公开(公告)号：CA2060606A1

公开(公告)日：1992-08-06

申请号：CA2060606

申请日：1992-02-04

Applicant: NUEBLING CHRISOTOPH ,  THEOBALD HANS ,  KARDORFF UWE ,  KRIEG WOLFGANG ,  KUENAST CHRISTOPH ,  BASF AG

Inventor： NUEBLING CHRISTOPH ,  THEOBALD HANS ,  KARDORFF UWE ,  KRIEG WOLFGANG ,  KUENAST CHRISTOPH

IPC: C07D231/10 ,  A01N53/00 ,  A01N53/12 ,  C07C233/60 ,  C07D231/12 ,  C07D233/64 ,  C07D233/70 ,  C07D249/08 ,  C07D261/08 ,  C07D261/12 ,  C07D263/32 ,  C07D263/34 ,  C07D263/38 ,  C07D263/40 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D277/22 ,  C07D285/08 ,  C07D285/12 ,  C07D285/13 ,  C07D307/42 ,  C07D333/16 ,  C07D333/24 ,  C07D277/30 ,  C07D233/54

Abstract: O.Z. 0050/42196 Cyclopropane(thio)carboxamides of the general formula I I where the index and the substituents have the following meanings: n is 0, 1 or 2, it being possible for the R2 radicals to be different when n is 2; A1 and A2 are substituted or unsubstituted alkylene; R1 is hydrogen, halogen or alkyl; R2 is halogen or alkyl; X is substituted or unsubstituted 5-membered heteroaryl, substituted or unsubstituted pyrazolyl-1-oxy or triazolyl-1-oxy; and Y is oxygen or sulfur, processes for their manufacture, intermediates therefor, and the use of compounds 1.

公开(公告)号：DK1119634T3

公开(公告)日：2004-06-28

申请号：DK99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：DK0801683T3

公开(公告)日：2002-06-17

申请号：DK96900601

申请日：1996-01-20

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00

Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

公开(公告)号：TR200102337T2

公开(公告)日：2001-12-21

申请号：TR200102337

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOENN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C9/68

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：NO20013912D0

公开(公告)日：2001-08-10

申请号：NO20013912

申请日：2001-08-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：NO20013912A

公开(公告)日：2001-08-10

申请号：NO20013912

申请日：2001-08-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08 ,  C07C209/88

CPC classification number: C07C213/08 ,  C07C209/68 ,  C07C211/03 ,  C07C217/08

公开(公告)号：DE59606235D1

公开(公告)日：2001-01-25

申请号：DE59606235

申请日：1996-05-07

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  LADNER WOLFGANG

IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56

Abstract: PCT No. PCT/EP96/01884 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/35660 PCT Pub. Date Nov. 14, 1996A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A A b) adding seed crystals of one enantiomer to a super-saturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure trans amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindane.

公开(公告)号：DE19837745A1

公开(公告)日：2000-02-24

申请号：DE19837745

申请日：1998-08-20

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00 ,  C07C209/88 ,  C07B57/00

Abstract: Process for preparing optically active primary amines comprises: (a) reacting a primary amine with a long-chain alkoxyalkanoate or phenoxyalkanoate ester (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine. Process for preparing optically active primary amines comprises: (a) reacting a primary amine with an ester of formula (I) in the presence of a lipase; and (b) separating the enantioselectively acylated amine from the unreacted amine: m = 0 or 1; R = 6-20C alkyl or 6- to 20-membered heteroalkyl, optionally substituted by 1-5 halogen atoms and/or an oxo group; R = 1-8C alkyl or phenyl; R = H or 1-8C alkyl. An Independent claim is also included for a process for acylating primary amines of formula (II), comprising reacting (II) with (I) in the presence of a lipase: n = 0 or 1; R , R = H, 1-8C alkyl or phenyl; R = 1-6C alkyl or benzyl.

公开(公告)号：DE59409010D1

公开(公告)日：2000-01-20

申请号：DE59409010

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：AT187774T

公开(公告)日：2000-01-15

申请号：AT94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.