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公开(公告)号：KR101836475B1
公开(公告)日：2018-03-08
申请号：KR1020160098658
申请日：2016-08-02
Applicant: 아주대학교산학협력단
Abstract: 본발명은태아연골조직유래세포및 태아연골조직유래세포외기질을포함하는연골재생용조성물, 이의제조방법에관한것이다. 본발명에따른연골재생용조성물은인공지지체없이연골로사용에적합한크기의 3차원조직을제작할수 있으며, 조성물이젤 형태로투여가능하면서도높은도포성과부착성을가지고있기때문에투여부위의연골결손의크기및 모양에관계없이쉽게이식이가능하며, 숙주조직과의높은결합능을보이면서성숙한연골조직의표현형을가짐으로써연골재생효능이뛰어난효과를보인다.
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公开(公告)号：KR1020180015041A
公开(公告)日：2018-02-12
申请号：KR1020160098658
申请日：2016-08-02
Applicant: 아주대학교산학협력단
CPC classification number: A61K35/32 , A61L27/36 , A61L27/3633 , A61L2430/06 , C12N5/0655
Abstract: 본발명은태아연골조직유래세포및 태아연골조직유래세포외기질을포함하는연골재생용조성물, 이의제조방법에관한것이다. 본발명에따른연골재생용조성물은인공지지체없이연골로사용에적합한크기의 3차원조직을제작할수 있으며, 조성물이젤 형태로투여가능하면서도높은도포성과부착성을가지고있기때문에투여부위의연골결손의크기및 모양에관계없이쉽게이식이가능하며, 숙주조직과의높은결합능을보이면서성숙한연골조직의표현형을가짐으로써연골재생효능이뛰어난효과를보인다.
Abstract translation: 软骨再生用组合物及其制造方法技术领域本发明涉及软骨再生用组合物及其制造方法，该软骨再生用组合物含有胎儿软骨组织来源的细胞和来源于胎儿软骨组织的细胞外基质。 根据本发明的软骨修复的组合物可以产生适合用作无支架的软骨的大小的三维纹理和组合物画架形式的给药是可能的，但高的涂层和粘合剂具有因软骨的注射部位缺陷的大小 并且可以容易地移植而不管形状，并且对宿主组织具有高结合能力，并且具有成熟软骨组织的表型，由此表现出软骨再生的效果。
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公开(公告)号：KR101718669B1
公开(公告)日：2017-03-21
申请号：KR1020160172696
申请日：2016-12-16
Applicant: 아주대학교산학협력단
IPC: A61L27/36
Abstract: 본발명은태아연골조직유래세포및 태아연골조직유래세포외기질(extracellular matrix)를유효성분으로포함하고, 젤형태(gel type)인인공연골및 상기인공연골을유효성분으로함유하는연골결손치료용조성물에대한것으로, 특히본 발명에서개시하는인공연골조직은인위적인지지체를사용하지않고도직경 5mm 이상의큰 크기의 3차원조직을제작할수 있으며, 성숙한연골조직의표현형을가지면서도물리적특성이딱딱하지않고유연성과탄성을가지고있기때문에연골결손의크기와모양에관계없이쉽게이식이가능하며숙주조직과의결합력이우수하여연골재생효능이뛰어난장점을가지고있다.
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公开(公告)号：KR101633585B1
公开(公告)日：2016-06-27
申请号：KR1020150044204
申请日：2015-03-30
Applicant: 아주대학교산학협력단
IPC: A61K35/32 , A61K35/12 , A61K31/198 , A61K9/70
Abstract: 본발명은표면개질된연골세포유래세포외기질막을유효성분으로함유하는유착방지용조성물에대한것으로, in vitro에서연골유래세포외기질소재에대한섬유세포의부착효율이낮고, 마우스를이용한피하유착동물모델및 랫을이용한장유착모델에서우수한유착방지효능을보임을관찰하였다. 또한폴리-L-리신(poly-L-lysine; PLL)을이용하여본 소재의표면전하를중성으로개질할경우유착방지효과가현저히증가함을확인함으로써, 연골세포유래세포외기질소재를이용하여체내안정성과유착방지효능이뛰어난유착방지제로활용할수 있다.
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公开(公告)号：KR101471646B1
公开(公告)日：2014-12-26
申请号：KR1020120091184
申请日：2012-08-21
Applicant: 인하대학교 산학협력단 , 아주대학교산학협력단
Abstract: 본발명은같은환자에대하여서로다른시간에획득한의료영상으로부터질환을모니터링하기위해필요한의료영상의정합기법에관한것으로, 본발명에따르면, 종래의분할기반의기법과화소값기반기법의장점을취합하여, 3차원의료영상데이터를보다빠르고정확하게처리할수 있도록, GP-GPU 기반병렬처리를적용하는것을특징으로하는 GP-GPU를이용한 3D 의료영상정합의병렬처리방법이제공된다.
