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    Titration method and apparatus
    32.
    发明授权
    Titration method and apparatus 失效
    调查方法和装置

    公开(公告)号：US3692483A

    公开(公告)日：1972-09-19

    申请号：US3692483D

    申请日：1971-02-22

    Applicant: BECKMAN INSTRUMENTS INC

    Inventor： STERNBERG JAMES C

    IPC: G01N31/16

    CPC classification number: G01N31/162 ,  Y10T436/116664

    Abstract: A METHOD AND APPARATUS FOR PERFORMING TITRATIONS IN WHICH A SUBSTANTIALLY CONSTANT HYDROSTATIC HEAD OF TITRANT IS MAINTAINED IN A TITRANT RESERVOIR. AN ELONGATED CAPILLARY TUBE IS CONNECTED AT ONE END TO THE RESEVOIR AND THE OTHER END OF THE TUBE, CONSTITUTING THE TITRANT DELIVERY TIP, IS NORMALLY POSITIONED AT LEAST AS HIGH AS THE LEVEL OF TITRANT IN THE RESEVOIR SO THAT NO TIRANT FLOWS THROUGH THE TUBE. A SAMPLE IS DELIVERED TO A CELL BELOW THE TITRANT DELIVERY TIP. THE TITRANT DELIVERY TIP IS LOWERED TO ADJACENT THE CELL WHEREBY TITRANT WILL FLOW BY GRAVITY INTO THE CELL THE COMMENCE A TITRATION REACTION. MEANS ARE PROVIDED FOR DETECTING THE END POINT OF THE TITRATION REACTION IN THE CELL. THE TIME ELAPSED BETWEEN THE INTRODUCITON OF TITRANT INTO THE CELL AND THE TIME SUCH END POINT IS REACHED IS MEASURED. AFTER THE END POINT HAS BEEN DETECTED, THE TITRANT DELIVERY TIP IS RAISED TO THE LEVEL OF TITRANT IN THE TITRANT RESERVOIR TO CEASE FURTHER FLOW OF TITRANT INTO THE SAMPLE CELL. SINCE A CONSTANT HYDROSTATIC HEAD OF TITRANT IS PROVIDED, THE TITRANT WILL FLOW AT A CONTANT KNOWN RATE INTO THE CELL. BY KNOWING THE RATE OF FLOW OF TITRANT AND THE TIME THAT TITRANT FLOWS INTO THE SAMPLE CELL, THE TITER OF THE SAMPLE MAY BE DETERMINED.

    Temperature-controlled discrete sample analyzer
    33.
    发明授权
    Temperature-controlled discrete sample analyzer 失效
    温度控制分离样品分析仪

    公开(公告)号：US3616264A

    公开(公告)日：1971-10-26

    申请号：US3616264D

    申请日：1969-06-30

    Applicant: BECKMAN INSTRUMENTS INC

    Inventor： RAY ROBERT A ,  STERNBERG JAMES C

    IPC: B01L7/00 ,  G01N21/25 ,  C12K1/10

    CPC classification number: G01N21/251 ,  B01L7/00 ,  Y10S435/808

    Abstract: There is disclosed an apparatus for controlling the temperature of discrete sample containers in analytical instrumentation. A conveyor containing discrete samples to be analyzed is located in a subcompartment within a larger enclosure. A fan is mounted in a first opening in the subcompartment to move air from the large enclosure into the subcompartment. A second opening in which a thermal energy transfer element is mounted allows the passage of the air over the thermal energy transfer element back into the larger enclosure. A temperature sensor contacts a sample container being measured to provide a control signal which is applied to a proportionally controlled power supply connected to the thermal energy transfer element.

    38.
    发明专利
    未知

    公开(公告)号：ES2102533T3

    公开(公告)日：1997-08-01

    申请号：ES92925261

    申请日：1992-11-16

    Applicant: BECKMAN INSTRUMENTS INC

    Inventor： HSIEH YOU-ZUNG ,  CHEN FU-TAI A ,  STERNBERG JAMES C ,  KLIEN GERALD ,  LIU CHENG-MING

    IPC: C12Q1/04 ,  C12Q1/00 ,  G01N27/447

    Abstract: Disclosed herein is a methodology for analyzing isoenzymes using capillary zone electrophoresis ("CZE") techniques. Briefly, an isoenzyme-containing sample and a substrate capable of being catalyzed by said isoenzyme into a reaction product are introduced into a capillary column comprising a buffer. Most preferably, the buffer contains the substrate prior to introduction of the sample into such substrate-buffer. CZE separation techniques are applied to the column such that the isoenzymes are separated from each other into discrete zones. The separation techniques are terminated such that product is rapidly generated by the catalytic conversion of substrate by the isoenzymes, and accumulated, within each discrete zone, followed by detection of product. Information regarding the relative distribution of the isoenzymes can be derived from the relative distribution of the product.

    Methods and apparatus for separating and mobilizing solutes in a solute mixture
    40.
    发明专利
    Methods and apparatus for separating and mobilizing solutes in a solute mixture 未知

    公开(公告)号：AU664966B2

    公开(公告)日：1995-12-07

    申请号：AU6092694

    申请日：1994-01-19

    Applicant: BECKMAN INSTRUMENTS INC

    Inventor： HERRICK STEVEN S ,  STERNBERG JAMES C

    IPC: B01D57/02 ,  G01N27/447

    Abstract: The present invention provides processes for isoelectric focusing ("IEF") and associated detection, which incorporates a dynamic means of electroosmotic flow ("EOF") control during IEF and/or after IEF to effect solute mobilization. In accordance with the present invention, the EOF control during IEF and/or solute mobilization after IEF are accomplished by applying an external electric field, relative to an internal electric field, to modify the electroosmotic flow in the capillary. This can be done by disposing a conductive member at one or more locations outside and along the buffer column in the capillary. The conductive member may be statically charged or caused to conduct a current to create the external required electric field. The applied external electric field may be adjusted, relative to the internal electric field, during IEF as necessary to reduce or completely suppress EOF to prevent flow of the buffer. Upon the completion of IEF (irrespective of the method of reducing or removing EOF during IEF), the external electric field is adjusted, relative to the internal electric field, such that the buffer carrying the focused solutes is moved electroosmotically through the capillary past a detection point. The present invention is applicable to internally coated capillary which suppresses EOF even in the absence of the external electric field.

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