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Patent Agency Ranking
公开(公告)号：KR1020090131975A
公开(公告)日：2009-12-30
申请号：KR1020080058006
申请日：2008-06-19
Applicant: 한국과학기술연구원
CPC classification number: A61K9/1647 , A61K9/1694 , A61K38/00
Abstract: PURPOSE: A method for preparing biodegradable covered porous polymer microspheres is provided to control a pore size of microspheres, and to prepare porous polymer microspheres capable of ensuring sustained release control and persistence of a sealed drug. CONSTITUTION: A method for preparing biodegradable covered porous polymer microspheres comprises the steps of: dissolving or suspending a bio-active material in a polymer solution that a biodegradable polymer is dissolved in an organic solvent to prepare a polymer solution containing a bio-active material; adding a hydrogen peroxide-containing compound to the polymer solution and mixing the mixture to prepare water-in-oil type emulsion; emulsifying the water-in-oil type emulsion in a emulsion stabilizer solution to prepare oil-in-water type emulsion; and adding a hydrogen peroxide decomposition catalyst to the oil-in-water type emulsion to degrade hydrogen peroxide and evaporate organic solvent.
Abstract translation: 目的：提供一种制备可生物降解的覆盖多孔聚合物微球的方法，以控制微球的孔径，并制备能够确保密封药物的持续释放控制和持久性的多孔聚合物微球。 构成：制备可生物降解的覆盖多孔聚合物微球的方法包括以下步骤：将生物活性物质溶解或悬浮在可生物降解聚合物溶于有机溶剂中的聚合物溶液中以制备含有生物活性物质的聚合物溶液; 向聚合物溶液中加入含过氧化氢的化合物，混合该混合物以制备油包水型乳液; 将油包水型乳液乳化在乳化稳定剂溶液中以制备水包油型乳液; 并向水包油型乳液中加入过氧化氢分解催化剂以降解过氧化氢并蒸发有机溶剂。
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公开(公告)号：KR100786648B1
公开(公告)日：2007-12-21
申请号：KR1020060104859
申请日：2006-10-27
Applicant: 한국과학기술연구원
Abstract: A photopolymerizable composite material composition for dental service and orthopedics is provided to improve physical properties, mechanical properties and biocompatibility. A photopolymerizable composite material composition comprises 5-95 wt% of an organic matrix component; and 5-95 wt% of an inorganic filler. The organic matrix component comprises 15-80 wt% of a multifunctional methacrylate prepolymer selected from a bifunctional methacrylate prepolymer represented by the formula 2, a trifunctional methacrylate prepolymer represented by the formula 3, a tetrafunctional methacrylate prepolymer represented by the formula 4 and their mixture; 5-50 wt% of a diluent; 1-40 wt% of a polymerization monomer; 0.1-10 wt% of a photoinitiator; and 0.1-10 wt% of other additives, wherein n is a number of 0-2; and R is H, CH3, CH2CH3 or -C(CH3)3.
Abstract translation: 提供用于牙科服务和骨科的可光聚合复合材料组合物以改善物理性能，机械性能和生物相容性。 可光聚合复合材料组合物包含5-95重量％的有机基质组分; 和5-95重量％的无机填料。 有机基质组分包含15-80重量％的选自由式2表示的双官能甲基丙烯酸酯预聚物，由式3表示的三官能甲基丙烯酸酯预聚物，由式4表示的四官能甲基丙烯酸酯预聚物及其混合物的多官能甲基丙烯酸酯预聚物; 5-50重量％的稀释剂; 1-40重量％的聚合单体; 0.1-10重量％的光引发剂; 和0.1-10重量％的其它添加剂，其中n为0-2的数; 且R为H，CH 3，CH 2 CH 3或-C（CH 3）3。
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公开(公告)号：KR100760511B1
公开(公告)日：2007-10-04
申请号：KR1020060113167
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold is provided to produce a biodegradable porous polymer scaffold for tissue engineering, which has no phenomena for pore clogging and harmful substances excretion and remain, and has an open structure with higher surface area and porosity. A method for preparing a biodegradable porous polymer scaffold for tissue engineering comprises the steps of: (a) adding a hydrogen peroxide-containing compound to a polymer solution which is obtained by dissolving a biodegradable polymer into a solvent, and mixing the resulting solution homogeneously; (b) allowing the solution obtained in the step (a) to stand at a temperature of -196 deg.C to a normal temperature so as to evaporate the solvent; and (c) introducing the polymer specimen obtained in the step (b) into an aqueous solution containing a catalyst for decomposition of hydrogen peroxide and foaming the resultant, followed by drying.
