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公开(公告)号：KR1020130094532A
公开(公告)日：2013-08-26
申请号：KR1020120015863
申请日：2012-02-16
Applicant: 조선대학교산학협력단
IPC: C07K14/005 , C07K19/00 , C12N7/01 , A01N63/00
Abstract: PURPOSE: A HPA3NT3-Chaetoceros salsugineum nuclear inclusion virus (CsNIV) capsid complex is provided to compensate for a weakness that water-soluble HPA3NT3 peptides are easily dissolved in sea water, thereby obtaining an anti-red tidal agent which is safe and useful in a marine eco-system. CONSTITUTION: A HPA3NT3-CsNIV capsid complex with an anti-red tide activity is prepared by loading an HPA3NT3 peptide with an amino acid sequence of sequence number 3 in CsNIV capsid. The HPA3NT3 peptide has an HPA3 peptide sequence of sequence number 2, in which 9th amino acid (Glu) and 13th amino acid (Ser) are substituted with lysine (Lys). The CsNIV capsid has an amino acid sequence of sequence number 4 or 5. [Reference numerals] (AA,BB) Assemble
Abstract translation: 目的：提供HPA3NT3-Chaetoceros salsugineum核包涵病毒（CsNIV）衣壳复合物，以补偿水溶性HPA3NT3肽容易溶解在海水中的弱点，从而获得安全有效的抗红潮潮药 海洋生态系统。 构成：通过在CsNIV衣壳中加载具有序列号3的氨基酸序列的HPA3NT3肽来制备具有抗赤潮活性的HPA3NT3-CsNIV衣壳复合物。 HPA3NT3肽具有序列号2的HPA3肽序列，其中第9个氨基酸（Glu）和第13个氨基酸（Ser）被赖氨酸（Lys）取代。 CsNIV衣壳具有序列号4或5的氨基酸序列。（附图标记）（AA，BB）组装
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公开(公告)号：KR101263452B1
公开(公告)日：2013-05-10
申请号：KR1020110053429
申请日：2011-06-02
Applicant: 조선대학교산학협력단
IPC: C07K14/435 , A61K38/17 , A61K8/64 , A61P31/04
CPC classification number: Y02A50/473
Abstract: 본발명은키조개(Korean pen shell,)에서추출한신규한열 안정성펩타이드에관한것으로, 보다구체적으로본 발명의키조개에서추출한신규한열 안정성펩타이드는그람음성균에대한강력한항균활성을나타내고독성이없으므로본 발명의펩타이드를유효성분으로함유하는항균제, 화장품보존제, 의약품보존제및 생물농약으로유용하게사용될수 있다.
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公开(公告)号：KR101249771B1
公开(公告)日：2013-04-01
申请号：KR1020100080018
申请日：2010-08-18
Applicant: 조선대학교산학협력단
Abstract: 본 발명은 생물체 유래의 천연 항적조 펩타이드에 관한 것으로서, 보다 구체적으로 본 발명에 따른 HPA3NT3 펩타이드는 탁월한 항적조 활성을 나타내며, 이러한 항적조 활성은 적조유발 생물에만 선택적으로 나타나며, 자연 분해가 가능하며, 세포 독성이 없으므로 해양 생태계에 안전하고 유용한 항적조제로써 사용될 수 있다.
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公开(公告)号：KR1020120021826A
公开(公告)日：2012-03-09
申请号：KR1020100080012
申请日：2010-08-18
Applicant: 조선대학교산학협력단
IPC: C07K7/08 , C07K14/435 , A01N63/02
Abstract: PURPOSE: An anti-red tide peptide P5 with anti-red tidal activity is provided to ensure excellent red tidal activity without toxicity. CONSTITUTION: A P5 peptide has an amino acid sequence of sequence number 2. The P5 peptide is a peptide or derivative with enhanced positive charge and hydrophobic region by substituting one or more amino acids of CA-MA(crecropinA-magainin 2) peptide of sequence number 1. The P5 peptide has an anti-red tidal activity to C. polykrikoides, C. marina, or H. akashiwo. An anti-red tidal composition contains P5 peptides as an active ingredient.
Abstract translation: 目的：提供抗红潮汐活性的抗红潮肽P5，以确保无毒性的极好的红潮活性。 构成：P5肽具有序列号2的氨基酸序列.P5肽是具有增强的正电荷和疏水区域的肽或衍生物，其通过用序列的CA-MA（crecropinA-magainin 2）肽取代一个或多个氨基酸 P5肽对C. polykrikoides，C. marina或H. akashiwo具有抗红潮汐活动。 抗红潮组合物含有P5肽作为活性成分。
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公开(公告)号：KR101077180B1
公开(公告)日：2011-10-27
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: 본발명은헬리코박터파일로리균()의리보좀단백질 L1(ribosomal protein L1, RPL1) 유래의새로운항생펩타이드및 그의용도에관한것으로, 구체적으로헬리코박터파일로리균의리보좀단백질 L1 유래의서열번호 1로기재되는아미노산서열을가지는항생펩타이드로부터 1번과 8번위치의페닐아라닌을알라닌으로치환하거나, 이에추가적으로 13번위치의아스파라긴을리신으로치환함으로써제조된펩타이드들은기존의항생펩타이드에비해세포독성은낮게유지하면서항균활성은더 높게나타냄으로써인체에안전한항생제로유용하게사용될수 있다.
