Abstract:
본 발명은 Rheb(Ras homolog enriched in the brain) 및 튜불린(tubulin)의 상호작용에 의한 Rheb에 결합하는 뉴클레오티드의 조절 및 상기 조절을 통한 mTOR 활성과의 관계를 밝혀낸 연구 결과에 기초한 것으로, 구체적으로는 튜불린(tubulin)의 중합 또는 아세틸화 조절제를 유효성분으로 포함하여 Rheb(Ras homolog enriched in the brain)-GTP 복합체의 세포내 수준을 조절하는 것인 mTOR 활성 조절제 및 상기 활성 조절제의 검출 방법에 관한 것이다.
Abstract:
PURPOSE: A composition containing a water extract of Fomitella fraxinea(Fr.)Imaz. is provided to suppress absorption of neutral fat and cholesterol, and to prevent or treat obesity. CONSTITUTION: A composition for preventing or treating obesity contains a water extract of Fomitella fraxinea(Fr.)Imaz. as an active ingredient. Health functional food for preventing or treating obesity contains the water extract as an active ingredient. The health functional food is food, a food additive, or a drink. The health functional food and the water extract suppress the activity of lipase and/or pancreatic cholesterol esterase. [Reference numerals] (AA) TGL activity inhibition(%); (BB) Water extract; (CC) (Comparative example) Ethanol extract
Abstract:
PURPOSE: A composition containing an alcohol extract of Hapalopilus rutilans is provided to suppress digestion and absorption of body fat, and to prevent or treat obesity. CONSTITUTION: A composition for preventing or treating obesity contains a C1-C10 alcohol extract of Hapalopilus rutilans as an active ingredient. The extract is prepared by extracting Hapalopilus rutilans with 90-99.9%(v/v) ethanol at 20-60 deg. C for 12-36 hours. A pharmaceutical product for preventing or treating obesity contains the extract as an active ingredient. A health functional food for preventing or treating obesity contains the extract as an active ingredient. A method for preventing or treating obesity comprises a step of administering the extract to animals exclusive of human. The extract suppresses activation of pancreatic lipase. [Reference numerals] (AA) TGL activity inhibition(%); (BB) Water extract (Comparative example); (CC) Ethanol extract