公开(公告)号：EP0920428A1

公开(公告)日：1999-06-09

申请号：EP97932584.0

申请日：1997-07-14

Applicant: Abbott Laboratories

Inventor： BROOKS, Clint, D., W. ,  KOLASA, Teodozyj ,  GUNN, David, E.

IPC: A61K31 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D215 ,  C07D401 ,  C07D413 ,  C07D417

CPC classification number: C07D401/12 ,  C07D215/14 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein W and Y are independently selected from the group consisting of (a) quinolyl; (b) quinolyl substituted with a substituent selected from the group consisting of (b-1) halogen, (b-2) alkyl of one to six carbon atoms, (b-3) haloalkyl of one to six carbon atoms, and (b-4) alkoxy of one to six carbon atoms; (c) benzothiazolyl; (d) benzothiazolyl substituted with a substituent selected from the group consisting of (d-1) halogen, (d-2) alkyl of one to six carbon atoms, (d-3) haloalkyl of one to six carbon atoms, and (d-4) alkoxy of one to six carbon atoms; (e) benzoxazolyl; (f) benzoxazolyl substituted with a substituent selected from the group consisting of (f-1) halogen, (f-2) alkyl of one to six carbon atoms; (g) benzimidazolyl; (h) benzimidazolyl substituted with a substituent selected from the group consisting of (h-1) halogen, (h-2) alkyl of one to six carbon atoms; (i) quinoxalyl; (j) quinoxalyl substituted with a substituent selected from the group consisting of (j-1) halogen, (j-2) alkyl of one to six carbon atoms; (k) naphthyl; (l) naphthyl substituted with a substituent selected from the group consisting of (l-1) halogen, (1-2) alkyl of one to six carbon atoms, (1-3) alkoxy of one to six carbon atoms; with the proviso that W and Y are not simultaneously the same substituent; R?1 and R2¿ are independently selected from the group consisting of (a) hydrogen, (b) alkyl of one to six carbon atoms, (c) haloalkyl of one to six carbon atoms, (d) alkoxy of one to six carbon atoms, and (e) halogen; R3 is selected from the group consisting of (a) hydrogen and (b) alkyl of one to six carbon atoms; X is absent or is selected from the group consisting of (a) alkylene of one to six carbon atoms, (b) alkenylene of one to six carbon atoms, and (c) alkynylene of one to six carbon atoms; and M is selected from the group consisting of (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR4 where R4 is selected from the group consisting of hydrogen and alkyl of one to six carbon atoms, (c) -NR5R6 where R?5 and R6¿ are independently selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, hydroxy, and alkoxy of one to six carbon atoms. These compounds inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.

公开(公告)号：EP0772594A1

公开(公告)日：1997-05-14

申请号：EP95926167.0

申请日：1995-06-28

Applicant: Abbott Laboratories

Inventor： BROOKS, Dee, W. ,  BHATIA, Pramila ,  KOLASA, Teodozyj ,  STEWART, Andrew, O.

IPC: A61K31 ,  A61P11 ,  A61P17 ,  A61P19 ,  A61P27 ,  A61P43 ,  C07D213 ,  C07D215 ,  C07D235 ,  C07D239 ,  C07D241 ,  C07D263 ,  C07D277 ,  C07D401 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D513

CPC classification number: C07D213/30 ,  C07D215/14 ,  C07D215/227 ,  C07D215/36 ,  C07D235/12 ,  C07D239/26 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D513/04

