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    PRECISELY-SHAPED POROUS PARTICLES
    31.
    发明申请
    PRECISELY-SHAPED POROUS PARTICLES 审中-公开
    精细形状的多孔颗粒

    公开(公告)号：WO2009085424A1

    公开(公告)日：2009-07-09

    申请号：PCT/US2008/083737

    申请日：2008-11-17

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  WICKERT, Peter D. ,  CULLER, Scott R. ,  RASMUSSEN, Jerald K.

    Inventor： WICKERT, Peter D. ,  CULLER, Scott R. ,  RASMUSSEN, Jerald K.

    IPC: C01B33/14 ,  C01B33/141

    CPC classification number: B29C39/148 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28054 ,  B01J20/28059 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3007 ,  B01J20/3242 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/259 ,  Y10T428/2982

    Abstract: Precisely-shaped composites and methods for making these composites are disclosed. The method of this disclosure comprises introducing a precursor composition onto a production tool having at least one continuous surface and a plurality of cavities so as to fill at least a portion of the cavities with the precursor composition and wherein the precursor composition, upon curing, forms a composition having a shape corresponding to the cavities thereby resulting in a plurality of discrete, precisely-shaped particles having a porosity comprising one of the following: (a) 10 m 2 /g or greater or (b) 5 kdalton or greater. The precisely-shaped particles have at least one essentially flat side. The precisely-shaped particles can be confined in a vessel and used for chromatographic applications.

    Abstract translation: 公开了精确形状的复合材料和制备这些复合材料的方法。 本公开的方法包括将前体组合物引入到具有至少一个连续表面和多个空腔的生产工具上，以便用前体组合物填充至少一部分空腔，并且其中前体组合物在固化时形成 具有与空腔相对应的形状的组合物，从而导致多个离散的精确成形的颗粒，其具有包括以下之一的孔隙率：（a）10m 2 / g或更大或（b）5kdalton或更大。 精确形状的颗粒具有至少一个基本平坦的侧面。 精确形状的颗粒可以限制在容器中并用于色谱应用。

    METHOD OF PROCESSING POLYNUCLEIC ACIDS
    33.
    发明申请
    METHOD OF PROCESSING POLYNUCLEIC ACIDS 审中-公开

    公开(公告)号：WO2023084369A1

    公开(公告)日：2023-05-19

    申请号：PCT/IB2022/060640

    申请日：2022-11-04

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： WATTS, Annabelle ,  BONILLA, Tonya D. ,  RASMUSSEN, Jerald K. ,  FISHMAN, Joshua M. ,  TRAEGER, Lindsay L. ,  COLAK ATAN, Semra

    IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6813

    Abstract: A method of processing polynucleic acids is described comprising: providing a solid support comprising ligands with an amide group; exposing the solid support to polynucleic acid molecules in a buffer having a pH less than 5.5 to bind at least a portion of the polynucleic acid molecules to the ligands; c) exposing the solid support (e.g. particles) with bound polynucleic acid molecules to a buffer having a pH greater than 6 to release a portion of the bound polynucleic acid molecules from the ligands of the particles and to retain a portion of the polynucleic acid molecules bound to the solid support (e.g. particles); and utilizing the solid support with retained bound polynucleic acid molecules or suspension thereof.

    METHOD FOR BIOMATERIAL PURIFICATION AND KITS THEREOF
    35.
    发明申请
    METHOD FOR BIOMATERIAL PURIFICATION AND KITS THEREOF 审中-公开

    公开(公告)号：WO2021105864A1

    公开(公告)日：2021-06-03

    申请号：PCT/IB2020/061072

    申请日：2020-11-24

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： RICHARDSON, Kristopher E. ,  O'NEAL, Daniel J. ,  RASMUSSEN, Jerald K. ,  VAIL, Andrew W.

