公开(公告)号：CA2253330A1

公开(公告)日：1997-11-13

申请号：CA2253330

申请日：1997-05-06

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  MA ZHENKUN ,  CLARK RICHARD F ,  LI LEPING ,  GRIESGRABER GEORGE ,  CHU DANIEL T

IPC: C07H17/08 ,  A61K31/70 ,  C07H23/00

Abstract: Antimicrobial compounds having formula (II), (III), (IV), (V), (VI), (VII), (VIII) and (IX); as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

公开(公告)号：CA2564377C

公开(公告)日：2009-08-11

申请号：CA2564377

申请日：1997-09-02

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE ,  CHU DANIEL T ,  CLARK RICHARD F ,  PLATTNER JACOB J ,  MA ZHENKUN

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07D498/14

Abstract: Antimicrobial compounds having formula (IV) or (IVA) as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutica l compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation o f the compounds. (see formula IV) or (see formula IVA)

公开(公告)号：HU0004323A2

公开(公告)日：2001-02-28

申请号：HU0004323

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  GRIESGRABER GEORGE ,  LI LEPING ,  OR YAT SUN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

公开(公告)号：SK6342000A3

公开(公告)日：2000-09-12

申请号：SK6342000

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H17/00 ,  A61K31/70

Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

公开(公告)号：NZ332320A

公开(公告)日：2000-07-28

申请号：NZ33232097

申请日：1997-05-06

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

IPC: C07H17/08 ,  A61K31/70

Abstract: The erythromycin derivative has one of the formulae II to IX or a pharmaceutically acceptable salt, ester or prodrug thereof wherein: X is =O, =NOH, =NOR1 or =NOC(R5)(R6)-O-R1; Ra and Rb are independently H or OH; one of Rc and Rd is H and the other is OH, protected OH, halogen, NR6R7, OCO-NH-aryl, O-CO-NH-heteroaryl, O-CO-NR7R8, O-SO2-(optionally substituted alkyl) or O-SO2-(CH2)2-NR7R8 or together form =O, =NOH or =NOR1; R3 is methoxy, F or OH; Rf is H or a hydroxy protecting group; W is absent, O, NH-CO, N=CH or NH; Rg is H, cycloalkyl or optionally substituted alkyl, aryl or heteroaryl; Rh is H, OH, O-C(O)-imidazolyl, O-C(O)-O-alkyl, O-C(O)-O-(optionally substituted aryl), O-C(O)-Cl or O-C(O)-NH2; R is substituted methyl or optionally substituted C2-10 alkyl, C3-10 alkenyl or C3-10 alkynyl; one of Y and Z is hydrogen and the other is H, OH, protected OH or NR7R8; A, B, D and E are independently H, cycloalkyl or optionally substituted alkyl, aryl or heteroaryl, heterocycloalkyl or is optionally substituted aryl, heteroaryl, OH, alkoxy, halo or NR9R10 further substituted with MR11 or any of AB, AD, AE, BD, BE or DE together with the atoms to which they are attached form a 3-7 membered ring optionally containing O, NR', S(O)n, C(O)-NH, C(O)-NR12, NH-C(O), NR12-C(O)- or C(=NH)-NH provided that at least two of A, B, D and E are hydrogen and the rest of the variables are defined in the specification. A pharmaceutical composition thereof is useful for treating bacterial infections.

公开(公告)号：CA2564020A1

公开(公告)日：1998-03-12

申请号：CA2564020

申请日：1997-09-02

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  MA ZHENKUN ,  PLATTNER JACOB J ,  GRIESGRABER GEORGE ,  CLARK RICHARD F ,  CHU DANIEL T

IPC: C07D407/12 ,  C07D405/14

公开(公告)号：ZA973894B

公开(公告)日：1998-02-23

申请号：ZA973894

申请日：1997-05-06

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07D ,  A61K

Abstract: Antimicrobial compounds having the formula as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.