公开(公告)号：WO1984005000A1

公开(公告)日：1984-12-20

申请号：PCT/US1984000856

申请日：1984-05-30

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  EHRET, Robert, James ,  WRIGHT, Herschel, Eugene

IPC: H02P05/40

CPC classification number: H02P23/08

Abstract: A variable slip drive system for driving a variable speed induction motor. The system includes a tachometer for providing a signal proportional to the speed of the motor and a slip oscillator. The output of the tachometer and slip oscillator are combined by a motor drive oscillator to provide a motor drive signal. The frequency of the motor drive signal equals the tachometer signal, less the frequency of the slip signal. The motor drive signal is converted into a proportional, three-phase, high power signal for powering the motor. The frequency of the slip signal is controlled so as to be proportional to the motor speed as a means of optimizing the motor's performance.

公开(公告)号：WO1984004749A1

公开(公告)日：1984-12-06

申请号：PCT/US1984000743

申请日：1984-05-14

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BEAUCAGE, Serge, Laurent

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C07F9/572 ,  Y02P20/55

Abstract: Nucleoside phosphoramidite intermediates are prepared by a chemical reaction represented by a formula: In addition, nucleoside phosphoramidite intermediates are prepared by a chemical reaction represented by the following formula: In both of the above chemical reaction formulas, X is a phosphate protecting group; each Y is a secondary amino group; Z is a hydroxy protecting group; the weak acid is capable of selectively protonating only one amine of the secondary amino groups; each A is selected from a group consisting of -H, -OH, and -OZ; B is selected from a group consisting of natural and unnatural purine and pyrimidine bases; G is a heterocyclic base protecting group; each D is selected from a group consisting of -H and -OZ; E is selected from a group consisting of -OH and -OZ, provided that (a) when both As are the same and are -H or -OZ, then E is -OH and (b) both As and E cannot all simultaneously be equal; n is a number from 0-2; r, s, and t are each 0 or 1, provided that r + s + t = 2; the solvent is capable of (a) solubilizing I, II, and III and (b) allowing the reaction to proceed; and III is present in a molar concentration at least equal to the molar concentration of reactable I. Also, a novel compound having a formula wherein X is methyl.

Abstract translation: 核苷亚磷酰胺中间体通过下式表示的化学反应制备：另外，通过下述化学反应制备核苷亚磷酰胺中间体：在上述两种化学反应式中，X是 磷酸酯保护基; 每个Y是仲氨基; Z是羟基保护基; 弱酸能够仅选择性地仅质子化仲胺基的一个胺; 每个A选自-H，-OH和-OZ; B选自天然和非天然嘌呤和嘧啶碱基组成的组; G为杂环基保护基; 每个D选自-H和-OZ; E选自-OH和-OZ，条件是（a）当两个As相同并且是-H或-OZ时，E是-OH和（b）As和E都不能同时被 等于; n是0-2的数字; r，s和t分别为0或1，条件是r + s + t = 2; 溶剂能够（a）溶解I，II和III和（b）使反应进行; 和III的摩尔浓度至少等于可反应的I的摩尔浓度。另外，具有式“IMAGE”的新化合物，其中X是甲基。

公开(公告)号：WO1983003009A1

公开(公告)日：1983-09-01

申请号：PCT/US1982001749

申请日：1982-12-13

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  JACKSON, Delbert, Durwood

IPC: G01N35/08

CPC classification number: G01N35/08

Abstract: In clinical analyzers in which fluid to be analyzed is aspirated into the analyzer by a probe immersed in a sample cup, withdrawal of insufficient sample quantity can cause inaccuracy in the analysis. The invention includes an electromagnetic sensing device (22) in a conduit (17) into which the sample liquid is mixed. The electromagnetic sensing device detects the presence of air (18) in the conduit (17) which indicates that an insufficient liquid volume has been aspirated.

Abstract translation: 在临床分析仪中，要分析的液体通过浸在样品杯中的探针吸入分析仪，取样量不足可能导致分析不准确。 本发明包括在导管（17）中的电磁感测装置（22），混合有样品液体。 电磁感测装置检测导管（17）中存在空气（18），这表明已经吸出不足的液体体积。

公开(公告)号：WO1983002370A1

公开(公告)日：1983-07-07

申请号：PCT/US1982001809

申请日：1982-12-21

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  FRANKLIN, Robert, C.

IPC: H02M01/12

CPC classification number: H02M1/44 ,  H02M1/12 ,  H02M7/062 ,  H02M7/1552

Abstract: Un régulateur de tension de commutation est destiné au couplage d'une source de potentiel de courant alternatif à une charge de courant continu. Des moyens à thyristors redresseurs d'ondes pleines fournissent une source de potentiel à courant continu qui est connectée à la charge par l'intermédiaire d'une inductance en série avec sa charge. L'entrée de l'inductance est shuntée par une diode de commutation qui forme un circuit pour le courant inductif lorsque les moyens à thyristors se trouvent dans une phase de non-conduction de leurs cycles de fonctionnement. Des moyens de circuit sont prévus pour inverser la polarisation de la diode de commutation à l'avance de chaque cycle de conduction des moyens à thyristors. En conséquence, le niveau d'interférences de hautes fréquences (RFI) conduites vers la ligne de puissance à courant alternatif est considérablement réduit.

