 유효성분으로 함유하는 것을 특징으로 한다. 본 발명의 리그난 유도체는 충치 유발균인 스트렙토코커스 뮤탄스(
Streptococcus mutans )와 치주질환 유발균인 포피로모나스 진지바리스(
Porphyromonas gingivalis )에 대한 항균활성이 매우 높을 뿐만 아니라, 고온에서도 안정하여 넓은 범위의 온도에서도 가공처리가 가능하다. 따라서 리그난 유도체는 충치와 치주염 예방과 치료에 효과적이며, 항균제뿐만 아니라, 치약조성물, 구강청정제, 검(gum), 캔디(candy), 젤리(gelly), 쵸콜릿(chocolate) 등과 같은 다양한 제형의 구강 조성물에 이용될 수 있다.-
公开(公告)号：KR1020030043520A
公开(公告)日：2003-06-02
申请号：KR1020010074760
申请日：2001-11-28
Applicant: 황재관 , 주식회사 엘지생활건강
CPC classification number: A61K8/97 , A61K8/9706 , A61Q11/02
Abstract: PURPOSE: Provided is an oral composition against halitosis, which is excellent in inhibition of halitosis and oral hygiene, by using oral sterilizing agent, oral inflammation inhibitor and halitosis inducing material remover. CONSTITUTION: An oral composition is characterized by comprising 0.01-1 wt.% of xanthorrhizol, 0.001-2 wt.% of Ulmi cortex extract, dipotassium glycyrrhizinate or the mixture thereof, 0.01-2 wt.% of Paeonia suffruticosa roots, and 0.01-1 wt.% of a shampinion extract. It can be formulated into chewing gum, edible file, mouth spray, tooth paste and the like.
Abstract translation: 目的：提供口服口服成分，通过口服灭菌剂，口腔炎症抑制剂和口臭诱导物质去除剂，可以有效抑制口臭和口腔卫生。 组成：口服组合物的特征在于包含0.01-1重量％的黄嘌呤，0.001-2重量％的Ulmi皮质提取物，甘草酸二钾或其混合物，0.01-2重量％的芍药根和0.01- 1重量％的香波提取物。 可配制成口香糖，食用锉，口腔喷雾剂，牙膏等。
-
公开(公告)号：KR100385914B1
公开(公告)日：2003-06-02
申请号：KR1020000066137
申请日：2000-11-08
Applicant: 황재관
IPC: A23L2/38
Abstract: PURPOSE: Provided is a process of preparing the titled functional beverage by wet-milling ginseng cake as residue of a ginseng extract, hydrolyzing the obtained ginseng paste with a polysaccharidase or an acid and then mixing the obtained ginseng dietary fiber and ginseng oligosaccharide. By the addition of ginseng dietary fiber and ginseng oligosaccharide to a beverage or fermented milk, the fermented milk or beverage improved in functionality is obtained. CONSTITUTION: Ginseng cake is poured into a wet miller with a clearance of 0.02 to 0.3mm and ground and the ground ginseng cake is subjected to retort sterilization at 121deg.C for 10 to 30 min. Thereafter, the obtained ginseng paste is hydrolyzed with cellulase, hemicellulose and pectinase alone or a mixed solution of enzyme thereof in a weight ratio of 1:1 to 1:0.001 at 30 to 60deg.C for 30 min to 6 hr, or with an acid at 60 to 100deg.C for 30 min to 4 hr. The hydrolyzed sample is subjected to centrifugal separation and drying at room temperature to give insoluble ginseng dietary fiber. The supernatant obtained after centrifugal separation is filtered, added with isopropanol and washed with isopropanol and acetone to give soluble ginseng dietary fiber. The supernatant obtained during the addition of isopropanol is concentrated under vacuum to give soluble ginseng oligosaccharide and then mixed with the previously obtained ginseng dietary fiber.
Abstract translation: 目的：提供一种通过湿磨人参滤饼作为人参提取物残渣制备标题功能饮料的方法，用多糖酶或酸水解所得人参浆糊，然后混合所得人参膳食纤维和人参寡糖。 通过在饮料或发酵乳中添加人参膳食纤维和人参寡糖，可以获得功能性得到改善的发酵乳或饮料。 组成：将人参饼倒入一个间距为0.02-0.3mm的湿磨机中，研磨并将磨碎的人参块在121℃进行蒸煮灭菌10-30分钟。 此后，将获得的人参糊状物用纤维素酶，半纤维素和果胶酶单独或其酶的混合溶液以1：1至1：0.001的重量比在30至60℃下水解30分钟至6小时，或者用 在60至100℃下酸30分钟至4小时。 将水解样品进行离心分离并在室温下干燥，得到不溶性人参膳食纤维。 过滤离心分离后得到的上清液，加入异丙醇，用异丙醇和丙酮洗涤，得到可溶性人参膳食纤维。 加入异丙醇期间获得的上清液在真空下浓缩，得到可溶性人参寡糖，然后与先前获得的人参膳食纤维混合。
-
公开(公告)号：KR100379582B1
公开(公告)日：2003-04-08
申请号：KR1020000067244
申请日：2000-11-13
Applicant: 황재관
IPC: A23L1/10
Abstract: PURPOSE: The physiologically active substances isolated from grains and a producing method thereof are provided to easily and readily produce the physiologically active substances. CONSTITUTION: The physiologically active substances isolated from grains comprises the steps of: inserting grains into an extruder and extruding them under conditions: 200 to 400 rpm of screw speed, 20 to 50 kg/hour of grain inserting rate, 15 to 40% of humidity and 100 to 200 deg. C of heating temperature; adding hydrolases into the extrudates in a weight ratio of 1:0.0001 to 1:1 and reacting them at 30 to 60 deg. C for 5 to 24 hours; and drying the enzyme hydrolyzed grains in a drum dryer at 40 to 90 deg. C for 10 to 20 hours. Wherein, the grains are selected from the outer surfaces of rice, barely, wheat, corn, job's tear, buckwheat and rye, and the hydrolases are selected from cellulase, arabinase, mannase and glucanase.
Abstract translation: 目的：提供从谷物中分离的生理活性物质及其生产方法，以容易且容易地生产生理活性物质。 组成：从谷物中分离出的生理活性物质包括以下步骤：将谷物插入挤压机中并在螺杆速度为200至400rpm，谷粒插入率为20至50kg /小时，湿度为15至40％ 和100至200度。 加热温度C; 以1:0.0001至1:1的重量比将水解酶加入挤出物中，并在30至60℃下使它们反应。 C 5至24小时; 并在40至90℃下在滚筒式干燥器中干燥酶水解的谷物。 C 10至20小时。 其中，谷物选自米，勉强，小麦，玉米，工作眼泪，荞麦和黑麦的外表面，并且水解酶选自纤维素酶，阿拉伯酶，甘露聚糖酶和葡聚糖酶。
-
-
-
-
-
-
-
-
-
Search Results
59
records
(took 0.033 seconds)
