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公开(公告)号：WO2007059230A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/044379
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES , PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent, L. , GANDHI, Viraj, B.
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent, L. , GANDHI, Viraj, B.
IPC: C07D235/18 , C07D409/04 , C07D417/04 , A61K31/4184 , A61P35/00
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：WO2003051366A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/039915
申请日：2002-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LI, Qun , WOODS, Keith, W. , ZHU, Gui-Dong , FISCHER, John, P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439
CPC classification number: C07D401/04 , C07D213/63 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D475/02
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了抑制蛋白激酶的组合物和抑制患者蛋白激酶的方法。
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公开(公告)号：WO2009012280A3
公开(公告)日：2009-01-22
申请号：PCT/US2008/070113
申请日：2008-07-16
Applicant: ABBOTT LABORATORIES , GANDHI, Virajkumar B , GIRANDA, Vincent L , GONG, Jianchun , PENNING, Thomas D , ZHU, Gui-Dong
Inventor： GANDHI, Virajkumar B , GIRANDA, Vincent L , GONG, Jianchun , PENNING, Thomas D , ZHU, Gui-Dong
IPC: C07D417/14 , A61K31/427 , A61P35/00 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
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4.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 审中-公开在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂
公开(公告)号：WO2007041357A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/038169
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES , PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
Abstract translation: 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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5.发明申请
公开(公告)号：WO2003051366A3
公开(公告)日：2003-06-26
申请号：PCT/US2002/039915
申请日：2002-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LI, Qun , WOODS, Keith, W. , ZHU, Gui-Dong , FISCHER, John, P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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Patent Agency Ranking6.发明授权SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1966157B1
公开(公告)日：2010-03-24
申请号：EP06837694.6
申请日：2006-11-15
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , ZHU, Gui-Dong , GONG, Jianchun , GIRANDA, Vincent L. , GANDHI, Viraj B.
IPC: C07D235/18
CPC classification number: C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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7.发明公开3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开3-（苯基烷氧基）-5-（苯基）一种癌的治疗作为激酶抑制剂的吡啶衍生物和相关化合物
公开(公告)号：EP1463505A2
公开(公告)日：2004-10-06
申请号：EP02790126.3
申请日：2002-12-12
Applicant: Abbott Laboratories
Inventor： LI, Qun , WOODS, Keith W. , ZHU, Gui-Dong , FISCHER, John P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14 , C07D401/04 , C07D475/02 , C07D213/63
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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8.发明公开
公开(公告)号：EP1165505A1
公开(公告)日：2002-01-02
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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9.发明授权1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在由苯基的2-位上取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1957477B1
公开(公告)日：2011-12-07
申请号：EP06836157.5
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
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10.发明公开1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在由苯基的2-位上取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1957477A1
公开(公告)日：2008-08-20
申请号：EP06836157.5
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
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