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31.发明授权옻나무 추출물, 이의 분획물 또는 상기 분획물에서 분리한화합물을 포함하는 당뇨병 합병증 예방 및 치료용 조성물 有权该组合物包含提取物，级分和用于预防和治疗糖尿病并发症的Rhus verniciflua的分离化合物
公开(公告)号：KR100926454B1
公开(公告)日：2009-11-13
申请号：KR1020070054855
申请日：2007-06-05
Applicant: 한국과학기술연구원
Abstract: 본 발명은 옻나무 추출물, 이의 분획물 또는 상기 분획물에서 분리한 화합물을 유효성분으로 포함하는 당뇨병 합병증 예방 및 치료용 조성물에 관한 것으로서, 더욱 상세하게는 물, 알코올, 또는 이들의 혼합물을 용매로 하여 추출되는 옻나무 추출물, 이의 분획물 및 상기 분획물에서 분리한 화합물은 당뇨병 합병증의 원인인 소르비톨 축적을 일으키는 알도스 환원효소 억제효과 및 최종당화산물 억제효과를 나타내며, 또한 세포독성이 없는 안정한 물질로 확인되었으므로 당뇨 합병증 예방 및 치료용 조성물로 유용하게 이용될 수 있다.
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公开(公告)号：KR100850475B1
公开(公告)日：2008-08-07
申请号：KR1020070027571
申请日：2007-03-21
Applicant: 한국과학기술연구원
Abstract: A food composition comprising the extract of Cutleria cylindrical is provided to improve cancer chemoprevention by inducing activity of quinone reductase as a marker enzyme of cancer prevention and cause no toxicity to human cells. A food composition for cancer chemoprevention comprises 0.001-99.9 wt.% based on the total weight of food, or 0.001-0.1g, preferably 0.05-0.1g in 100 ml of drink of the extract of Cutleria cylindrical which is prepared by extracting Cutleria cylindrical with water or organic solvent such as ethanol, and is formulated as chewing gum, caramel, candy, ice cream, confectionaries, drink, mineral water, alcohol drink, or vitamin- or mineral-containing food.
Abstract translation: 提供包含圆锥形切片的提取物的食物组合物，以通过诱导醌还原酶的活性作为预防癌症的标记酶而引起对人体细胞毒性的改善来改善癌症化学预防。 用于癌症化学预防的食物组合物包含基于食物总重量的0.001-99.9重量％，或0.001-0.1g，优选0.05-0.1g，在100毫升卷心菜提取物的饮料中，其通过提取Cutleria圆柱形 配合水或有机溶剂如乙醇，并配制成口香糖，焦糖，糖果，冰淇淋，糖果，饮料，矿泉水，酒精饮料或维生素或矿物质食品。
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公开(公告)号：KR100847806B1
公开(公告)日：2008-07-23
申请号：KR1020070028741
申请日：2007-03-23
Applicant: 한국과학기술연구원
CPC classification number: A61K8/97 , A23L33/105 , A61K36/899 , A61K2236/37 , A61K2800/522
Abstract: A method for extraction of leaves of Phyllostachys nigra is provided to prevent destruction of natural antioxidants and improve extraction yield by using high hydrostatic pressure without heat treatment, and inhibit environment pollution by using water as solvent. A method for extraction of leaves of Phyllostachys nigra comprises the steps of: (a) adding water into the dried leaves of Phyllostachys nigra; (b) inserting the water added leaves of Phyllostachys nigra into a high hydrostatic pressure device and treating it under the pressure of 200MPa or more for 1-3 minutes; and (c) leaving the pressure-treated leaves of Phyllostachys nigra at room temperature to extract antioxidants from the leaves of Phyllostachys nigra. A cosmetic composition contains the antioxidants extracted from the leaves of Phyllostachys nigra and is formulated as soap, lotion, cream, pack or solution. Further, a step of hydrating the leaves of Phyllostachys nigra is additionally comprised between the step (a) and the step (b) in the method.
Abstract translation: 提供黑叶提取方法，以防止天然抗氧化剂的破坏，并且通过使用高温静压不经热处理提高提取率，并通过使用水作为溶剂来抑制环境污染。 一种黑叶提取叶片的方法，包括以下步骤：（a）将黑麦黑叶子的叶子加入水中; （b）将黑曲霉加入的叶片插入高静水压装置中，在200MPa或更高的压力下处理1-3分钟; 和（c）将黑曲霉的加压处理的叶离开室温以从黑木叶中提取抗氧化剂。 化妆品组合物含有从黑叶木叶提取的抗氧化剂，并配制成肥皂，洗剂，霜剂，包装或溶液。 此外，在该方法中的步骤（a）和步骤（b）之间还包括水分黑木叶子的步骤。
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公开(公告)号：KR102224780B1
公开(公告)日：2021-03-09
申请号：KR1020190138960
申请日：2019-11-01
Applicant: 한국과학기술연구원 , 고려대학교 산학협력단
IPC: A61K36/61 , A61K39/395 , A61K45/06 , A61P35/00 , A23L33/105 , A23L33/17 , A61K39/00
Abstract: 본발명은정향추출물을포함하는대장암표적치료제의항암활성증진용약학적조성물에관한것으로, 보다상세하게는정향추출물및 항암제를포함하는대장암예방또는치료용조성물; 정향추출물을포함하는항암활성증진용식품또는식품첨가물; 및대장암표적치료제및 정향추출물을포함하는조성물을인간을제외한개체에투여하는단계를포함하는대장암치료방법에관한것이다. 본발명에따른조성물은대장암표적치료제와병용할경우, 대장암표적치료제의항암활성을증진시킬수 있다. 따라서, 본발명에따른조성물은항암활성증진용조성물로유용하게사용될수 있다.
