Abstract:
A lipid-based nano-carrier is provided to increase the whitening effect of an extract of Mori Cotex Radicis by encapsulating an extract of Mori Cortex Radicis in the lipid-based nano-carrier in which cholesteryl hemisuccinate is introduced, thereby effectively inhibiting the melanogenesis without side effects. The lipid-based nano-carrier is characterized in that it is in the form of a liposome dispersion or a nano-emulsion in which cholesteryl hemisuccinate encapsulating an extract of Mori Cortex Radicis or a salt thereof is introduced. Regarding the total weight of the total liposome dispersion or the nano-emulsion, the content of the lipid is 0.001-20 wt.% and the content of the extract is 0.001-30 wt.%. The skin whitening composition comprises the nano-carrier.
Abstract:
PURPOSE: Provided is a whitening composition for external applications to the skin containing D-fructose 1,6-diphosphate or derivatives thereof inhibiting the formation melanin and the decrease of glutathione formation. CONSTITUTION: A whitening composition for external applications to the skin is characterized by containing d-fructose 1,6-diphosphate or derivatives thereof in the amount of 0.0001-20 wt.%, based on the total weight of the composition for external applications to the skin.
Abstract:
본발명은캐드헤린11(Cadherin 11) 및 N-캐드헤린(N-cadherin) 중하나이상의발현억제물질을유효성분으로포함하는피부개선용조성물및 이를포함하는피부개선키트를제공함으로써피부과색소침착증을개선할수 있으며, 피부미백효과를제공할수 있다. 피부주름생성을방지또는완화할수 있으므로, 우수한항노화효과를제공한다. 또한, 본발명은섬유아세포(fibroblast), 각질형성세포(keratinocyte) 및멜라닌생성세포(melanocyte) 중 2종이상의공배양물을포함하는피부개선물질스크리닝시스템, 및상기피부개선물질스크리닝시스템의공배양물에후보물질을처리하는단계, 및캐드헤린11 및 N-캐드헤린중 하나이상의발현변화를측정하는단계를포함하는것을특징으로하는피부개선물질의스크리닝방법을제공함으로써, 생체외(in vitro)에서도임상적으로캐드헤린11, N-캐드헤린의발현변화를용이하게측정하여, 피부개선물질을효과적으로스크리닝할수 있다.
Abstract:
본 발명은 신경 통증감각 수용체(TRPV-1, VR1, Transient Receptor Potential family V-1)의 활성을 억제하는 단계를 포함하는 피부 미용방법, 피부 미용 물질 스크리닝(screening) 방법, 및 신경 통증감각 수용체의 활성을 억제하는 물질을 유효 성분으로 함유하는 피부 미용 조성물을 제공한다. 본 발명에 따르면, 신경 통증감각 수용체의 활성 억제를 통해 피부 미용을 증대시킬 수 있고, 피부 미용에 유효한 타겟 물질을 선정할 수 있으며, 선정된 물질은 신경 통증감각 수용체의 활성 억제로 인한 콜라겐 분해효소의 발현 감소, 피부 자극 완화, 및 혈행촉진을 유도할 수 있는 바, 피부 노화 방지 등을 통한 피부 미용에 특히 유효하다. 신경 통증감각 수용체, 피부 미용
Abstract:
The present invention relates to a method for screening a test substance having whitening efficacy and, more specifically, to a method for screening a test substance having whitening efficacy by checking whether or not the test substance activates Forkhead box O3A (FoxO3a) or promotes the expression thereof using FoxO3a which is a longevity gene, and thereby determining whether or not the test substance has whitening efficacy.
Abstract:
Disclosed are: a skin whitening agent containing a liver X receptor agonist as an effective component; and a screening method of a skin whitening material including a step of checking the promotion degree of liver X receptor expression or activation of cells by a candidate substance. [Reference numerals] (AA,BB) Amount of melanin(%)