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Patent Agency Ranking36.发明公开
公开(公告)号：KR1020100058794A
公开(公告)日：2010-06-04
申请号：KR1020080117335
申请日：2008-11-25
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A ribosomal protein L1(RPL1)-derived novel antibiotics peptide of helicobacter pylori is provided to ensure high antibacterial activity to gram positive bacterial and gram negative bacteria. CONSTITUTION: An antibiotics peptide with reduced citotoxicity is obtained by substituting phenylalanine of site 1 and 8 in an antibiotics peptide of sequence number 1 with alanine. The antibiotics peptide is denoted by sequence number 2. An antibiotics having antibacterial activity to gram-positive bacteria or gram-negative bacteria contains the antibiotics peptide as an active ingredient. A food additive or food supplement contains the antibiotic peptide as an active ingredient.
Abstract translation: 目的：提供核糖体蛋白L1（RPL1）衍生自幽门螺杆菌的新型抗生素肽，以确保革兰氏阳性细菌和革兰氏阴性菌的高抗菌活性。 构成：通过用1号丙氨酸取代序列号1的抗生素肽中的位点1和8的苯丙氨酸来获得具有降低的宿性毒性的抗生素肽。 抗生素肽由序列号2表示。对革兰氏阳性菌或革兰氏阴性菌具有抗菌活性的抗生素含有抗生素肽作为活性成分。 食品添加剂或食品添加剂含有抗生素肽作为活性成分。
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37.发明公开고구밸리 감자에서 추출된 단백질 추출물 또는 펩타이드를함유하는 항암용 약학조성물 有权用于包含来自Solanum TUBEROSUM L CV的提取的蛋白质或肽的抗体的药物组合物。 GOGU VALLEY
公开(公告)号：KR1020090113526A
公开(公告)日：2009-11-02
申请号：KR1020080039285
申请日：2008-04-28
Applicant: 주식회사 메디트론바이오 , 강원대학교산학협력단 , 조선대학교산학협력단
CPC classification number: A61K36/81 , A61K38/011
Abstract: PURPOSE: A pharmaceutical composition for anti-cancer containing protein extract isolated from Solanum tuberosum L., cv. Gogu valley or peptide isolated from the protein extract is provided to ensure function of suppressing skin cancer and gastric cancer. CONSTITUTION: A pharmaceutical composition for anticancer contains protein extract isolated from Solanum tuberosum L., cv. Gogu valley. The cancer is skin cancer or gastric cancer. The protein extract is used in the form of liquid, tablet, granule, capsule, suspension, syrup, ointment or injection.
Abstract translation: 目的：从马铃薯（Solanum tuberosum L.）分离的含有蛋白质提取物的抗癌药物组合物， 提供从蛋白质提取物分离的Gogu谷或肽，以确保抑制皮肤癌和胃癌的功能。 构成：用于抗癌的药物组合物含有从马铃薯（Solanum tuberosum L.），cv。 戈古谷 癌症是皮肤癌或胃癌。 蛋白质提取物以液体，片剂，颗粒，胶囊，悬浮液，糖浆，软膏或注射剂的形式使用。
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38.发明公开헬리코박터 파일로리균의 리보좀 단백질 Ｌ１유래의 새로운접힘 구조를 갖는 항생 펩타이드 및 조성물 有权HELICOBACTER PYLORI的RIBOSOMAL蛋白L1衍生的新型合成抗微生物蛋白肽及其组成
公开(公告)号：KR1020090002435A
公开(公告)日：2009-01-09
申请号：KR1020070064230
申请日：2007-06-28
Applicant: 조선대학교산학협력단
Abstract: An antibiotic peptide, and a composition containing the antibacterial peptide are provided to improve antibacterial and fungicidal effects and to remove cytotoxicity. An antibiotic peptide has the folding structure by replacing the glutamic acid of the 9th amino acid of the peptide HPA3 having the amino acid sequence represented by the sequence number 2 with proline, and has the sequence represented by the sequence number 3. Preferably the hydrophobic and flexible regions of the antibiotic peptide is increased compared with the peptide having the amino acid sequence represented by the sequence number 2.
Abstract translation: 提供抗生素肽和含有抗菌肽的组合物以提高抗细菌和杀真菌作用并去除细胞毒性。 通过用脯氨酸替代具有序列号2所示的氨基酸序列的肽HPA3的第9个氨基酸的谷氨酸，抗生素肽具有折叠结构，并且具有由序列号3表示的序列。优选地，疏水和 与具有由序列号2表示的氨基酸序列的肽相比，抗生素肽的柔性区域增加。
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公开(公告)号：KR102173815B1
公开(公告)日：2020-11-03
申请号：KR20190037878
申请日：2019-04-01
Applicant: 조선대학교산학협력단 , 이승규 , 이사홍
IPC: B01L9/00
Abstract: 본발명은피펫팁을팁보관함에용이하게꽂을수 있도록돕는피펫팁 꽂이어시스트장치에관한것이다. 본발명에따른피펫팁 꽂이어시스트장치는복수의피펫팁이일방향을따라이동할수 있도록상호나란하게연장되어있는복수의가이드홈이상하방향을따라인입되어형성되고, 상기가이드홈의단부에형성되고상기피펫팁이하방으로토출될수 있도록상기피펫팁이통과할수 있는직경을가지며상하방향으로관통된팁토출구가형성된메인바디와, 상기메인바디에형성되며, 상기가이드홈에끼워진피펫팁을상기팁토출구측으로이동시키기위한팁이송부와, 상기메인바디에형성되고, 상기팁토출구측으로이송된피펫팁이팁토출구를통해토출되는것을허용하거나차단하기위한토출개폐부를포함한다.
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公开(公告)号：KR101998106B1
公开(公告)日：2019-07-09
申请号：KR1020170122504
申请日：2017-09-22
Applicant: 조선대학교산학협력단
IPC: C07K7/08 , A23K20/147 , A23K20/195 , A23L3/3463 , A61K8/64 , A61Q19/00 , A61K38/00 , A01N33/08
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