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公开(公告)号：KR101348655B1
公开(公告)日：2014-01-08
申请号：KR1020100077699
申请日：2010-08-12
Applicant: 한국전자통신연구원
Abstract: 본 발명은 미세 다단 채널을 포함하는 플라스틱 미세유체 제어 장치 및 그 제조 방법에 관한 것이다. 본 발명은 미세유체 제어 장치에 있어서, 하부 기판; 및 상기 하부 기판과 접하며, 상기 하부 기판과의 접합면에 적어도 두가지의 깊이를 갖는 다단의 미세 채널을 갖는 유로 기판을 포함한다. 본 발명에 따르면, 다양한 채널 깊이를 갖는 다단의 미세 채널을 이용하여 유체를 제어함으로써, 채널의 깊이 방향으로 모세관력을 조절하여 유체 이송을 정밀하게 제어하는 미세유체 제어 장치를 제공할 수 있다. 또한, 포토리소그래피 공정을 반복하여 다단의 미세 패턴을 형성하고 이를 전사함으로써, 표면이 평탄하고 채널 높이가 정밀하게 제어된 다단의 미세 채널을 용이하게 형성할 수 있다.
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公开(公告)号：KR1020130014322A
公开(公告)日：2013-02-07
申请号：KR1020120016463
申请日：2012-02-17
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/532 , G01N27/72 , B82Y15/00
Abstract: PURPOSE: A multiple analyzer and a method for analyzing cancer cells in blood are provided to analyze cancer cells in each cancer. CONSTITUTION: A multiple analyzer comprises a magnetophoresis sorting part, a magnetic field measuring unit, and an analyzing and determining unit. The magnetophoresis sorting part comprises: a solution inlet; a saline solution inlet; a channel which is connected to the solution inlet and the saline solution inlet; one or more ferromagnetism patterns which are placed under the bottom of the channel; a first discharging path which is connected to the channel and discharges a first kind of material contained in the solution; and a second discharge path which is connected to the channel and discharges a second kind of material contained in the solution. A method for analyzing cancer cells in blood comprises the following steps: a step of mixing blood to be tested with a magnetic nanoparticle which is conjugated with a cancer cell-specific antibody, and preparing a mixture solution(S10); a step of dividing the mixture solution into normal cells and cancer cells by magnetophoresis(S20); a step of continuously measuring a magnetic field of the cancer cells(S30); and a step of analyzing and determining cancer cells in each cancer using the magnetic field of the cancer cell(S40). [Reference numerals] (AA) Blood; (BB) Magnetic nanoparticles; (CC) Mixture solution; (S20) Magnetophoresis division: dividing cancer cells and normal cells; (S30) Continuously measuring the magnetic field of the cancer cells; (S40) Analyzing/determining the cancer kinds of cancer cells
Abstract translation: 目的：提供多种分析仪和分析血液中癌细胞的方法，以分析各种癌症中的癌细胞。 构成：多分析仪包括磁电泳分选部，磁场测定部以及分析判断部。 磁电泳分选部分包括：溶液入口; 盐水溶液入口; 连接到溶液入口和盐水溶液入口的通道; 放置在通道底部下方的一个或多个铁磁图案; 第一排出路径，其连接到所述通道并排出所述溶液中包含的第一种材料; 以及第二排出路径，其连接到通道并排出溶液中包含的第二种材料。 用于分析血液中的癌细胞的方法包括以下步骤：将待测血液与与癌细胞特异性抗体结合的磁性纳米颗粒混合，制备混合液（S10）; 通过磁电泳将混合溶液分成正常细胞和癌细胞的步骤（S20）; 连续测量癌细胞的磁场的步骤（S30）; 以及使用癌细胞的磁场分析和确定各癌症中的癌细胞的步骤（S40）。 （附图标记）（AA）血液; （BB）磁性纳米粒子; （CC）混合溶液; （S20）磁电泳分割：分割癌细胞和正常细胞; （S30）连续地测量癌细胞的磁场; （S40）分析/确定癌细胞的癌症种类
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公开(公告)号：KR1020130014305A
公开(公告)日：2013-02-07
申请号：KR1020110130311
申请日：2011-12-07
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/553 , G01N27/72
Abstract: PURPOSE: A multiple sorting apparatus and a method for sorting cancer cells in blood using the same are provided to sort the cancer cells by each kind of cancer and to simply diagnose cancer development. CONSTITUTION: A multiple sorting apparatus(100) comprises a first magnetophoresis sorting part(MP1) and a second magnetophoresis sorting part(MP2). The first magnetophoresis sorting part has a first channel(CH1). One side of the first channel is connected with a mixture solution inlet port(IP1) and a first saline solution inlet port(IP2). The other side of the first channel is connected with a first outlet port(OP1) and a preliminary separation path(PSP). The second magnetophoresis sorting part has a second channel. One side of the first channel is connected with a second saline solution inlet port(IP3) and a preliminary separation path. The other side of the second channel is connected with the second outlet port(OP2).
