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    지혈효과 및 기계적 물성이 우수한 지능형 피브린 생체접착제
    31.
    发明公开
    지혈효과 및 기계적 물성이 우수한 지능형 피브린 생체접착제 无效
    智能纤维生物降解与超声爆破和机械性能

    公开(公告)号：KR1020110023399A

    公开(公告)日：2011-03-08

    申请号：KR1020090081256

    申请日：2009-08-31

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  박귀덕 ,  김재진 ,  박철호

    IPC: A61L24/10 ,  A61L24/08 ,  A61L24/04 ,  A61L33/12 ,  A61L24/00

    CPC classification number: A61L24/106 ,  A61L24/0015 ,  A61L24/04 ,  A61L24/08 ,  A61L33/126

    Abstract: PURPOSE: An intelligent fibrin bio-adhesive with superior hemostasis effect and mechanical properties is provided to obtain an anti-bacteria property by adding natural polymer and/or antibiotics. CONSTITUTION: Fibrin and natural polymer form crosslinkage, and interpenetrating network or semi-interpenetrating network is obtained. The natural polymer is one or more selected from a group including alginate, chitosan, chitin, cellulose, agarose, amylase, dextran, proteoglycan, glycosaminoglycan, collagen, gelatin, heparin, hyaluronic acid, pectin, carrageena, chondroitin sulfate, dextran sulfate, polylysine, pullulan, carboxylmethyl chitin, and the salt of the same. Antibiotics are additionally introduced into the interpenetrating network or the semi-interpenetrating network.

    Abstract translation: 目的：提供具有优异止血效果和机械性能的智能纤维蛋白生物粘合剂，通过加入天然聚合物和/或抗生素获得抗细菌性能。 构成：纤维蛋白和天然聚合物形成交联，获得互穿网络或半互穿网络。 天然聚合物是选自藻酸盐，壳聚糖，壳多糖，纤维素，琼脂糖，淀粉酶，葡聚糖，蛋白聚糖，糖胺聚糖，胶原，明胶，肝素，透明质酸，果胶，角叉菜胶，硫酸软骨素，硫酸葡聚糖，聚赖氨酸 ，支链淀粉，羧甲基甲壳质及其盐。 抗生素还被引入到互穿网络或半互穿网络中。

    나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트
    32.
    发明公开
    나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트 有权
    用于制备具有纳米结构图的药物治疗手段的方法及其制备的药物治疗

    公开(公告)号：KR1020100077770A

    公开(公告)日：2010-07-08

    申请号：KR1020080135808

    申请日：2008-12-29

    Applicant: 한국과학기술연구원

    Inventor： 문명운 ,  이광렬 ,  한동근 ,  박귀덕

    IPC: A61L31/10 ,  A61L31/16 ,  A61F2/82 ,  A61L27/34 ,  A61L27/54 ,  C08L67/04

    CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L2300/61 ,  A61L2400/12 ,  A61L2400/18 ,  A61F2/82 ,  A61L27/34 ,  A61L27/54 ,  C08L67/04

    Abstract: PURPOSE: A method of manufacturing a medical stent for releasing medical drugs and a medical stent for releasing medical drugs using the same method are provided, which have the nano-structured pattern using the plasma-assisted chemical vapor deposition. CONSTITUTION: A method of manufacturing medical stent for releasing medical drug having the nano-structured pattern includes: a step of coating the surface of stent with the biodegradable polymer; a step of forming the nano-structured pattern on the surface of the stent coated with the biodegradable polymer through the ion beam or the plasma process using the method of plasma-assisted chemical vapor deposition; and a step of dipping the medical drugs within the biodegradable polymer in which the nano-structured pattern is formed. The biodegradable polymer is the biodegradable polymer in which the medical drugs are dipped.