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Patent Agency Ranking
公开(公告)号：KR1020140031813A
公开(公告)日：2014-03-13
申请号：KR1020130106091
申请日：2013-09-04
Applicant: 아주대학교산학협력단
Abstract: The present invention relates to a composition for preventing or treating immune disease comprising human fetal cartilage-derived cells which can control and adjust an immune reaction generated from tissue transplantation. More specifically, the human fetal cartilage-derived cells do not cause immune reaction, control proliferation of activated lymphocytes, control the expression of cytokines in an immune system generated from the activated lymphocytes, and have remarkable proliferation ability and differentiation potential to various cell tissues compared to adult stem cells, thereby being practically used as an immunomodulator for controlling the immune reaction which can be caused from the regeneration of damaged tissues and the tissue transplantation.
Abstract translation: 本发明涉及用于预防或治疗免疫疾病的组合物，其包含可以控制和调节由组织移植产生的免疫反应的人胎儿软骨来源的细胞。 更具体地说，人胎儿软骨来源的细胞不会引起免疫反应，控制活化淋巴细胞的增殖，控制由活化淋巴细胞产生的免疫系统中的细胞因子的表达，并且对各种细胞组织具有显着的增殖能力和分化潜力 成为干细胞，从而实际上被用作免疫调节剂，用于控制由受损组织的再生和组织移植引起的免疫反应。
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公开(公告)号：KR1020130043921A
公开(公告)日：2013-05-02
申请号：KR1020110108110
申请日：2011-10-21
Applicant: 아주대학교산학협력단
CPC classification number: C12M23/04 , C12M23/20 , C12N5/0655 , C12N5/0662
Abstract: PURPOSE: A cell culture substrate of a fine structure is provided to control the growth and differentiation of a cell, and to overcome a dedifferentiation phenomenon of chondrocyte cultivation through a special structure design of the culture substrate. CONSTITUTION: A cell culture substrate comprises a thin film in which fine particles are arranged. The surface characteristics of the cell culture substrate obtained with the arrangement of the spherical fine particles satisfy the following: surface roughness(Rq)
Abstract translation: 目的：提供细胞结构的细胞培养底物，以控制细胞的生长和分化，并通过培养基质的特殊结构设计克服软骨细胞培养的去分化现象。 构成：细胞培养基材包括其中布置细颗粒的薄膜。 通过配置球状微粒而获得的细胞培养基的表面特性满足以下：表面粗糙度（Rq）<= 0.13D（细颗粒的平均粒径）。 细颗粒的平均粒径在250纳米-10微米的范围内。 细颗粒的平均粒径在300纳米-3微米的范围内。 表面粗糙度为25纳米-1000纳米，表面高差为170纳米-10微米。
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公开(公告)号：KR1020100041027A
公开(公告)日：2010-04-22
申请号：KR1020080100005
申请日：2008-10-13
Applicant: 아주대학교산학협력단
CPC classification number: A61F2/00 , A61L27/3604 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3852 , A61L27/56 , A61L2400/08 , A61L2400/18 , A61L2430/06 , A61L2430/40
Abstract: PURPOSE: A method for preparing three-dimensional scaffold and a three-dimensional scaffold manufactured by the same method are provided, which improves regeneration effect of the hyaline cartilage organization. CONSTITUTION: A method for preparing three-dimensional scaffold comprises: a step of pulverizing tissue from animals; a decellularization step of performing decellularization before or after pulverization of tissue from animals, or at the same time; and a step of forming the powder of decellularized tissue from animals into a porous 3D supporter using a particle distillation method.
Abstract translation: 目的：提供一种通过相同方法制备三维支架和三维支架的方法，从而提高透明软骨组织的再生效果。 构成：制备三维支架的方法包括：从动物粉碎组织的步骤; 在从动物组织粉碎之前或之后或同时进行脱细胞化的脱细胞化步骤; 以及使用粒子蒸馏法将动物的脱细胞组织粉末形成多孔3D支架的步骤。
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公开(公告)号：KR102250064B1
公开(公告)日：2021-05-07
申请号：KR1020180138022
申请日：2018-11-12
Applicant: 아주대학교산학협력단
Abstract: 본발명은동물연골유래조직을가교화하여제조된하이드로젤및 이의제조방법에관한것이다. 본발명에따른생체적합성동물연골유래조직하이드로젤은가교제의함량등에따라생화학적가교에의해생분해기간을지연시킬수 있고, 기계적인물성을증가시킬수 있으며, 가교결합의형성정도에따라생분해기간및 기계적인물성을조절할수 있다는장점이있다. 또한, 본발명에따른동물연골유래조직하이드로젤은주사형제제로이용되어, 조직수복, 약물전달또는세포전달등을위해사용될수 있는특징이있다.
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