公开(公告)号：WO1998022509A1

公开(公告)日：1998-05-28

申请号：PCT/US1997020935

申请日：1997-11-17

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  KUUS-REICHEL, Kristine ,  LINTON, Harry, Jay ,  PAYNE, Janice, K. ,  WANG, Tang, Jang

IPC: C07K16/40

CPC classification number: C12N9/6445 ,  C07K14/8121 ,  C07K16/38 ,  C07K16/40

Abstract: Monoclonal antibodies have been developed which specifically bind the PSA-ACT complex without significant cross-reactivity with PSA, ACT or CG-ACT. The antibodies were generated using a unique immunogen comprising a PSA-ACT complex having bound to monoclonal antibodies against PSA and monoclonal antibodies against ACT. It is theorized that the antibodies against PSA and ACT block immunodominant sites on the PSA-ACT complex. The antibodies generated against the unique immunogen specifically bind the PSA-ACT complex, but have no significant cross-reactivity with either PSA or ACT. The monoclonal antibodies of the present invention can be used in immunoassays to specifically detect PSA-ACT in a sample.

Abstract translation: 已经开发了单克隆抗体，其特异性结合PSA-ACT复合物，而与PSA，ACT或CG-ACT没有显着的交叉反应性。 使用独特的免疫原产生抗体，所述免疫原包含结合针对PSA的单克隆抗体和针对ACT的单克隆抗体的PSA-ACT复合物。 理论上，PSA和ACT抗体在PSA-ACT复合物上阻断免疫显性位点。 针对独特免疫原产生的抗体特异性结合PSA-ACT复合物，但与PSA或ACT无明显交叉反应。 本发明的单克隆抗体可用于免疫测定以特异性检测样品中的PSA-ACT。

公开(公告)号：WO1998000701A1

公开(公告)日：1998-01-08

申请号：PCT/US1997006994

申请日：1997-04-28

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BARBER, Duane, G. ,  TU, Songtai ,  WATTS, Richard, P.

IPC: G01N21/51

CPC classification number: G01N21/532 ,  G01N21/253 ,  G01N35/025 ,  G01N35/1004 ,  G01N2035/00435 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0451 ,  G01N2035/1086 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831

Abstract: A nephelometer and nephelometer/turbidimeter combination of the type useful in automated chemical analyzers is provided. The combination includes a laser for generating a polarized laser beam having an S-wave component and a P-wave component. The beam is split by a beam splitter specially constructed so that a known proportion of one of the two polarized portions of the beam is directed to a reaction container. In the reaction container, a first polarized component of the laser beam is used in a nephelometric chemical analysis. The remainder of the laser beam passes through the beam splitter to a laser control light detector. Before the remainder of the laser beam reaches the laser control light detector, however, the polarized component which is not used in nephelometric chemical analysis is filtered out. The laser control detector uses the non-filtered portion of the laser beam to control the output of the laser. The combination also includes an LED which emits a beam of light at a longer wavelength than that of the laser. Such beam of light is projected through the reaction container to a turbidimeter light detector. A second beam splitter is provided between the reaction container and the turbidimeter light detector to deflect the residual portion of the laser beam away from the laser. This prevents the residual portion of the laser beam from being reflected back into the reaction container.

Abstract translation: 提供了一种可用于自动化学分析仪的浊度计和浊度计/浊度计组合。 该组合包括用于产生具有S波分量和P波分量的偏振激光束的激光器。 光束被特别构造的分束器分裂，使得梁的两个偏振部分中的一个的已知比例被引导到反应容器。 在反应容器中，激光束的第一偏振分量用于比浊法化学分析。 激光束的其余部分通过分束器通过激光控制光检测器。 然而，在激光束的其余部分到达激光控制光检测器之前，滤除在比浊法化学分析中未使用的偏振分量。 激光控制检测器使用激光束的未滤波部分来控制激光器的输出。 该组合还包括发射比激光器更长波长的光束的LED。 这样的光束通过反应容器投射到浊度计光检测器。 第二分束器设置在反应容器和浊度计光检测器之间，以将激光束的剩余部分偏离激光。 这防止激光束的剩余部分反射回到反应容器中。

公开(公告)号：WO1998000700A1

公开(公告)日：1998-01-08

申请号：PCT/US1997009152

申请日：1997-05-30

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WATTS, Richard, P. ,  MC NEAL, Jack, D.

IPC: G01N21/47

CPC classification number: G01N21/4785 ,  G01N21/278

Abstract: A non-liquid scatter standard for use in nephelometry and turbidimetry systems which comprises a clear silicon rubber gel in which an effective light scattering amount of inorganic particles are suspended. The particles have an index of refraction greater than that of the silicon rubber gel.