Abstract translation: 目的：提供使用其分选血液中的癌细胞的多重分选装置和方法，以通过各种癌症对癌细胞进行分类并简单地诊断癌症发展。 构成：多重分选装置（100）包括第一磁电泳分选部（MP1）和第二磁电泳分选部（MP2）。 第一磁电泳分选部具有第一通道（CH1）。 第一通道的一侧与混合溶液入口（IP1）和第一盐水溶液入口（IP2）连接。 第一通道的另一侧与第一出口（OP1）和初步分离路径（PSP）连接。 第二磁电泳分选部件具有第二通道。 第一通道的一侧与第二盐水溶液入口（IP3）和初步分离路径连接。 第二通道的另一侧与第二出口（OP2）连接。
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公开(公告)号：KR1020120130677A
公开(公告)日：2012-12-03
申请号：KR1020110123504
申请日：2011-11-24
Applicant: 한국전자통신연구원
CPC classification number: B01D71/021 , B01D69/02 , B01D2325/028 , C01B32/182 , C23C14/0605
Abstract: PURPOSE: A separating apparatus using self-assembling material-based graphene nanostructure as a separating part and a manufacturing method of the same are provided to improve the reducibility of components and to be integrated with microfluidic channels and electric components. CONSTITUTION: A manufacturing method of a separating apparatus using self-assembling material-based graphene nanostructure includes the following steps: protective layers are formed on the lower side and the upper side of a substrate(201); parts of the lower side and the upper side of the substrate are exposed by patterning the protective layers; the protective layers on the exposed parts of the substrate are etched; graphene nanostructure with columnar pores is transferred on the upper side of the substrate; and a nanostructure etching mask layer is removed from the graphene nanostructure.
Abstract translation: 目的：提供使用自组装材料的石墨烯纳米结构作为分离部分的分离装置及其制造方法，以提高部件的还原性并与微流体通道和电气部件集成。 构成：使用自组装材料的石墨烯纳米结构的分离装置的制造方法包括以下步骤：在基板（201）的下侧和上侧形成保护层; 通过图案化保护层来暴露基板的下侧和上侧的部分; 蚀刻衬底的暴露部分上的保护层; 具有柱状孔的石墨烯纳米结构转移到基板的上侧; 并且从石墨烯纳米结构去除纳米结构蚀刻掩模层。
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公开(公告)号：KR1020110115065A
公开(公告)日：2011-10-20
申请号：KR1020100091588
申请日：2010-09-17
Applicant: 한국전자통신연구원
Abstract: 본 발명은 정량이 가능한 일회용 바이오 샘플 채취 및 토출 장치에 관한 것으로서, 관 형태를 가지며, 일측 끝단의 샘플 주입구로부터 소정 거리 이격된 위치에 형성된 개구부를 포함하는 유체 채널; 상기 유체 채널의 타측 끝단에 결합되며, 상기 유체 채널에 인입되어 채취된 샘플의 토출을 조절하는 조절부를 포함한다. 본 발명에 따르면, 일정한 양의 샘플을 용이하게 채취할 수 있다. 또한, 샘플 채취 장치의 구조가 간단하므로, 저렴한 비용으로 일회용 장치로 제작이 가능하다.