    IPC: C07K1/32 ,  C07K1/34

    Abstract: Described herein is a method of purifying a target molecule from an aqueous biological composition, the method comprising: (a) contacting a cationic polymer and the aqueous biological composition to form a mixture comprising a bio-polymer complex and the target molecule in a liquid, wherein the bio-polymer complex has an average particle diameter of at least 45 micrometers, (b) adding the mixture to a filtering volume of a vessel, wherein the vessel comprises loosely packed staple fibers; (c) allowing the mixture to separate through the loosely packed staple fiber; and (d) collecting a filtrate comprising the target molecule.

    BIOTIN-CONTAINING MONOMERS AND ARTICLES FORMED THEREFROM
    36.
    发明申请
    BIOTIN-CONTAINING MONOMERS AND ARTICLES FORMED THEREFROM 审中-公开

    公开(公告)号：WO2021105843A1

    公开(公告)日：2021-06-03

    申请号：PCT/IB2020/061018

    申请日：2020-11-23

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： RASMUSSEN, Jerald K.

    IPC: C08F220/54 ,  C09D4/00 ,  C09D133/24

    Abstract: Biotin-containing monomers, polymeric materials formed from the biotin-containing monomers, articles containing the polymeric materials, methods of making the articles, and methods of using the articles are provided. The articles can be used, for example, for affinity capture of biotin-binding proteins, including biotin-binding fusion proteins (i.e., a biotin-binding protein fused to another biomaterial). Articles that contain captured biotin-binding proteins can be further used for affinity capture of various biotin-containing biomaterials such as biotinylated proteins. The articles can also be used, for example, for affinity capture of biotin-binding fusion proteins where the fusion protein includes, for example, an enzyme or antibody.

    PROCESSES FOR SEPARATING AGGREGATED PROTEINS FROM MONOMERIC PROTEINS IN A BIOLOGICAL SOLUTION
    37.
    发明申请
    PROCESSES FOR SEPARATING AGGREGATED PROTEINS FROM MONOMERIC PROTEINS IN A BIOLOGICAL SOLUTION 审中-公开
    在生物溶液中从单体蛋白中分离聚集蛋白的过程

    公开(公告)号：WO2018048698A1

    公开(公告)日：2018-03-15

    申请号：PCT/US2017/049376

    申请日：2017-08-30

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： COLAK ATAN, Semra ,  VAIL, Andrew W. ,  RASMUSSEN, Jerald K. ,  GRIESGRABER, George W. ,  BOTHOF, Catherine A.

    IPC: C07K1/18 ,  C07K1/34

    CPC classification number: C07K1/34 ,  B01D71/40 ,  C07K1/18 ,  C07K16/00

    Abstract: A process for separating aggregated proteins from monomeric proteins in a biological solution, the process including: providing at least one filter element having a contacting surface, wherein the filter element comprises filter media comprising: a porous substrate; and disposed on the porous substrate, a polymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein each of a first plurality of pendant groups comprises: (1) at least one acidic group or salt thereof; and (2) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and allowing an initial biological solution to contact the contacting surface of the filter element under conditions effective to separate the aggregated proteins from the monomeric proteins such that a final biological solution includes purified monomeric proteins.

    Abstract translation: 一种用于从生物溶液中的单体蛋白中分离聚集蛋白的方法，所述方法包括：提供至少一个具有接触表面的过滤元件，其中所述过滤元件包含过滤介质，所述过滤介质包含：多孔基材; 并且设置在所述多孔基材上的聚合物，所述聚合物包含烃骨架和连接至所述烃骨架的多个侧基，其中第一多个侧基中的每一个包含：（1）至少一种酸性基团或其盐; 和（2）通过至少6个连接原子的链将所述至少一个酸性基团或其盐直接连接到烃主链上的间隔基团; 并且在有效将聚集蛋白与单体蛋白分离的条件下使初始生物溶液与过滤元件的接触表面接触，使得最终生物溶液包括纯化的单体蛋白。

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