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公开(公告)号：KR101910047B1
公开(公告)日：2018-10-22
申请号：KR1020160089133
申请日：2016-07-14
IPC: C12N5/0793 , A61K31/045 , A61K31/05 , A23L1/30
Abstract: 본명세서는라티폴린을유효성분으로서포함하는조성물에관한것이다. 이러한본 명세서의조성물은산화적스트레스로부터신경세포를보호하고, 신경세포의사멸을억제하는효과를나타낸다. 또한, 세포내에서산화적스트레스의증가로인해발생하는세포사멸을억제하는항산화효소의발현을증가시킬수 있다. 따라서, 본명세서의조성물은산화적스트레스로부터신경세포의사멸로인하여발생될수 있는 2차적질병을예방, 개선또는치료하는효과를나타낼수 있어약학또는식품조성물로서사용될수 있다.
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公开(公告)号：KR1020170051933A
公开(公告)日：2017-05-12
申请号：KR1020150153660
申请日：2015-11-03
Applicant: 한국과학기술연구원
Abstract: 본발명은내부에물을저장하는공간이마련되고우수유입구를가지는저장장치, 상기저장장치에연결되고상기저장장치로부터공급된물을수목이식재되는복수의모듈내로분배하는공급장치및 상기공급장치에연결되고상기복수의모듈내로공급된물을집수하기위한회수장치를포함하고, 상기회수장치에수용된물은일측이상기회수장치에연결되고타측이상기저장장치에연결되는순환배관을따라다시상기저장장치로이동하는옥상녹화용관수시스템에관한것이다.
Abstract translation: 本发明涉及一种具有用于在其中储存水的空间并具有雨水入口的储存装置，连接到储存装置的供应装置，用于将从储存装置供应的水分配到多个模块中， 以及用于收集供应到所述多个模块中的水的水收集装置，其中容纳在所述水收集装置中的水连接到所述一个或多个机会用水装置并且连接到所述存储装置 移动屋顶绿化管水系统。
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公开(公告)号：KR1020160107624A
公开(公告)日：2016-09-19
申请号：KR1020150030603
申请日：2015-03-04
Applicant: 한국과학기술연구원
IPC: A61K31/12 , A61K31/404 , A61K31/282 , A23L1/30
CPC classification number: A61K31/12 , A23L33/10 , A61K31/282 , A61K31/404
Abstract: 본명세서는신규찰콘유도체화합물과이러한찰콘유도체화합물또는이의약학적으로허용가능한염을유효성분으로포함하는신독성감소용조성물에관한것이다. 본명세서의찰콘유도체화합물은하기화학식 1의구조를가지는것일수 있다. [화학식 1]상기화학식 1에서 A는,,또는이고, 상기 R내지 R는각각독립적으로수소원자; C내지 C알콕시; C내지 C알킬; 페닐; 불소, 염소, 브롬및 요오드로구성되는군으로부터선택되는할로겐; 니트로(-NO); 알릴옥시(allyloxy); 또는디메틸아민(-N(CH))일수 있다. 본명세서에따른조성물은신장독성을나타내는약물에의한신장세포의손상을보호하고신장독성을감소시켜신장을보호할수 있으며, 따라서약물성신장질환을예방하거나치료할수 있는효과를나타낸다.
Abstract translation: 本发明涉及一种用于还原肾毒性的组合物，其包含新型查耳酮衍生物化合物及其查耳酮衍生物化合物或其药学上可接受的盐作为活性成分。 本发明的查耳酮衍生物可以具有化学式1的结构。根据本发明，组合物可以保护肾细胞免于代表肾毒性的药物的损伤，并通过降低肾毒性来保护肾脏，从而显示出效果 预防或治疗药物性肾病。
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公开(公告)号：KR101607896B1
公开(公告)日：2016-03-31
申请号：KR1020140088551
申请日：2014-07-14
Applicant: 한국과학기술연구원
Abstract: 본발명은 (2,4,8,10)-N-이소부틸도데카-2,4,8,10-테트라엔아마이드를표준물질로하여소청룡탕의품질을판별및 품질을표준화하는방법을제공한다. 구체적으로, 소청룡탕의품질을판별하는방법으로소청룡탕일부를추출하여소청룡탕추출물을제조하는단계;및상기소청룡탕추출물내포함된소청룡탕표준물질의함량을측정하는단계를포함하고, 상기판별하고자하는품질은소청룡탕의항염증효능이며, 상기표준물질은 (2,4,8,10)-N-이소부틸도데카-2,4,8,10-테트라엔아마이드인소청룡탕의품질판별방법및 이를이용한품질표준화방법을제공한다. 또한상기와같은품질표준화방법을이용하여제조한항염증용소청룡탕을제공한다.
