公开(公告)号：WO2006094945A3

公开(公告)日：2007-03-15

申请号：PCT/EP2006060452

申请日：2006-03-03

Applicant: BASF AG ,  STUERMER RAINER ,  DAEUWEL JUERGEN ,  KESSELER MARIA ,  ACHATZ BRIGITTE ,  BREUER MICHAEL

Inventor： STUERMER RAINER ,  DAEUWEL JUERGEN ,  KESSELER MARIA ,  ACHATZ BRIGITTE ,  BREUER MICHAEL

IPC: C12P17/00 ,  C07C27/00 ,  C07D333/16 ,  C12P7/02 ,  C12P7/04

CPC classification number: C12P7/02 ,  C07D333/16 ,  C12P17/00 ,  C12P41/002

Abstract: The invention concerns a method for producing optically active alcohols of formula (I) by means of enzymatic reduction of the corresponding ketones, in particular, the production of (1S)-3-methylamino-1-(2-thienyl)-propane-1-ol and (1S)-3-chlorine-1-(2-thienyl)-propane-1-ol.

Abstract translation: 一种用于制备式（I）通过酶促还原相应的酮的旋光活性的链烷醇，特别是（1S）的制备-3-甲基氨基-1-（2-噻吩基）丙-1-醇和过程（1S） -3-氯-1-（2-噻吩基）丙-1-醇。

公开(公告)号：DE19903459A1

公开(公告)日：2000-08-03

申请号：DE19903459

申请日：1999-01-28

Applicant: BASF AG

Inventor： STREICHER HARALD ,  BURST WOLFRAM ,  DAEUWEL JUERGEN ,  KOPPENHOEFER JUERGEN

IPC: C07C29/80 ,  C07C31/22 ,  B01D3/14

Abstract: Production of highly pure phytantriol (I) comprises rectification of (I) in a fine vacuum in columns with ordered metal fabric packing and duct distributors with ≥ 500 dripping points/m at an angle of 90 degrees to the layer of fabric just below them. There are 2 or more, 20-100 mm high packing elements with layers of fabric at 90 degrees to one another. Strictly adiabatic rectification with absolute exclusion of air is used. Production of highly pure phytantriol (I) comprises rectification of (I) contaminated with lower and/or higher boiling by-products in a fine vacuum in columns containing metal fabric packing with ordered structure. The liquid is distributed with duct distributors with ≥ 500 dripping points/m . The ducts are at an angle of 90 degrees to the layer of fabric directly below them in the packing. There are 2 or more packing elements with a height of 20-100 mm and layers of fabric at 90 degrees to one another, below the distributor. The process is operated with absolute exclusion of air. Strictly adiabatic rectification is used.

公开(公告)号：DE102005010804A1

公开(公告)日：2006-09-14

申请号：DE102005010804

申请日：2005-03-07

Applicant: BASF AG

Inventor： STUERMER RAINER ,  DAEUWEL JUERGEN ,  KESELER MARIA ,  ACHATZ BRIGITTE ,  BREUER MICHAEL

IPC: C12P7/02 ,  C12N9/02 ,  C12P7/22 ,  C12P41/00

公开(公告)号：DE102005000867A1

公开(公告)日：2006-07-13

申请号：DE102005000867

申请日：2005-01-05

Applicant: BASF AG

Inventor： STUERMER RAINER ,  DAEUWEL JUERGEN ,  KESELER MARIA ,  ACHATZ BRIGITTE ,  BREUER MICHAEL

IPC: C07D333/20

Abstract: The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.

公开(公告)号：CA2590660A1

公开(公告)日：2006-07-13

申请号：CA2590660

申请日：2005-12-31

Applicant: BASF AG

Inventor： STUERMER RAINER ,  BREUER MICHAEL ,  DAEUWEL JUERGEN ,  KESSELER MARIA ,  ACHATZ BRIGITTE

IPC: C07D333/20 ,  B01D3/12

Abstract: The present invention relates to a method for purifying (1S)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL by distilling a reaction mixture which comprises between 25 and 99% by weight of (IS)-3-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL.

公开(公告)号：DE10223970A1

公开(公告)日：2003-12-24

申请号：DE10223970

申请日：2002-05-29

Applicant: BASF AG

Inventor： KOENIG JOSEF ,  DAEUWEL JUERGEN ,  GOEBBEL HANS-GEORG ,  BLUEMMEL RUDI

IPC: C07C45/73 ,  C07C45/82 ,  C07C47/228

Abstract: A method for the continuous isolation of dihydrocinnamaldehydes (I) from a crude product mixture involves distillation in an integrated system comprising a feed column (A) and a take-off column (D) with combination columns (B, C) at the upper and lower ends, a lateral feed point in (A) and a lateral take-off point in (D) for pure (I). A method for the continuous isolation of dihydrocinnamaldehydes (I) from a crude product mixture involves (i) feeding the mixture into the side of a column (A) with a booster section above and a stripper section below the feed point, the top of (A) being connected (ii) to an upper combination column (B) with a condenser at the top and the bottom of (A) being connected to a lower combination column (C) with a sump heater, while (iii) a take-off column (D) is connected to (B) and (C), and (iv) taking off (I) as a side stream from (D) while lower-boiling and higher-boiling compounds are taken from the top of column (B) and the bottom of column (C) respectively.

公开(公告)号：DE50000369D1

公开(公告)日：2002-09-19

申请号：DE50000369

申请日：2000-01-05

Applicant: BASF AG

Inventor： STREICHER DR ,  BURST WOLFRAM ,  DAEUWEL JUERGEN ,  KOPPENHOEFER JUERGEN

IPC: C07C29/80 ,  C07C31/22

Abstract: Production of highly pure phytantriol (I) comprises rectification of (I) in a fine vacuum in columns with ordered metal fabric packing and duct distributors with ≥ 500 dripping points/m at an angle of 90 degrees to the layer of fabric just below them. There are 2 or more, 20-100 mm high packing elements with layers of fabric at 90 degrees to one another. Strictly adiabatic rectification with absolute exclusion of air is used. Production of highly pure phytantriol (I) comprises rectification of (I) contaminated with lower and/or higher boiling by-products in a fine vacuum in columns containing metal fabric packing with ordered structure. The liquid is distributed with duct distributors with ≥ 500 dripping points/m . The ducts are at an angle of 90 degrees to the layer of fabric directly below them in the packing. There are 2 or more packing elements with a height of 20-100 mm and layers of fabric at 90 degrees to one another, below the distributor. The process is operated with absolute exclusion of air. Strictly adiabatic rectification is used.