Abstract: The present invention relates to a compound of the formula: W-X-Q-Y-CH(R1)-O-N=C(R2)-A-COM, or a pharmaceutically acceptable salt thereof wherein W is optionally substituted aryl or heteroaryl; X is a valence bond, or methylene, divalent alkylene, alkenylene, alkynylene or alkyloxy; Q is a valence bond, or -O-, -S-, > NR4 or > NCOR5; Y is optionally substituted phenyl, biphenyl, naphthyl, tetrahydronaphthyl, indolyl, pyridyl, or benzo[b]thienyl, thienyl, thiazolyl, or thiazolylphenyl; R1 is alkyl, cycloalkyl, alkoxyalkyl, aryl or arylalkyl, heteroaryl or heteroarylalkyl; R2 is hydrogen, alkyl or hydroxyalkyl; A is a valence bond or is selected from alkylene, alkenylene, alkynylene, cycloalkylene, phenylene, pyridylene, thienylene and furylene; and M is a pharmaceutically acceptable, metabolically cleavable group, -OR?6, -NR6R7¿, -NH-tetrazoyl, -NH-2-, 3-, or 4-pyridyl, and -NH-2-, 4-, or 5-thiazolyl which inhibit leukotriene biosynthesis and are useful in the treatment of inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting lipoxygenase activity and leukotriene biosynthesis.

公开(公告)号：EP2334646A2

公开(公告)日：2011-06-22

申请号：EP09792591.1

申请日：2009-09-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A
1 , A
5 , R
x , X
4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2146973A2

公开(公告)日：2010-01-27

申请号：EP08745908.7

申请日：2008-04-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael, J. ,  PEDDI, Sridhar ,  PATEL, Meena, V. ,  NELSON, Derek, W. ,  LI, Tongmei ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  PEREZ-MEDRANO, Arturo

IPC: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K31/425 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/5377 ,  C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及其中R 1，R 2，R 3，R 4和L如说明书中所定义的式（I）的含异噻唑亚基的化合物，包含此类化合物的组合物，以及使用此类化合物和组合物治疗病症和病症的方法。

公开(公告)号：EP1124804B1

公开(公告)日：2005-08-24

申请号：EP99953259.1

申请日：1999-10-27

Applicant: ABBOTT LABORATORIES

Inventor： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  MCCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J. ,  COGHLAN, Michael, J. ,  STEWART, Andrew, O.

IPC: C07D237/14 ,  A61K31/50 ,  C07D405/04 ,  C07D409/04

CPC classification number: C07D405/04 ,  C07D237/14 ,  C07D409/04

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：EP1509213A2

公开(公告)日：2005-03-02

申请号：EP03755402.9

申请日：2003-05-19

Applicant: Abbott Laboratories

Inventor： BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  HAKEEM, Ahmed, A. ,  KOLASA, Teodozyj ,  MATULENKO, Mark, A. ,  MORTELL, Kathleen, H. ,  PATEL, Meena, V. ,  STEWART, Andrew, O. ,  WANG, Xueqing ,  XIA, Zhiren ,  ZHANG, Henry, Q.

IPC: A61K31/00

CPC classification number: A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506

Abstract: The present invention relates to the use of compounds of formula (I), for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1483258A1

公开(公告)日：2004-12-08

申请号：EP03716268.2

申请日：2003-03-04

Applicant: Abbott Laboratories

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  PATEL, Meena, V. ,  KOLASA, Teodozyj ,  BRIONI, Jorge, D. ,  ROHDE, Jeffrey ,  ENGSTROM, Kenneth, M.

IPC: C07D401/12 ,  C07D417/12 ,  C07D235/14 ,  C07D401/14 ,  C07D403/12 ,  A61K31/505

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D403/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1102754A1

公开(公告)日：2001-05-30

申请号：EP99939019.8

申请日：1999-08-06

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  MEYER, Michael, D. ,  KERWIN, James, F., Jr. ,  HOLLADAY, Mark, W. ,  KHILEVICH, Albert ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey ,  CARROLL, William, A.

IPC: C07D233/61 ,  A61K31/4164 ,  C07D405/04 ,  C07D413/12 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D405/12 ,  C07D277/28 ,  C07D263/32 ,  C07D263/48 ,  C07D277/40

CPC classification number: C07D233/64 ,  C07D233/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.

公开(公告)号：EP2331516B1

公开(公告)日：2013-03-13

申请号：EP09791365.1

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

公开(公告)号：EP2344463A2

公开(公告)日：2011-07-20

申请号：EP09752053.0

申请日：2009-11-04

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek, W. ,  PATEL, Meena, V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  WANG, Xuequing

IPC: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.