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35.发明公开진세노사이드 ２０(Ｓ)-알지3 또는 진세노사이드 ２０(Ｒ)-알지3의 함량비율이 증가된 가공 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물 有权加工PANAX SPP 植物提取物，其具有增加的茚三酮20（S）-RG 3或茚三酮20（R）-RG 3的含量比例，其制备方法和包含其的组合物
公开(公告)号：KR1020140047645A
公开(公告)日：2014-04-22
申请号：KR1020140037956
申请日：2014-03-31
Applicant: 한국과학기술연구원
IPC: A61K36/258 , A61K31/704 , A61P7/02 , A61P29/00 , A61P25/00
CPC classification number: A61K36/258 , A23L33/105 , A23L33/175 , A61K31/198 , A61K31/704 , A61K2236/333
Abstract: The present invention relates to an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extract with at least one amino acid selected from the group consisting of valine, arginine, and alanine at 100-130°C for 0.5-12 hours; a method for manufacturing the same; and a composition comprising the extract for anti-cancer, neuroprotection, inhibition of platelet aggregation, antioxidant, anti-inflammatory, renal protection, or anti-fatigue. The present invention also provides an extract of processed Panax genus plant obtained by maillard browning reaction of Panax genus extrac with at least one amino acid selected from the group consisting of leucine and glutamine at 100-130°C for 0.1-12 hours; a method for manufacturing the same; and an anti-cancer composition comprising the extract.
Abstract translation: 本发明涉及通过将亚麻提取物与选自缬氨酸，精氨酸和丙氨酸的至少一种氨基酸在100-130℃下进行0.5-12小时的美拉德褐变反应而获得的加工番荔枝属植物提取物 ; 其制造方法; 以及包含用于抗癌，神经保护，抑制血小板聚集，抗氧化，抗炎，肾脏保护或抗疲劳的提取物的组合物。 本发明还提供了将Panax属提取物的玉米褐变反应与100-130℃下选自亮氨酸和谷氨酰胺的至少一种氨基酸进行0.1-12小时的经加工的Panax属植物提取物; 其制造方法; 以及包含所述提取物的抗癌组合物。
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Patent Agency Ranking36.发明公开마이크로웨이브 조사에 의해 진세노사이드 알지3, 알지5 및 알케이1의 함량비율이 증가된 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물 审中-实审PANAX SPP。 具有通过微波辐照生产的茚满酮RG3，RG5和RK1的增加的含量的植物提取物，其制备方法和包含其的组合物
公开(公告)号：KR1020130132264A
公开(公告)日：2013-12-04
申请号：KR1020130036448
申请日：2013-04-03
Applicant: 한국과학기술연구원
IPC: A61K36/258 , A61K31/56 , A61K9/48 , A61K9/20
CPC classification number: A61K36/258 , A61K31/704 , A61K2236/37 , A61K2300/00
Abstract: The present invention provides Panax spp. plant extract which includes 90% or more of Rg3, Rk1, and Rg5 based on the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5 obtained by making microwave reaction with Panax spp. plant or the extract, a method for preparing the same, a pharmaceutical composition for improving anti-cancer agent side effects selected from immune degradation and anti-cancer agent tolerance, antioxidant, anti-cancer, antiinflammatory, brain function or cognitive skills, blood vessel relaxation, platelet coagulation suppression, dermatitis, or psoriasis and a composition for health supplement. [Reference numerals] (AA) Voltage (mV);(BB) Time (minute)
