公开(公告)号：JP2010270135A

公开(公告)日：2010-12-02

申请号：JP2010164769

申请日：2010-07-22

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: C07D277/28 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

CPC classification number: C07D277/28

Abstract: PROBLEM TO BE SOLVED: To provide a novel crystalline polymorphous form of ritonavir and a process for producing the same.
SOLUTION: There is provided a substantially pure crystalline polymorphous form of (2S, 3S, 5S)-5-(N-(N-((N-methyl-N-((2-isopropyl-4-thiazoyl)methyl)amino)carbonyl)-L-valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane which gives peaks of 2θ angle at 8.67°±0.1°, 9.88°±0.1°, 16.11°±0.1°, 16.70°±0.1°, 17.36°±0.1°, 17.78°±0.1°, 18.40°±0.1°, 18.93°±0.1°, 20.07°±0.1°, 20.65°±0.1°, 21.71°±0.1° and 25.38°±0.1° in a powder X-ray diffraction pattern. There is also provided a process for producing the crystalline polymorph form, which includes inoculating seed crystals in a solution of ritonavir, and then adding an anti-solvent.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供新型的晶体多晶形式的利托那韦及其制备方法。 提供了（2S，3S，5S）-5-（N-（N - （（N-甲基-N - （（2-异丙基-4-噻唑基）甲基） ）氨基）羰基）-L-缬氨酰基）氨基）-2-（N - （（5-噻唑基）甲氧基羰基）氨基）-1,6-二苯基-3-羟基己烷，其在8.67°±0.1°处产生2θ角的峰 ，9.88°±0.1°，16.11°±0.1°，16.70°±0.1°，17.36°±0.1°，17.78°±0.1°，18.40°±0.1°，18.93°±0.1°，20.07°±0.1°，20.65° 在粉末X射线衍射图中为±0.1°，21.71°±0.1°和25.38°±0.1°。 还提供了一种制备结晶多晶型形式的方法，其包括将晶种接种在利托那韦的溶液中，然后加入抗溶剂。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：WO2004037769A3

公开(公告)日：2004-06-17

申请号：PCT/US0333527

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： BENNANI YOUSSEF L ,  CHAMBERLIN STEVE A ,  CHEMBURKAR SANJAY R ,  CHEN JINHUA ,  DART MICHAEL J ,  GUPTA ASHOK K ,  WANG LEI

IPC: A61K31/16 ,  A61K31/33 ,  A61K31/397 ,  A61K31/54 ,  A61K31/55 ,  A61P25/06 ,  A61P25/08 ,  C07C233/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C237/22 ,  C07D233/24

CPC classification number: A61K31/16 ,  A61K31/33 ,  A61K31/397 ,  A61K31/54 ,  A61K31/55 ,  C07C233/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  C07C237/22 ,  C07C2601/14 ,  C07D233/24

Abstract: The present invention relates to the use of compounds of formula (I)for the treatment of a variety of disorders including, bu t not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.

Abstract translation: 本发明涉及式（I）化合物用于治疗各种疾病的用途，所述疾病包括但不限于癫痫，双相情感障碍，精神疾病，偏头痛，疼痛，神经保护和运动障碍。

公开(公告)号：WO0004016A3

公开(公告)日：2000-03-30

申请号：PCT/US9916334

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12 ,  A61K31/425

CPC classification number: C07D277/28

Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.

Abstract translation: 公开了利托那韦的新结晶多晶型物及其使用和制备方法。

公开(公告)号：WO0218349A3

公开(公告)日：2002-05-10

申请号：PCT/US0126898

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00

CPC classification number: C07D239/10 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D403/06

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

Abstract translation: 本发明提供用于合成（（2S，3S，5S）-2-（2,6-二甲基苯氧基乙酰基） - 氨基-3-羟基-5-（2S-（1-四氢嘧啶-2-基） ）-3-甲基 - 丁酰基）氨基-1,6-二苯基己烷及其类似物。

公开(公告)号：CA2731273C

公开(公告)日：2013-10-15

申请号：CA2731273

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: A61K31/513 ,  A61P31/18 ,  C07B53/00 ,  C07D239/10 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1- tetrahydropyrimid- 2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：AU2011215616A1

公开(公告)日：2012-09-06

申请号：AU2011215616

申请日：2011-02-14

Applicant: ABBOTT LAB

Inventor： REDDY RAJARATHNAM E ,  CHEMBURKAR SANJAY R ,  SPAULDING DOUGLAS R ,  PAN YI ,  CAO LEI ,  RESTITUYO JOSE A ,  LORENZINI RICHARD ,  DEMARCO MICHAEL

IPC: C07C35/16 ,  C07H1/06

Abstract: This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting -Inositol to -Inositol using a bioconversion process.

公开(公告)号：SK287381B6

公开(公告)日：2010-08-09

申请号：SK50292008

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  PATEL KETAN ,  SPIWEK HARRY O ,  BAUER PHILIP E ,  ALLEN KIMBERLY A

IPC: A61K31/00 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/00 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: Amorphous ritonavir containing no more than 10 % of any other form of ritonavir characterised by the DSC thermogram recorded at a heating rate of 5 °C/min. and a glass transition temperature from about 45 °C to about 49 °C. Described is also a method for the preparation of amorphous ritonavir and its use.

公开(公告)号：DK1418174T3

公开(公告)日：2009-05-18

申请号：DK03029709

申请日：1999-07-19

Applicant: ABBOTT LAB

Inventor： BAUER JOHN F ,  SALEKI-GERHARDT AZITA ,  PATEL KETAN ,  CHEMBURKAR SANJAY R ,  SPIWEK HARRY O

IPC: C07D277/24 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61P31/18 ,  A61P37/04 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

Abstract: This Application concerns the use of Form II crystalline ritonavir as a pharmaceutical agent, as well as methods of preparing pharmaceutical compositions, which methods employ Form II crystalline ritonavir. The Application further concerns methods for obtaining Form I crystalline ritonavir, which methods employ Form II crystalline ritonavir.

公开(公告)号：DE60128367T2

公开(公告)日：2008-01-10

申请号：DE60128367

申请日：2001-08-29

Applicant: ABBOTT LAB

Inventor： CHEMBURKAR SANJAY R ,  PATEL KETAN M ,  SPIWEK HARRY O

IPC: C07D239/10 ,  C07B53/00 ,  C07D403/06 ,  C07D521/00

Abstract: The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6-diphenylhexane and analogs thereof.

公开(公告)号：AU2007202943A1

公开(公告)日：2007-07-19

申请号：AU2007202943

申请日：2007-06-26

Applicant: ABBOTT LAB

Inventor： BAUER PHILIP E ,  ALLEN KIMBERLY A ,  NARAYANAN BIKSHANDARKOIL A ,  CHEMBURKAR SANJAY R ,  SALEKI-GERHARDT AZITA ,  SPIWEK HARRY O ,  BAUER JOHN F ,  PATEL KETAN

IPC: C07D417/00