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公开(公告)号：KR101826673B1
公开(公告)日：2018-02-08
申请号：KR1020160067553
申请日：2016-05-31
Applicant: 한국과학기술연구원
IPC: A23L1/30 , A61K36/344
CPC classification number: A61K36/344 , A23L33/135 , A23V2002/00 , A61K35/741 , A61K2035/115 , C12N1/20
Abstract: 본명세서에는신규한용도로사용되는, 더덕추출물을유효성분으로함유하는조성물이개시된다. 일측면에서있어서, 본발명의더덕추출물을유효성분으로함유하는조성물은, 장내유익균의증식을촉진하고, 유해균의증식을억제하고, 장내단쇄지방산의함량을증가시키키며, 장내균총을개선할수 있다. 또한, 본발명의조성물을이용하면, 장건강또는장 기능을개선할수 있으며, 배변기능을개선할수 있다. 또한, 본발명의조성물을프로바이오틱스와병용하면, 프로바이오틱스와의시너지효과를얻을수 있다. 한편, 본발명의더덕추출물을포함하는조성물은, 천연재료를이용하여제조되기때문에, 인체에부작용이없는장점이있다.
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Patent Agency Ranking36.发明授权벌개미취의 추출물, 분획물 또는 이로부터 분리한 짐나스테르코리아인 Ｂ 화합물을 유효성분으로 함유하는 간 보호 또는 개선용 조성물 有权含有肝保护的科罗拉多州科罗拉多州的提取物，级分和体操师K的组合物
公开(公告)号：KR101187032B1
公开(公告)日：2012-09-28
申请号：KR1020100046430
申请日：2010-05-18
Applicant: 한국과학기술연구원
Abstract: 본 발명은 벌개미취(
Gymnaster
koraiensis ) 추출물, 분획물 또는 이로부터 분리한 짐나스테르코리아인 B 화합물을 유효성분으로 함유하는 간 보호용 또는 간 기능 개선용 조성물에 관한 것으로서, 간 손상에 대한 간 보호용 또는 간 기능 개선용 약학적 조성물 또는 식품으로 유용하게 이용될 수 있다.-
公开(公告)号：KR1020100089549A
公开(公告)日：2010-08-12
申请号：KR1020090008855
申请日：2009-02-04
Applicant: 한국과학기술연구원
Inventor： 노주원 , 판철호 , 정상훈 , 김철영 , 엄병헌 , 이샛별 , 강경수 , 유지혜 , 차광현 , 구송이 , 송대근 , 이은하 , 이희주 , 윤지호 , 김명수 , 안수용 , 김종환 , 강석우
IPC: A23L1/30 , A61P35/00 , A61K36/282 , A23L2/38
CPC classification number: A61K36/28 , A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2250/21 , A23V2300/14 , A23V2300/18
Abstract: PURPOSE: A composition containing extract and portions of southernwood wild plants as an active ingredient is provided to activate quinone reductase which is an indicator enzyme for preventing cancer and to activate an antioxidant response element by including extracts and portions of the southernwood wild plants including Adenocaulon himalaicum or Artemisia dubia. CONSTITUTION: A composition for preventing cancers contains extracts and portions of southernwood wild plants including Adenocaulon himalaicum and Artemisia dubia as an active ingredient. The extracts are obtained by extracting dried Adenocaulon himalaicum or Artemisia dubia using alcohol having a carbon number of 1-4 or a mixed solvent. The portions are n-hexane portions, ethylacetate portions, n-butanol portions, or water portions.
