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    32.
    发明专利
    未知

    公开(公告)号：AT520984T

    公开(公告)日：2011-09-15

    申请号：AT06758550

    申请日：2006-04-20

    Applicant: AMNIS CORP

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  LYNCH DAVID

    IPC: G01N33/53

    Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

    Method and apparatus for labeling and analyzing cellular components
    34.
    发明专利
    Method and apparatus for labeling and analyzing cellular components 未知

    公开(公告)号：AU2002324422A1

    公开(公告)日：2002-12-23

    申请号：AU2002324422

    申请日：2002-02-21

    Applicant: AMNIS CORP

    Inventor： BASIJI DAVID ,  ORTYN WILLIAM

    IPC: C12Q1/68 ,  C12Q1/6841 ,  G01N27/447 ,  C07H21/04 ,  C12M1/34

    Abstract: A labeling method that labels an object or specific features of an object with labeled probes that provide a multiplexed signal that can be analyzed by spectral decomposition. This binary and higher encoding scheme can be employed to label components of biological cells. In each encoding scheme, labeled probes that selectively bind to a specific feature are required. The labeled probes include a binding element that binds to the feature, and at least one signaling component that generates a detectable signal, preferably a spectral signature. In one embodiment, adding multiple fluorescent dye molecules to each binding element provides the multiplexed signal. In another embodiment, adding only one signal compound to each binding element provides the multiplexed signal, such that some of the binding elements have a different signal compound added. The different signal compounds provide the multiplexed signal.

    Methods for synthesizing reporter labeled beads
    35.
    发明专利
    Methods for synthesizing reporter labeled beads 未知

    公开(公告)号：AU1189902A

    公开(公告)日：2002-04-22

    申请号：AU1189902

    申请日：2001-10-12

    Applicant: AMNIS CORP

    Inventor： BASIJI DAVID ,  ORTYN WILLIAM

    IPC: C07B61/00 ,  C07K1/04 ,  C12Q1/68 ,  G01N15/02 ,  G01N15/14 ,  G01N21/05 ,  G02B7/28 ,  G02B21/00 ,  G01N33/53

    Abstract: Methods for constructing reporter labeled carriers (such as beads) using a plurality of optically distinguishable carriers for chemical synthesis or attachment, such that the number of unique reporters required to label a carrier is reduced. One embodiment employs carriers that themselves have optically distinguishing characteristics. A carrier's identity is encoded by the combination of the optical characteristics of its reporter set, as well as the optical characteristics of the carrier itself. In other embodiments, different reporters are discriminable based on the intensity of their color labels, their size, and/or other optically detectable characteristics, and not necessarily by the presence or absence of particular colors. Another embodiment is directed to generating a plurality of reporters from a plurality of singly labeled micro-particles. The present invention can be employed in conjunction with a split/add/pool (SAP) or a directed synthesis process.

    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER
    37.
    发明公开
    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER 审中-公开
    用流式细胞计数仪进行血液分析

    公开(公告)号：EP1844426A4

    公开(公告)日：2016-09-07

    申请号：EP06720094

    申请日：2006-02-01

    Applicant: AMNIS CORP

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    IPC: G06K9/00

    CPC classification number: G06K9/00127 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1497

    Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

    METHODS FOR ANALYZING INTER-CELLULAR PHENOMENA
    38.
    发明公开
    METHODS FOR ANALYZING INTER-CELLULAR PHENOMENA 有权
    VERFAHREN ZUR ANALYZEINTERZELLULÄERPHANOMENE

    公开(公告)号：EP1886139A4

    公开(公告)日：2008-07-16

    申请号：EP06758550

    申请日：2006-04-20

    Applicant: AMNIS CORP

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  LYNCH DAVID

    IPC: G01N33/53

    CPC classification number: G01N33/505 ,  G01J3/2889 ,  G01J3/36 ,  G01J3/4406 ,  G01N15/1429 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/53 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/5005 ,  G01N2015/1006 ,  G01N2015/1497 ,  G01N2021/6421 ,  G01N2021/6441 ,  G06K9/00127

    Abstract: Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least one characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study, the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.

    Abstract translation: 本发明的各方面包括从物体群收集多光谱图像，并且采集所收集图像的分析以使用图像集合中可识别的光度和/或形态学特征来测量群体的至少一个特征。 在示例性应用中，物体是生物细胞。 在特别优选的但非限制性的实现中，同时收集每个单独对象的多个图像。 在实证研究中，被测量的特征涉及共轭细胞之间的突触。 结合的细胞可以代表成像的整个对象群体的亚群。 在一个特别优选的但非限制性的实施方案中，本发明能够量化由于不同生物细胞的缀合而导致的细胞分子的重新分布。 重要的是，这种量化不适用于标准显微镜和流式细胞术。

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