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Patent Agency Ranking
公开(公告)号：KR1020100073061A
公开(公告)日：2010-07-01
申请号：KR1020080131644
申请日：2008-12-22
Applicant: 한국전자통신연구원
CPC classification number: G01N21/253 , G01N21/8483 , G01N2201/0256 , G01N2201/0826
Abstract: PURPOSE: A liquid sample analysis chip reading system, an analysis method using thereof, and a ubiquitous reading system are provided to effectively obtain the optical sensing result accurately, and to receive or transfer the optical sensing result to a remote site. CONSTITUTION: A ubiquitous liquid sample analysis chip reading system(100) comprises the following; an analysis chip(210) including three sensors applied with the same samples; a lighting-emitting area(132) including three light sources emitting each colors; three light guide paths; a photo diode(134) including three light receiving devices; a controller(118) for analyzing the electric signal transformed by the photo diode; a display unit(120) displaying the result from the controller; and a communication unit for transferring the result.
Abstract translation: 目的：提供液体样品分析芯片读取系统，其使用的分析方法和普遍存在的读取系统，以有效地获得光学感测结果，并将光学感测结果接收或传输到远程站点。 构成：普遍存在的液体样品分析芯片读取系统（100）包括： 分析芯片（210），其包括应用相同样本的三个传感器; 包括发射各种颜色的三个光源的发光区域（132） 三条导光路; 包括三个光接收装置的光电二极管（134） 用于分析由光电二极管变换的电信号的控制器（118）; 显示单元（120），显示来自控制器的结果; 以及用于传送结果的通信单元。
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公开(公告)号：KR1020100066272A
公开(公告)日：2010-06-17
申请号：KR1020090025206
申请日：2009-03-25
Applicant: 한국전자통신연구원
Abstract: PURPOSE: A method for manufacturing a fine membrane filter having an opening having nanoscopic width by photo lithography process or electron-beam lithography process is provided. CONSTITUTION: A method for manufacturing a fine filter comprises: a step of forming a mold(30) having a first width protrusion(36); a step of forming filter membrane(42) at one side of a substrate; a step of coating a resist film on the filter membrane; a step of forming a resist pattern having a first opening to contact with the filter membrane; a step of forming a second opening by etching the filter membrane using a etching mask; a step of removing the resist film; and a step of exposing the opening of the filter membrane.
Abstract translation: 目的：提供一种通过光刻工艺或电子束光刻工艺制造具有纳米宽度的开口的细膜过滤器的方法。 制造精细过滤器的方法包括：形成具有第一宽度突起（36）的模具（30）的步骤; 在衬底的一侧形成过滤膜（42）的步骤; 在过滤膜上涂布抗蚀剂膜的步骤; 形成具有与过滤膜接触的第一开口的抗蚀剂图案的步骤; 通过使用蚀刻掩模蚀刻所述过滤膜来形成第二开口的步骤; 去除抗蚀剂膜的步骤; 以及暴露过滤膜的开口的步骤。
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公开(公告)号：KR1020090059448A
公开(公告)日：2009-06-11
申请号：KR1020070126314
申请日：2007-12-06
Applicant: 한국전자통신연구원
CPC classification number: C12M23/20 , B01L3/5027 , B01L7/00 , C12M23/16 , C12M41/12 , Y10T29/49124
Abstract: A portable small cell incubator is provided to supply gas which is necessary in culturing animal cell and regulate the temperature of culture medium. A portable small cell incubator contains an upper plate(100), lower plate(300) and middle thin film(200). The upper plate contains a minute heat wire(110) and medium storage space(130) by PDMS(polydimethylsiloxane). The lower plate contains a storage space(330) of liquid and solid and gas movement channel. A method for manufacturing the incubator comprises: a step of depositing a metal on the lower plate; a step of forming minute heat wire; a step of attaching a PDMS(polydimethylsiloxane) film on the upper side of lower plate; a step of attaching PDMS thin film having gas permeability on the upper side of gas movement channel; and a step of attaching the upper plate.