Abstract translation: 目的：提供一种含有提取物和南部野生植物部分作为活性成分的组合物，用于活化醌还原酶，该还原酶是预防癌症的指示酶，并通过包括南木野生植物的提取物和部分，包括喜马拉松（Adenocaulon himalaicum） 或艾蒿（Artemisia dubia）。 构成：用于预防癌症的组合物含有南木野生植物的提取物和部分，其中包括Adenocaulon himalaicum和Artemisia dubia作为活性成分。 通过使用碳数为1-4的醇或混合溶剂提取干燥的Adenocaulon himalaicum或艾蒿，得到提取物。 这些部分是正己烷部分，乙酸乙酯部分，正丁醇部分或水部分。
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38.发明公开옻나무 추출물, 이의 분획물 또는 상기 분획물에서 분리한화합물을 포함하는 당뇨병 합병증 예방 및 치료용 조성물 有权包含RHUS VERNICIFLUA预防和治疗糖尿病并发症的提取物，部位和分离化合物的组合物
公开(公告)号：KR1020080107049A
公开(公告)日：2008-12-10
申请号：KR1020070054855
申请日：2007-06-05
Applicant: 한국과학기술연구원
Abstract: An agent for preventing and treating diabetes complication, and a health food are provided to inhibit the activity of the final sugar product and the aldose reductase. An agent for preventing and treating diabetes complication contains an extract of a lacquer tree (Rhus verniciflua) obtained by using water, an alcohol or their mixture as a solvent. Preferably the agent contains further an organic solvent fraction extracted by using an organic solvent. Preferably the organic solvent is n-hexane, methylene chloride, ethyl acetate or n-butanol.
Abstract translation: 提供了用于预防和治疗糖尿病并发症的药剂和保健食品以抑制最终糖产品和醛糖还原酶的活性。 用于预防和治疗糖尿病并发症的药剂含有通过使用水，醇或其混合物作为溶剂获得的漆树（Rhus verniciflua）的提取物。 优选地，该试剂还含有通过使用有机溶剂提取的有机溶剂级分。 有机溶剂优选为正己烷，二氯甲烷，乙酸乙酯或正丁醇。
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公开(公告)号：KR100856486B1
公开(公告)日：2008-09-04
申请号：KR1020070032294
申请日：2007-04-02
Applicant: 한국과학기술연구원
IPC: A61K36/88
Abstract: A method for extraction of tectoridin and tectorigenin from the rhizomes of Belamcanda chinensis is provided to reduce the extraction time, improve the extraction yield and enhance environment and human affinity by using only water and ethanol as solvent under high temperature and high pressure. The tectoridin and tectorigenin are extracted from the rhizomes of Belamcanda chinensis through SWE(subcritical water extraction) by heating the rhizomes of Belamcanda chinensis in a mixed solvent containing water and 30-100 vol.% of ethanol to high temperature such as 80 deg. C or more, preferably 80-200 deg. C under high pressure condition such as 1-15 MPa.
Abstract translation: 提供了一种从中华白兰地根茎提取t idin素和t ector素的方法，通过在高温高压下仅使用水和乙醇作为溶剂，减少提取时间，提高提取产率，增强环境和人亲和力。 通过SWE（亚临界水提取），通过在含有水和30-100体积％乙醇的混合溶剂中加热中华白兰地根茎至80度的高温，从枸杞子根茎中提取鸢尾苷和t ector素。 ℃以上，优选为80〜200度。 C在高压条件下，如1-15MPa。
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公开(公告)号：KR100850474B1
公开(公告)日：2008-08-07
申请号：KR1020080046221
申请日：2008-05-19
Applicant: 한국과학기술연구원
Abstract: A pharmaceutical composition comprising the extract of Cutleria cylindrical is provided to induce activity of quinone reductase, lead no an activity of phase 1 detoxification enzyme system but an activity of phase 2 detoxification enzyme system, inhibit cytotoxicity, and suppress increase carcinogenic and procarcinogenic materials and promote their release. A pharmaceutical composition for cancer chemoprevention comprises 0.001-99.9 wt.% of the extract of Cutleria cylindrical which is prepared by washing Cutleria cylindrical collected with water to remove foreign substances and salt, drying the Cutleria cylindrical, extracting the dried Cutleria cylindrical with solvent, preferably ethanol, filtering the extract of Cutleria cylindrical, and vacuum-concentrating and drying the filtered Cutleria cylindrical extract, and is formulated as powder, granule, tablet, capsule, suspension, emulsion, syrup, aerosol, ointment, cream, suppository or sterile injection solution, wherein the daily dosage of the Cutleria cylindrical extract is 0.001-1000 mg/kg.
Abstract translation: 提供包含圆锥形切片提取物的药物组合物以诱导醌还原酶的活性，不含相1脱毒酶系统的活性，但是第二阶段解毒酶体系的活性，抑制细胞毒性并抑制增加致癌和致癌物质并促进 他们的释放。 用于癌症化学预防的药物组合物包含通过洗涤用水收集的Cutleria圆柱体以除去外来物质和盐，干燥圆锥状切片，用溶剂提取干燥的Cutleria圆柱形的Cutleria圆柱形提取物的0.001-99.9重量％ 乙醇，过滤圆锥形切片提取物，真空浓缩和干燥过滤的西葫芦圆柱形提取物，配制成粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，气溶胶，软膏，霜剂，栓剂或无菌注射溶液 其中，圆锥形提取物的日剂量为0.001〜1000mg / kg。
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