-
公开(公告)号：KR1020170015660A
公开(公告)日：2017-02-09
申请号：KR1020150107823
申请日：2015-07-30
Applicant: 충남대학교산학협력단
Abstract: 본발명은당단백질의부위-특이적 O-당펩타이드생성및 분석방법에관한것으로서, 좀더 구체적으로는비특이적단백질분해효소처리를이용하여 O-당펩타이드를생성하여당사슬이결합된위치를확인할수 있을뿐 아니라당자리에결합된당사슬의종류, 당사슬변이체및 당사슬의구조를포함한 O-당사슬의다양성을정량적으로프로파일링할 수있는분석방법에관한것이다. 본발명은종래β-제거를통한 O-당사슬다양성분석방법에비하여시료처리시간이짧고, 생성된 O-당펩타이드는펩타이드길이가짧아질량분석기적용이용이하다.
-
-
公开(公告)号：KR101452730B1
公开(公告)日：2014-10-23
申请号：KR1020140019067
申请日：2014-02-19
Applicant: 한국과학기술원
IPC: C12Q1/68 , G01N33/574 , G01N33/68
CPC classification number: G01N33/57446 , G01N2333/00 , G01N2333/47 , G01N2400/38
Abstract: The present invention relates to a method to diagnose gastric cancer by detecting the changes in the sugar chain, and to a kit to diagnose gastric cancer and, more specifically, to a method to diagnose gastric cancer based on the reduction of a high mannose structure of an N-sugar chain compared with a normal person in case of increasing fucosylation of an N-linked glycosylation of haptoglobin derived from a gastric cancer patient detected by a lectin or weight analysis method; and increasing or practically changing the structures of the specific sugar chain in accordance to an antennary division using a lectin or a weight analysis method as a diagnosis while the detected N-sugar chain structures uses lectin or weight analysis method as a diagnosis marker, and to a kit diagnosing gastric cancer.
Abstract translation: 本发明涉及通过检测糖链的变化来诊断胃癌的方法，以及用于诊断胃癌的试剂盒，更具体地，涉及一种基于降低高甘露糖结构的方法来诊断胃癌 在通过凝集素或重量分析方法检测的来自胃癌患者的触珠蛋白的N-连接糖基化的岩藻糖基化增加的情况下与正常人相比的N-糖链; 并且使用凝集素或重量分析方法作为诊断来增加或实际地改变特定糖链的结构，同时检测到的N-糖链结构使用凝集素或重量分析方法作为诊断标记，并且 一套诊断胃癌的试剂盒。
-
-
Search Results
33
records
(took 0.018 seconds)