Abstract translation: 提供便携式小细胞培养器来提供培养动物细胞所必需的气体并调节培养基的温度。 便携式小电池培养箱包含上板（100），下板（300）和中间薄膜（200）。 上板由PDMS（聚二甲基硅氧烷）包含微小的热丝（110）和介质储存空间（130）。 下板包含液体和固体和气体运动通道的储存空间（330）。 一种用于制造所述培养箱的方法，包括：在所述下板上沉积金属的步骤; 形成分热丝的步骤; 在下板的上侧附着PDMS（聚二甲基硅氧烷）膜的步骤; 在气体流动通道的上侧附着具有透气性的PDMS薄膜的步骤; 以及附接上板的步骤。
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公开(公告)号：KR100889727B1
公开(公告)日：2009-03-24
申请号：KR1020070119701
申请日：2007-11-22
Applicant: 한국전자통신연구원
IPC: G01N33/49 , G01N33/487
Abstract: An open type blood plasma separating filter unit is provided to separate a blood plasma from blood by using capillary force without help of any external devices such as a syringe pump. An open type blood plasma separating filter unit comprises a bottom substrate(100), a top substrate(200), and a filter member(300). The bottom substrate includes one or more blood plasma guiding channel(130), a blood plasma chamber, and one or more air outlet. The blood plasma guiding channel has a narrow and long capillary shape. The blood plasma chamber is linked with the blood plasma guiding channel. The filter member is closely adhered to a top of the blood plasma guiding channel to separate the blood plasmas and blood cells from the blood.
Abstract translation: 提供一种开式血浆分离过滤器单元，用于通过使用毛细管力将血浆与血液分离，而无需任何外部装置如注射泵。 开放型血浆分离过滤器单元包括底部基底（100），顶部基底（200）和过滤元件（300）。 底部基底包括一个或多个血浆引导通道（130），血浆室和一个或多个空气出口。 血浆引导通道具有窄而长的毛细管形状。 血浆室与血浆引导通道连接。 过滤构件紧密地附着在血浆引导通道的顶部，以将血浆和血液细胞与血液分离。
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公开(公告)号：KR1020080052296A
公开(公告)日：2008-06-11
申请号：KR1020070083835
申请日：2007-08-21
Applicant: 한국전자통신연구원
CPC classification number: F04B19/006 , B01L3/502707 , B01L3/50273 , B01L2300/0816 , B01L2400/0439 , B01L2400/0496 , F04F7/00 , Y10T29/42 , Y10T137/86027
Abstract: A microfluidic transport device and a manufacturing method thereof are provided to enable mass production at low cost by using commercialized semiconductor manufacturing technology based on silicone. A microfluidic transport device comprises a substrate(101), a piezoelectric film(102), an IDT(Inter Digitated Transducer) electrode(103) and a fluid path(105). The piezoelectric film is formed on the upper part of the substrate. The IDT electrode for energy conversion is formed on the piezoelectric film so as to generate surface elastic wave. The fluid path is formed on the piezoelectric film.
Abstract translation: 提供了一种微流体输送装置及其制造方法，其通过使用基于有机硅的商业化的半导体制造技术以低成本进行批量生产。 微流体输送装置包括基底（101），压电薄膜（102），IDT（Inter Digitated Transducer）电极和流体通路。 压电膜形成在基板的上部。 用于能量转换的IDT电极形成在压电膜上，以产生表面弹性波。 流体路径形成在压电膜上。
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