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    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS
    1.
    发明申请
    EXTENDED DEPTH OF FIELD IMAGING FOR HIGH SPEED OBJECT ANALYSIS 审中-公开
    用于高速物体分析的现场成像的扩展深度

    公开(公告)号：WO2007067999A3

    公开(公告)日：2007-11-29

    申请号：PCT/US2006061871

    申请日：2006-12-11

    Applicant: AMNIS CORP ,  ORTYN WILLIAM ,  BASIJI DAVID ,  FROST KEITH ,  LIANG LUCHUAN ,  BAUER RICHARD ,  HALL BRIAN ,  PERRY DAVID

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  FROST KEITH ,  LIANG LUCHUAN ,  BAUER RICHARD ,  HALL BRIAN ,  PERRY DAVID

    IPC: G02F1/01

    CPC classification number: G02B27/0075 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6458 ,  G01N2015/1452 ,  G02B21/365 ,  G02B27/0012

    Abstract: A high speed, high-resolution flow imaging system is modified to achieve extended depth of field imaging. An optical distortion element is introduced into the flow imaging system. Light from an object, such as a cell, is distorted by the distortion element, such that a point spread function (PSF) of the imaging system is invariant across an extended depth of field. The distorted light is spectrally dispersed, and the dispersed light is used to simultaneously generate a plurality of images. The images are detected, and image processing is used to enhance the detected images by compensating for the distortion, to achieve extended depth of field images of the object. The post image processing preferably involves de-convolution, and requires knowledge of the PSF of the imaging system, as modified by the optical distortion element.

    Abstract translation: 改进了高速，高分辨率流动成像系统，以实现扩展的景深成像。 光学失真元件被引入到流动成像系统中。 来自诸如单元的物体的光被失真元件扭曲，使得成像系统的点扩散函数（PSF）在扩展的景深范围内是不变的。 失真光被光谱分散，并且分散的光被用于同时产生多个图像。 检测图像，并且使用图像处理来通过补偿失真来增强检测到的图像，以实现对象的扩展景深图像。 后图像处理优选地涉及去卷积，并且需要由光学失真元件修改的成像系统的PSF的知识。

    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER
    2.
    发明申请
    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER 审中-公开
    使用流量成像测量仪进行血液分析

    公开(公告)号：WO2006083969A3

    公开(公告)日：2008-06-26

    申请号：PCT/US2006003573

    申请日：2006-02-01

    Applicant: AMNIS CORP ,  ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    IPC: G06K9/00

    CPC classification number: G06K9/00127 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1497

    Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected (402). Photometric and/or morphometric features identifiable in the images (404) are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation (408). Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

    Abstract translation: 同时收集细胞群的多峰/多光谱图像（402）。 图像（404）中可识别的光度和/或形态测量特征用于将细胞群分离成多个亚群体。 当细胞群体包括患病细胞和健康细胞时，图像可被分成健康亚群和患病亚群（408）。 在细胞群不包括患病细胞的情况下，不具有疾病状况的患者中不同细胞类型的一种或多种比例可以与具有疾病状况的患者中的相应比例进行比较，从而能够检测疾病状况。 例如，血细胞可以基于它们的图像分离成不同类型，并且可以容易地检测淋巴细胞数量的增加，这是与慢性淋巴细胞性白血病相关的现象。

    AUTO FOCUS FOR A FLOW IMAGING SYSTEM
    3.
    发明申请
    AUTO FOCUS FOR A FLOW IMAGING SYSTEM 审中-公开
    自动聚焦流动成像系统

    公开(公告)号：WO2004092781A3

    公开(公告)日：2005-05-06

    申请号：PCT/US2004011030

    申请日：2004-04-09

    Applicant: AMNIS CORP ,  ORTYN WILLIAM ,  SEO MICHAEL ,  BASIJI DAVID ,  FROST KEITH ,  PERRY DAVID

    Inventor： ORTYN WILLIAM ,  SEO MICHAEL ,  BASIJI DAVID ,  FROST KEITH ,  PERRY DAVID

    IPC: G01N15/14 ,  G02B27/40

    CPC classification number: G01N15/147 ,  G01N2015/1075 ,  G01N2015/1452

    Abstract: A pair of optical gratings (126, 134) are used to modulate light from an object (102), and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens (110) should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.

    Abstract translation: 一对光栅（126,134）用于调制来自物体（102）的光，并且来自任一光学的调制光用于确定物体的速度。 每个光栅从参考焦点偏移相同的距离，一个光栅在正方向上偏移，另一个光栅在负方向上偏移。 可以处理响应于调制光产生的信号以确定主收集透镜（110）应该移动的方向，以便改善成像系统对物体的焦点。 透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。 在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER
    5.
    发明公开
    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER 审中-公开
    用流式细胞计数仪进行血液分析

    公开(公告)号：EP1844426A4

    公开(公告)日：2016-09-07

    申请号：EP06720094

    申请日：2006-02-01

    Applicant: AMNIS CORP

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    IPC: G06K9/00

    CPC classification number: G06K9/00127 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1497

    Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

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