Abstract translation: 一种用于比浊法和比浊法系统的非液体散射标准，其包括悬浮有效光散射量的无机颗粒的透明硅橡胶凝胶。 颗粒的折射率大于硅橡胶胶的折射率。

公开(公告)号：WO1997040458A2

公开(公告)日：1997-10-30

申请号：PCT/US1997006648

申请日：1997-04-21

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  REDDY, M., Parameswara ,  MICHAEL, Maged, A. ,  FAROOQUI, Firdous

IPC: G06F17/30

CPC classification number: C07H21/00 ,  Y02P20/55

Abstract: Universal solid support oligonucleotide synthesis reagents, oligonucleotide synthesis processes, and reagents for cleaving oligonucleotides from solid supports are disclosed. Oligonucleotide synthesis reagents have the following general formula: SS - R - O - R wherein SS is a solid support; R is (a), (b) or (c), where R is hydrogen or alkyl and R is a phosphate protecting group; and R is a ring moiety having vicinal groups -XR and -YR wherein each of X and Y is independently selected from the group consisting of O, S and NH and one of R and R is a blocking moiety and the other is hydrogen or a hydroxy protecting group. Oligonucleotide cleaving reagents include methylamine and/or ammonium hydroxide and trimethylamine.

Abstract translation: 公开了通用固体支持寡核苷酸合成试剂，寡核苷酸合成方法和用于从固体支持物切割寡核苷酸的试剂。 寡核苷酸合成试剂具有以下通式：SS-R 6 -O-R 3其中SS是固体支持物; R 6是（a），（b）或（c），其中R 5是氢或烷基，R 4是磷酸酯保护基; 并且R 3是具有连位-XR 1和-YR 2的环部分，其中X和Y各自独立地选自O，S和NH以及R 1和 R 2是封端部分，另一个是氢或羟基保护基团。 寡核苷酸切割试剂包括甲胺和/或氢氧化铵和三甲胺。

公开(公告)号：WO1997032212A1

公开(公告)日：1997-09-04

申请号：PCT/US1997002748

申请日：1997-02-24

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  OBREMSKI, Robert ,  SILZEL, John, W.

IPC: G01N33/543

CPC classification number: G01N21/648 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/54373

Abstract: A system for simultaneously conducting multiple ligand assays on a sample potentially containing target analytes uses as a detector a waveguide having thereon a plurality of probes of known recognition to the target analytes. The probes are in discrete areas on the waveguide. A sample containing target analyte is treated with a light-responsive compound such that it binds to the target analyte to form a conjugate and the conjugate is applied to the probes on the waveguide. A laser light is passed into the waveguide so that evanescent waves radiate from the waveguide. Where conjugate has attached to probe there is emission of light different from that emitted by a probe without conjugate attached thereto.

Abstract translation: 用于在潜在地含有目标分析物的样品上同时进行多个配体测定的系统用作其上具有已知识别到目标分析物的多个探针的检测器。 探针位于波导上的离散区域中。 用光响应化合物处理含有目标分析物的样品，使其与目标分析物结合形成共轭物，并将缀合物施加到波导上的探针上。 将激光传送到波导中，使得ev逝波从波导辐射。 当缀合物连接到探针上时，发射不同于由其连接的缀合物的探针发射的光。

公开(公告)号：WO1997008545A1

公开(公告)日：1997-03-06

申请号：PCT/US1996013165

申请日：1996-08-12

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  PENTONEY, Stephen, L., Jr. ,  PETERSON, Brian, D. ,  OSBORNE, James, C. ,  KEENAN, Charles, A.

IPC: G01N27/447

CPC classification number: G01N27/44704 ,  G01N27/44782

Abstract: A gel pump operated by a stepper motor may be used to deliver fresh gel to one or more capillaries through one or more manifolds and valves. By controlling the valves, fresh gel delivered by the pump will replace the old gel in the capillaries for an automated gel replacement system. In a different setting of the valves, the manifolds may be purged of the old gel prior to delivery of fresh gel to the capillaries. The gel delivery system may also be combined with an electrophoresis system so that sealing connection capable of withstanding high pressure adequate for gel injection need not be frequently broken when the gel is to be replaced. Manifold/reflector assembly is advantageously used in the system that facilitates electrical circuit for electrophoresis and for gel replacement.

Abstract translation: 由步进电动机操作的凝胶泵可以用于通过一个或多个歧管和阀将新鲜的凝胶递送到一个或多个毛细管。 通过控制阀门，由泵输送的新鲜凝胶将替代毛细管中的旧凝胶，用于自动凝胶置换系统。 在阀的不同设置中，在将新鲜凝胶递送至毛细管之前，歧管可以被清除旧凝胶。 凝胶递送系统还可以与电泳系统组合，使得当要更换凝胶时，不需要频繁地破坏能够耐受用于凝胶注射的高压的密封连接。 歧管/反射器组件有利地用于便于用于电泳和凝胶置换的电路的系统中。