Abstract translation: 本发明提供了Panax spp。 基于通过与Panax spp进行微波反应获得的人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5的重量，含有90％以上的Rg3，Rk1和Rg5的植物提取物。 植物或提取物，其制备方法，用于改善选自免疫降解和抗癌药耐受性，抗氧化剂，抗癌，抗炎，脑功能或认知技能的抗癌剂副作用的药物组合物，血管 松弛，血小板凝血抑制，皮炎或银屑病以及健康补充剂的组合物。 （标号）（AA）电压（mV）;（BB）时间（分钟）
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公开(公告)号：KR1020130060798A
公开(公告)日：2013-06-10
申请号：KR1020110127052
申请日：2011-11-30
Applicant: 한국과학기술연구원
CPC classification number: A23L27/10 , A23L33/105 , A23V2002/00 , A23V2250/2112 , A23V2300/14
Abstract: PURPOSE: An amorphous turmeric extract and amorphous curcumin are provided through cooling below a melting point after heating a turmeric extract or curcumin to reach above the melting point. CONSTITUTION: An organic solvent extract of turmeric is obtained in a pure solution state by extracting turmeric with a solvent and filtering. The turmeric extract is heated at a range of 180-240 deg. C for 0.1-10 minutes, and amorphous curcumin is obtained by cooling with a temperature below 190 deg. C. A solubilization component of the turmeric extract includes an amorphous turmeric extract solution in which the amorphous turmeric extract is dissolved in a biocompatible solvent selected from one or more of a group composed of linear alcohol or branched alcohol with 1-4 carbons, poly ethylene glycol with 100-1,000 number average molecular weight, glycerol, acetic acid, and polyoxyethylene sorbitan fatty acid ester. [Reference numerals] (AA) Turmeric extract; (BB) Melted turmeric extract
Abstract translation: 目的：在加热姜黄提取物或姜黄素达到熔点以上之后，通过冷却至熔点以下，提供无定形姜黄提取物和无定形姜黄素。 构成：通过用溶剂萃取姜黄并进行过滤，得到纯溶液状态的姜黄有机溶剂提取物。 姜黄提取物在180-240度的范围内加热。 0.1至10分钟，通过在低于190度的温度下冷却获得无定形姜黄素。 C.姜黄提取物的增溶组分包括无定形姜黄提取物溶液，其中无定形姜黄提取物溶解在生物相容性溶剂中，所述生物相容性溶剂选自一种或多种由具有1-4个碳的直链醇或支链醇组成的组，聚乙烯 具有100-1,000数均分子量的二醇，甘油，乙酸和聚氧乙烯山梨糖醇酐脂肪酸酯。 （AA）姜黄提取物; （BB）熔黄姜提取物
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38.发明公开고삼 추출물을 함유하는 숙취 예방 또는 해소용 조성물 有权用于防止和/或排除包含A A ING ING ING ING ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS ENS
公开(公告)号：KR1020130047399A
公开(公告)日：2013-05-08
申请号：KR1020110112394
申请日：2011-10-31
Applicant: 한국과학기술연구원
CPC classification number: A61K36/489 , A23L33/105 , A23V2002/00 , A61K2236/30 , A23V2200/334 , A23V2250/21
Abstract: PURPOSE: A composition containing a Sophora flavescens extract is provided to enhance activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, and to effectively relieve hangover. CONSTITUTION: A pharmaceutical composition for preventing or removing alcoholic hangover contains one or more selected from the group consisting of a Sophora flavescens extract, a dried material thereof, and a concentration of the extract as active ingredients. The extract is a crude extract which is prepared using water, C1-C4 straight or branched alcohols, methyl chloride, ethyl acetate, and acetone; and a fraction which is prepared from the crude extract using hexane, chloroform, ether, methyl chloride, ethyl acetate, butanol, and water. [Reference numerals] (AA) Ethanol decomposition test; (BB) Ethanol concentration in blood(%, v/v); (CC) Control group; (DD) Ethanol injected group; (EE) Comparison group 1; (FF) Comparison group 2
