公开(公告)号：CA2416955A1

公开(公告)日：2002-03-07

申请号：CA2416955

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： SPIWEK HARRY O ,  PATEL KETAN M ,  CHEMBURKAR SANJAY R

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S - (1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：BG105197A

公开(公告)日：2001-10-31

申请号：BG10519701

申请日：2001-01-30

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  A61K31/425

Abstract: The invention relates to a new polymorph for of ritonavir, called form II, as well as to methods for its preparation and application. 30 claims, 10 figures

公开(公告)号：CA2674800A1

公开(公告)日：2000-01-27

申请号：CA2674800

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： SPIWEK HARRY O ,  CHEMBURKAR SANJAY R ,  SALEKI-GERHARDT AZITA ,  BAUER JOHN F ,  PATEL KETAN

IPC: A61K31/427 ,  A61K9/08 ,  A61K31/426 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：HU227540B1

公开(公告)日：2011-08-29

申请号：HU0103823

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：CA2416955C

公开(公告)日：2011-04-26

申请号：CA2416955

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：SI1418174T1

公开(公告)日：2009-08-31

申请号：SI9931030

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O

IPC: C07D277/00 ,  A61K31/00 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

公开(公告)号：DK1313712T3

公开(公告)日：2007-09-10

申请号：DK01966367

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  SPIWEK HARRY O ,  PATEL KETAN M

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：DE60128367D1

公开(公告)日：2007-06-21

申请号：DE60128367

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：NO318385B1

公开(公告)日：2005-03-14

申请号：NO20010298

申请日：2001-01-18

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：BR0108146A

公开(公告)日：2004-01-06

申请号：BR0108146

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00 ,  C07D239/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.