    Abstract translation: 目的：提供一种使用等离子体辅助化学气相沉积制造具有纳米结构图案的用于使用相同方法制造用于释放药物的医用支架和用于释放药物的药物支架的方法。 构成：制造具有纳米结构图案的医药用医用支架的方法，其特征在于，包括以下步骤：用生物降解性聚合物涂布支架表面; 使用等离子体辅助化学气相沉积的方法通过离子束或等离子体处理在涂覆有可生物降解的聚合物的支架的表面上形成纳米结构图案的步骤; 以及将药物浸渍在其中形成纳米结构图案的生物可降解聚合物中的步骤。 可生物降解的聚合物是医用药物浸渍的可生物降解的聚合物。

    하이드록시아파타이트를 함유한 조직공학용 다공성 생분해고분자 지지체 및 이의 제조방법
    33.
    发明授权
    하이드록시아파타이트를 함유한 조직공학용 다공성 생분해고분자 지지체 및 이의 제조방법 有权
    含有组氨酸工程的羟基磷酸酯的可生物降解多孔聚合物的制备方法

    公开(公告)号：KR100794174B1

    公开(公告)日：2008-01-14

    申请号：KR1020060113227

    申请日：2006-11-16

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  박귀덕 ,  손준식 ,  정현정

    IPC: C08J9/00 ,  C08J7/00 ,  A61L31/00

    Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.

    Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。

    설포베타인 폴리에틸렌글리콜 유도체로 표면개질된혈액적합성 금속재료 및 이의 제조방법
    34.
    发明授权
    설포베타인 폴리에틸렌글리콜 유도체로 표면개질된혈액적합성 금속재료 및 이의 제조방법 失效
    설포베타인폴리에틸렌글리콜유도체로표면개질된혈액적합성속속료및이의제조방

    公开(公告)号：KR100752100B1

    公开(公告)日：2007-08-27

    申请号：KR1020060104844

    申请日：2006-10-27

    Applicant: 한국과학기술연구원

    Inventor： 한동근 ,  김재진 ,  박귀덕 ,  김재훈

    IPC: C23C22/28 ,  C08J7/04 ,  A61L27/04 ,  A61F2/82

    Abstract: A cardiovascular system transplanting metallic material is provided to improve blood compatibility by modifying the surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative having anions. A metallic material has improved blood compatibility by modifying a surface of the metallic material with a sulfobetaine poly(ethylene glycol) derivative of the formula 1, X-R1-PEG-R1-Y, where R1 is one or more functional groups connected by urethane, urea, amide, ester, ether or anhydride comprising 0 to 20 alkyl groups or aryl groups; X is -NCO or -CHO; and Y is sulfobetaine(-N^+ -R2 -SO3^-) as a zwitterionic derivative, wherein R2 is an alkyl group or an aryl group. A manufacturing method of a metallic material of which surface is modified with a sulfobetaine poly(ethylene glycol) derivative comprises the steps of: oxidizing the surface of the metallic material to introduce a hydroxyl group(-OH) into the surface thereof; and chemically bonding the sulfobetaine poly(ethylene glycol) derivative to the hydroxyl group of the metallic material surface.

    Abstract translation: 提供心血管系统移植金属材料以通过用具有阴离子的磺基甜菜碱聚（乙二醇）衍生物修饰金属材料的表面来改善血液相容性。 金属材料通过用式1的磺基甜菜碱聚（乙二醇）衍生物X-R1-PEG-R1-Y对金属材料的表面进行改性来改善血液相容性，其中R1是通过氨基甲酸酯连接的一个或多个官能团 ，包含0至20个烷基或芳基的脲，酰胺，酯，醚或酸酐; X是-NCO或-CHO; 并且Y是磺基甜菜碱（-N ^ + -R 2 -SO 3 - ） - 作为两性离子衍生物，其中R 2是烷基或芳基。 其表面用磺基甜菜碱聚（乙二醇）衍生物改性的金属材料的制造方法包括以下步骤：氧化金属材料的表面以将羟基（-OH）引入其表面; 并将磺基甜菜碱聚（乙二醇）衍生物化学结合到金属材料表面的羟基上。

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