中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

71 records (took 0.023 seconds)

    33.
    发明专利
    未知

    公开(公告)号：ES2200449T3

    公开(公告)日：2004-03-01

    申请号：ES99118428

    申请日：1999-09-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KLATT MARTIN JOCHEN ,  BOERMER ARMIN ,  HOLZ JENS ,  VOSS GUDRUN

    IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C67/297 ,  C07C67/31 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732

    Abstract: Enantiomerically pure beta -hydroxyesters (I) are prepared by asymmetric hydrogenation of a beta -hydroxyester (II) over a ruthenium complex catalyst (III) containing an optically active bidentate bis-phospholane ligand. Preparation of enantiomerically pure beta -hydroxyesters (I) involves reacting a beta -hydroxyester (II) with hydrogen in presence of a ruthenium complex catalyst of formula (III): LRuX2 (III) X = halo, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate; L = bidentate bis-phospholane ligand of formula (A) : Y = bridging group providing 1-5C between the two P atoms; R1 = H, 1-6C alkyl, aryl, alkaryl or Si(R2)3; R2 = alkyl or aryl; m = 0 and R3 = OR4; or m = 1 and R3 = H; R4 = as R1.

    37.
    发明专利
    未知

    公开(公告)号：DE502004005491D1

    公开(公告)日：2007-12-27

    申请号：DE502004005491

    申请日：2004-01-15

    Applicant: BASF AG

    Inventor： STUERMER RAINER

    IPC: C07D333/22 ,  C07D333/16

    Abstract: 3-methylamino-1-(2-thienyl)-1-propanone (I) and its acid addition salts are new. An Independent claim is also included for preparation of (+)-(S)-N- methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate (II; Duloxetin (RTM)), using (I) or its salt as intermediate.

    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating
    38.
    发明专利
    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating 未知

    公开(公告)号：DE102005062662A1

    公开(公告)日：2007-06-28

    申请号：DE102005062662

    申请日：2005-12-23

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KESELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12N9/04 ,  C12P7/02

    Abstract: Preparation of optically active alkanol compound (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound (II) and isolating the product, where (II) is enzymatically reduced to (I). Preparation of optically active alkanol compound of formula (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound of formula Cyc-(C=O)-(CH 2) n-CH 2-R 1>(II) and isolating the product, where (II) is enzymatically reduced to (I). n : 0-5; Cyc : optionally substituted, mono- or polynuclear, (un)saturated, carbocylic or heterocyclic ring; R 1>halo, SH, OH, NO 2, NR 2>R 3> or NR 2>R 3>R 4+>X ->; R 2>-R 4>H, lower alkyl or lower alkoxy; and X ->counter ion. An independent claim is also included for the enzyme with dehydrogenase activity. [Image] ACTIVITY : Antidepressant; Uropathic. No biological data given. MECHANISM OF ACTION : None given.

    40.
    发明专利
    未知

    公开(公告)号：DE102004055508A1

    公开(公告)日：2006-06-01

    申请号：DE102004055508

    申请日：2004-11-17

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  HAUER BERNHARD ,  DREW DEJANA ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12P7/16

    Abstract: The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.

Patent Agency Ranking