公开(公告)号：AT130872T

公开(公告)日：1995-12-15

申请号：AT91912909

申请日：1991-07-19

Applicant: BASF AG

Inventor： BACH ALFRED ,  HILLEN HEINZ ,  BIALOJAN SIEGFRIED

IPC: A61K38/00 ,  A61K35/76 ,  A61K38/46 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/31 ,  C12N15/57

公开(公告)号：CA2098815A1

公开(公告)日：1992-06-23

申请号：CA2098815

申请日：1991-12-12

Applicant: BASF AG

Inventor： STEINER GERD ,  BACH ALFRED ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: A61K31/55 ,  A61P25/04 ,  A61P25/06

Abstract: 2098815 9211014 PCTABS00014 The description relates to the use of 5-cyanomethylene-4-(piperazone-1-yl)-pyrrolo¢4,3-e!benzoazepines of formula I, in which R1, R2 and R3 have the significance given in the specification, for relieving migraine.

公开(公告)号：CA2004764A1

公开(公告)日：1990-06-10

申请号：CA2004764

申请日：1989-12-06

Applicant: BASF AG

Inventor： BACH ALFRED ,  STRUBE KARL-HERMANN ,  KOERWER WOLFGANG

IPC: A61K38/36 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  A61P13/02 ,  A61P15/00 ,  C07K14/46 ,  C07K14/75 ,  C12N1/00 ,  C12N1/15 ,  C12N1/21 ,  C12N5/22 ,  C12N9/50 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12N15/57 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12R1/19 ,  C12R1/91

Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.

公开(公告)号：AU749539B2

公开(公告)日：2002-06-27

申请号：AU9068398

申请日：1998-07-23

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA FRANCISCO JAVIER ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14

Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.

公开(公告)号：NO312154B1

公开(公告)日：2002-04-02

申请号：NO970164

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12 ,  A61P25/00

Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

公开(公告)号：NO311683B1

公开(公告)日：2002-01-07

申请号：NO970163

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/415 ,  C07D233/84 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18

Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：BG104291A

公开(公告)日：2001-05-31

申请号：BG10429100

申请日：2000-04-03

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: The invention relates to new 3-substituted tetrahydropyridopyrimidinone derivatives with the formula where the substituents have the meanings given in the Description, to methods for producing said derivatives, and to their use as medicamentous forms. 7 claims

公开(公告)号：BG104151A

公开(公告)日：2000-10-31

申请号：BG10415100

申请日：2000-02-10

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO X ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14

Abstract: The invention relates to new 3-substituted 3,4,5,7-tetrahydropyrolo[3',4':4,5] thieno] pyrimidine derivatives with the formula where the substituents have the meanings listed in the description, to their preparation and application as medicamentous forms. 6 claims

公开(公告)号：SK1052000A3

公开(公告)日：2000-08-14

申请号：SK1052000

申请日：1998-07-23

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO JAVIER ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14 ,  A61K31/4353

Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.

公开(公告)号：PL337454A1

公开(公告)日：2000-08-14

申请号：PL33745498

申请日：1998-05-29

Applicant: BASF AG

Inventor： STEINER GERD ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO JAVIER ,  EMLING FRANZ

IPC: A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

Abstract: PCT No. PCT/EP98/03231 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56793 PCT Pub. Date Dec. 17, 19983-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I where R1 is a hydrogen atom, a C1-C4-alkyl group, an acetyl group, a phenylalkyl C1-C4 radical, the aromatic system being unsubstituted or substituted by halogen, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it also being possible for the linkage between Y and Z to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.