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公开(公告)号：AT539064T
公开(公告)日：2012-01-15
申请号：AT06836069
申请日：2006-05-17
Applicant: ARRAY BIOPHARMA INC
Inventor： MARLOW ALLISON , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH , YANG HONG , BLAKE JIM , STOREY RICHARD , BOOTH REBECCA , PITTAM JOHN , LEONARD JOHN , FIELDING MARK
IPC: C07D237/24 , A61K31/501 , A61P35/00 , C07D213/80 , C07D213/82 , C07D213/85
Abstract: This invention relates to a series of novel heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：AT524443T
公开(公告)日：2011-09-15
申请号：AT04811726
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , YANG HONG , LYSSIKATOS JOSEPH
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：AT495155T
公开(公告)日：2011-01-15
申请号：AT04811727
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： MARLOW ALLISON , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH , YANG HONG , BLAKE JIM
IPC: C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：AU2004293019B2
公开(公告)日：2010-10-28
申请号：AU2004293019
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , BLAKE JIM , YANG HONG WOON
IPC: A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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公开(公告)号：AU2004293017B2
公开(公告)日：2010-08-19
申请号：AU2004293017
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： LYSSIKATOS JOSEPH P , WALLACE ELI , YANG HONG WOON
IPC: C07D209/44 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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Patent Agency Ranking
公开(公告)号：CA2535614C
公开(公告)日：2009-12-22
申请号：CA2535614
申请日：2004-08-10
Applicant: ARRAY BIOPHARMA INC
Inventor： BUCKMELTER ALEXANDRE , ZHAO QIAN , TOPALOV GEORGE , WALLACE ELI , LYSSIKATOS JOSEPH
IPC: C07D413/14 , A61K31/517 , A61P35/00 , C07D239/94 , C07D401/12 , C07D413/12 , C07D417/14 , C07D498/02 , C07D498/04 , C07D498/08
Abstract: This invention provides quinazoline analogs of Formula (I): where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula (I) as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：AU2003291394B2
公开(公告)日：2009-06-25
申请号：AU2003291394
申请日：2003-11-10
Applicant: ARRAY BIOPHARMA INC
Inventor： TOPALOV GEORGE , LYSSIKATOS JOSEPH P , WALLACE ELI , ZHAO QIAN
IPC: C07D239/94 , A61P31/18 , A61P35/00 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14
Abstract: Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Use of the compounds of the invention to manufacture therapeutic compositions for the treatment of hyperproliferative diseases in mammals is also disclosed.
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公开(公告)号：HK1121140A1
公开(公告)日：2009-04-17
申请号：HK08112819
申请日：2008-11-21
Applicant: ARRAY BIOPHARMA INC , ASTRAZENECA AB
Inventor： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: A61K20060101 , A61P20060101 , C07D20060101
Abstract: This invention relates to a series of novel heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：AU2006299902A1
公开(公告)日：2007-04-19
申请号：AU2006299902
申请日：2006-05-17
Applicant: ASTRAZENECA AB , ARRAY BIOPHARMA INC
Inventor： FIELDING MARK RICHARD , BOOTH REBECCA JANE , YANG HONG WOON , WALLACE ELI , STOREY RICHARD ANTHONY , MARLOW ALLISON L , LEONARD JOHN , PITTAM JOHN DAVID , BLAKE JIM , LYSSIKATOS JOSEPH P , SEO JEONGBEOB
IPC: C07D213/84 , A61K31/44 , C07D213/63
Abstract: This invention relates to a series of novel heterocyclic compounds that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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公开(公告)号：AU2004293018A1
公开(公告)日：2005-06-09
申请号：AU2004293018
申请日：2004-11-18
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JIM , MARLOW ALLISON L , LYSSIKATOS JOSEPH P , WALLACE ELI , SEO JEONGBEOB , YANG HONG WOON
IPC: A01N43/42 , A01N33/02 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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