Abstract translation: 提供了一种制备可生物降解的多孔聚合物支架的方法，以生产组织工程的生物可降解多孔聚合物支架，其不存在孔堵塞和有害物质排泄现象，并具有较高表面积和孔隙率的开放结构。 制备用于组织工程的可生物降解的多孔聚合物支架的方法包括以下步骤：（a）向通过将可生物降解的聚合物溶解到溶剂中而获得的聚合物溶液中加入含过氧化氢的化合物，并均匀混合所得溶液; （b）使步骤（a）中得到的溶液在-196℃的温度下放置在常温下使溶剂蒸发; 和（c）将步骤（b）中获得的聚合物样品引入含有用于分解过氧化氢的催化剂的水溶液中并使所得物发泡，然后干燥。
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公开(公告)号：KR100794174B1
公开(公告)日：2008-01-14
申请号：KR1020060113227
申请日：2006-11-16
Applicant: 한국과학기술연구원
Abstract: A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface is provided to produce the biodegradable porous polymer scaffolds having improved cell affinity and osteoconductivity in a simple and effective manner. A method for preparing a biodegradable porous polymer scaffold having hydroxyapatite on the surface includes the steps of: (1) graft-polymerizing a functional group-containing hydrophilic monomer on the surface of a biodegradable porous polymer scaffold; and (2) immersing the obtained functional group-containing polymer scaffold in a simulated body fluid solution to form hydroxyapatite on the surface of the scaffold. The functional group-containing hydrophilic monomer is selected from the group consisting of organic acids having carboxylic acids at the terminals, monomers having phosphoric acids at the terminals, and mixtures thereof.
Abstract translation: 提供了一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法，以简单且有效的方式制备具有改善的细胞亲和力和骨传导性的可生物降解的多孔聚合物支架。 一种在表面上制备具有羟基磷灰石的可生物降解的多孔聚合物支架的方法包括以下步骤：（1）在可生物降解的多孔聚合物支架的表面上接枝聚合含官能团的亲水单体; 和（2）将获得的含官能团的聚合物支架浸入模拟的体液溶液中以在支架的表面上形成羟基磷灰石。 含官能团的亲水性单体选自末端具有羧酸的有机酸，末端具有磷酸的单体及其混合物。
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公开(公告)号：KR100963435B1
公开(公告)日：2010-06-17
申请号：KR1020080058006
申请日：2008-06-19
Applicant: 한국과학기술연구원
CPC classification number: A61K9/1647 , A61K9/1694 , A61K38/00
Abstract: 본 발명은 내부에는 넓은 표면적과 높은 다공도를 갖는 열린(open) 기공 구조를 갖고 외부 표면은 생분해성 고분자 박막(thin membrane)으로 덮여(covered) 기공의 개구부가 막힌 구조를 갖는 서방형 약물전달 및 조직재생용 덮인 다공성 생분해성 고분자 미립구(microsphere) 및 이의 제조방법에 관한 것으로, 구체적으로 본 발명에 따른 덮인 다공성 생분해성 고분자 미립구는 1) 생분해성 고분자를 유기용매에 용해시켜 고분자 용액을 제조하는 단계; 2) 과산화수소-함유 화합물을 상기 고분자 용액에 첨가한 후, 생리활성물질을 첨가하고 균일하게 혼합하여 유중수형(water in oil, W/O) 에멀젼을 제조하는 단계; 3) 에멀젼 안정화제 용액에 상기 유중수형 에멀젼을 유탁시켜 수중유형(oil in water, O/W) 에멀젼을 제조하는 단계; 및 4) 상기 수중유형 에멀젼에 과산화수소 분해 촉매를 첨가하여 과산화수소를 분해하면서 유기용매를 증발시키는 단계에 의해 제조된다. 본 발명에 따른 덮인 다공성 생분해성 고분자 미립구는 외부 표면이 생분해성 고분자 박막으로 덮여져 기공의 개구부가 막힌 구조를 갖고 있어 인체 투여 후 초기에 생리활성물질이 과도하게 방출되는 것을 제어할 수 있고, 이후 체내에서 생분해성 고분자 박막이 분해되면서 내부의 상호 연결된(interconnected) 기공 구조에 의해 생리활성물질이 지속적으로 방출되는 효과를 기대할 수 있어 서방형 약물전달체 및 조직재생용 지지체로 매우 유용하게 사용될 수 있다.
서방형 미립구, 약물전달체, 조직재생, 과산화수소, 덮인 다공성 표면
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