公开(公告)号：EP0667855B1

公开(公告)日：1999-03-24

申请号：EP94902209.9

申请日：1993-11-05

Applicant: ABBOTT LABORATORIES

Inventor： BASHA, Anwer ,  BHATIA, Pramila ,  BROOKS, Dee, W. ,  CRAIG, Richard, A. ,  RATAJCZYK, James, D. ,  STEWART, Andrew, O.

IPC: C07C275/20 ,  A61K31/17 ,  C07C275/64 ,  C07D307/52

CPC classification number: C07D405/06 ,  C07C275/64 ,  C07D213/61 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D409/06

Abstract: The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.

公开(公告)号：EP0862557A1

公开(公告)日：1998-09-09

申请号：EP96932335.0

申请日：1996-09-25

Applicant: Abbott Laboratories

Inventor： BROOKS, Clint, D., W. ,  BHATIA, Pramila ,  KOLASA, Theodozyj ,  STEWART, Andrew, O. ,  GUNN, David, E. ,  CRAIG, Richard, A.

IPC: C07D239 ,  A61K31 ,  A61P37 ,  A61P43 ,  C07D213 ,  C07D215 ,  C07D235 ,  C07D241 ,  C07D263 ,  C07D277 ,  C07D417

CPC classification number: C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D235/12 ,  C07D241/42 ,  C07D277/64

Abstract: Compounds having formula (I), wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R?1 and R2¿ are independently selected from hydrogen, alkyl, haloalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH¿2?-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR?6¿, (c) -NR7R8, (d) -NR6SO2R9, (e) -NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

公开(公告)号：EP2350002A1

公开(公告)日：2011-08-03

申请号：EP09737258.5

申请日：2009-10-01

Applicant: Abbott Laboratories

Inventor： BHATIA, Pramila, A. ,  DOHERTY, George, A. ,  DRIZIN, Irene ,  MACK, Helmut ,  PERNER, Richard, J. ,  STEWART, Andrew, O. ,  ZHANG, Qing Wei

IPC: C07D211/76 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D207/27 ,  C07D207/48 ,  C07D487/10 ,  A61K31/395 ,  A61P25/04 ,  C07D413/14

CPC classification number: C07D487/10 ,  C07D207/27 ,  C07D207/48 ,  C07D209/52 ,  C07D211/76 ,  C07D211/96 ,  C07D241/08 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar
1 , Ar
2 , L
1 , L
2 , n, R
1 , R
4 , X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1373220B1

公开(公告)日：2007-05-30

申请号：EP02731130.7

申请日：2002-03-06

Applicant: ABBOTT LABORATORIES

Inventor： COWART, Marlon, D. ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  STEWART, Andrew, O. ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey, J. ,  PATEL, Meena, V. ,  BRIONI, Jorge, D.

IPC: C07D235/06 ,  A61P15/10 ,  A61K31/4188

CPC classification number: C07D401/12 ,  C07D235/14 ,  C07D401/14 ,  C07D417/12

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

公开(公告)号：EP1090009A2

公开(公告)日：2001-04-11

申请号：EP99926157.1

申请日：1999-06-03

Applicant: ABBOTT LABORATORIES

Inventor： STEWART, Andrew, O. ,  BOYD, Steven, A. ,  ARENDSEN, David, L. ,  BHATIA, Pramila ,  CONDROSKI, Kevin, R. ,  FREEMAN, Jennifer, C. ,  GUNAWARDANA, Indrani, W. ,  ZHU, Gui-Dong ,  LARTEY, Kraig ,  MCCARTY, Catherine, M. ,  MORT, Nicholas, A. ,  PATEL, Meena V. ,  STAEGER, Michael, A. ,  STOUT, David, M.

IPC: C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D471/04 ,  C07D491/04 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505

CPC classification number: C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）化合物的药物组合物，以及在哺乳动物中抑制/治疗炎性疾病的方法。

公开(公告)号：EP0540673B1

公开(公告)日：1996-10-16

申请号：EP91915194.4

申请日：1991-07-11

Applicant: ABBOTT LABORATORIES

Inventor： BROOKS, Dee, W. ,  STEWART, Andrew, O. ,  KERKMAN, Daniel, J. ,  BHATIA, Pramila, A. ,  BASHA, Anwer ,  MARTIN, Jonathan, G.

IPC: C07C275/64 ,  C07D307/58 ,  C07D333/20 ,  C07D333/58 ,  C07D307/52 ,  C07D213/68 ,  C07D213/64 ,  C07D213/65 ,  C07D307/64 ,  C07D277/34 ,  C07D407/12 ,  C07D405/12 ,  C07D333/32 ,  C07D333/34 ,  C07D213/42 ,  C07D263/58 ,  C07D333/28 ,  C07D409/04 ,  C07D307/81 ,  C07D217/24 ,  C07D215/14 ,  C07D215/22 ,  C07D241/18 ,  C07D239/34 ,  C07D213/69 ,  A61K31/17 ,  A61K31/34 ,  C07C271/40 ,  C07C333/12

CPC classification number: C07D213/40 ,  C07C275/64 ,  C07D213/643 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D215/227 ,  C07D217/24 ,  C07D239/34 ,  C07D241/18 ,  C07D263/56 ,  C07D277/34 ,  C07D307/52 ,  C07D307/56 ,  C07D307/58 ,  C07D307/64 ,  C07D307/81 ,  C07D333/20 ,  C07D333/28 ,  C07D333/32 ,  C07D333/34 ,  C07D333/58 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

Abstract: Compounds of the structure (I) where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or -NR1R2, where R?1 and R2¿ are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzol[b]furyl, thienyl, or benzol[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

公开(公告)号：EP0667855A1

公开(公告)日：1995-08-23

申请号：EP94902209.0

申请日：1993-11-05

Applicant: ABBOTT LABORATORIES

Inventor： BASHA, Anwer ,  BHATIA, Pramila ,  BROOKS, Dee, W. ,  CRAIG, Richard, A. ,  RATAJCZYK, James, D. ,  STEWART, Andrew, O.

IPC: A61K31 ,  A61P9 ,  A61P11 ,  A61P17 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07C273 ,  C07C275 ,  C07D213 ,  C07D277 ,  C07D307 ,  C07D333 ,  C07D405 ,  C07D409 ,  C07D417

CPC classification number: C07D405/06 ,  C07C275/64 ,  C07D213/61 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D409/06

Abstract: The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.