Abstract translation: 目的：提供含有苦参提取物的组合物，以提高醇脱氢酶和乙醛脱氢酶的活性，有效缓解宿醉。 构成：用于预防或去除酒精宿醉的药物组合物含有选自苦参提取物，其干燥物质和提取物浓度作为活性成分的一种或多种。 提取物是使用水，C1-C4直链或支链醇，甲基氯，乙酸乙酯和丙酮制备的粗提物; 和使用己烷，氯仿，乙醚，甲基氯，乙酸乙酯，丁醇和水从粗提取物制备的馏分。 （标号）（AA）乙醇分解试验; （BB）血液中乙醇浓度（％，v / v）; （CC）对照组; （DD）乙醇注射组; （EE）比较组1; （FF）比较组2
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39.发明授权마이크로웨이브 조사에 의해 진세노사이드 알지3, 알지5 및 알케이1의 함량비율이 증가된 파낙스속 식물 추출물, 그 제조방법, 및 그 가공 파낙스속 식물 추출물을 포함하는 조성물 有权PANAX SPP。 具有通过微波辐照生产的茚满酮RG3，RG5和RK1的增加的含量的植物提取物，其制备方法和包含其的组合物
公开(公告)号：KR101260047B1
公开(公告)日：2013-05-06
申请号：KR1020130007651
申请日：2013-01-23
Applicant: 한국과학기술연구원
IPC: A61K36/258 , A61K9/48 , A61K9/20 , A61K9/16
CPC classification number: A61K36/258 , A61K31/704 , A61K2236/37 , A61K2300/00
Abstract: PURPOSE: A Panax species plant extract having the increased content of ginsenoside Rg5 and Rk1 by microwave irradiation, a manufacturing method thereof, and a composition containing the processed Panax species plant extract are provided to enhance an effect of Rg5 and Rk1 compared to an extract by simple thermal-processing. CONSTITUTION: A manufacturing method of a Panax species plant extract comprises: a step of irradiating Panax species plants or an extract thereof with microwaves. The Panax species plant or the extract contains more than 90% of Rg3, Rk1, and Rg5 to the weight of ginsenoside Rb1, Rc, Rb2, Rd, Rg3, Rk1 and Rg5. The microwave irradiation is performed at 150-190 deg. C for 30-90 minutes while pressurizing. The microwave irradiation is performed under 2-100 atmospheric pressure. The Panax species plant extract has a ratio of ginsenoside (Rg5+Rk1)/(Rg3) of 2 or greater. [Reference numerals] (AA) Voltage(mv); (BB) Time(minutes)
Abstract translation: 目的：提供通过微波照射提高人参皂甙Rg5和Rk1含量增加的Panax种植物提取物，其制备方法和含有加工的Panax种植物提取物的组合物，以提高Rg5和Rk1与提取物相比的作用 简单的热处理。 构成：人参植物提取物的制造方法包括：将微生物种类植物或其提取物照射到微波的步骤。 人参植物或提取物含有人参皂甙Rb1，Rc，Rb2，Rd，Rg3，Rk1和Rg5重量的Rg3，Rk1和Rg5的90％以上。 微波照射在150-190度进行。 C加压30-90分钟。 微波照射在2-100大气压下进行。 人参植物提取物的人参皂甙（Rg5 + Rk1）/（Rg3）的比值为2以上。 （附图标记）（AA）电压（mv）; （BB）时间（分钟）
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40.发明授权
公开(公告)号：KR101189191B1
公开(公告)日：2012-10-09
申请号：KR1020100060181
申请日：2010-06-24
Applicant: 한국과학기술연구원
CPC classification number: A61K36/77 , A61K36/31 , A61K36/488 , A61K36/539 , A61K2300/00
Abstract: 본 발명은 용안육 추출물, 또는 용안육이 포함된 혼합 추출물을 함유하는 퇴행성 뇌신경질환의 예방 또는 치료용 조성물에 관한 것으로, 본 발명의 조성물은 용안육 추출물 또는 용안육이 포함된 혼합 추출물을 유효성분으로 함유함으로써, 퇴행성 뇌신경질환의 예방 또는 치료 효과가 현저히 우수하며 특히 본 발명의 조성물은 도파민성 신경계에 선택적 작용을 하는 MPTP에 의한 신경 독성과 알파-시누클레인(alpha-synuclein) 단백질 응집에 의한 신경 독성으로부터 도파민 신경세포를 유의성 있게 보호함으로써 퇴행성 뇌신경질환을 효과적으로 예방 또는 치료할 수 있다.
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