公开(公告)号：DE68912226T2

公开(公告)日：1994-06-01

申请号：DE68912226

申请日：1989-07-25

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R

IPC: G01N30/14 ,  G01N30/46 ,  G01N30/88 ,  G01N33/94 ,  G01N33/48 ,  G01N30/02

公开(公告)号：DE68912226D1

公开(公告)日：1994-02-24

申请号：DE68912226

申请日：1989-07-25

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R

IPC: G01N30/14 ,  G01N30/46 ,  G01N30/88 ,  G01N33/94 ,  G01N33/48 ,  G01N30/02

公开(公告)号：CA1317481C

公开(公告)日：1993-05-11

申请号：CA604487

申请日：1989-06-30

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R

IPC: G01N30/14 ,  G01N30/46 ,  G01N30/88 ,  G01N33/94 ,  G01N33/48 ,  G01N30/02

Abstract: SYSTEM AND METHOD FOR BROAD SPECTRUM DRUG DETECTION Biological fluid test samples are analyzed for a broad spectrum of drugs, including benzodiazepines, amphetamines, tricyclic antidepressants and opiates, in a single isocratic analysis using a chromatographic column system containing three analytical columns -- an anion exchange column, a reversed phase column and a cation exchange column. A pre-column is also included to purge the sample of salts, proteins, peptides and hydrophilic anions. Carrier liquids containing acetonitrile at various strengths are used for distribution of the various drugs among the columns, elution of the drugs from the columns, and column purging and conditioning. The system readily lends itself to automation, automatic periodic sampling, and component identification and quantification. B16/2558B-292F

公开(公告)号：CA2480521C

公开(公告)日：2010-09-14

申请号：CA2480521

申请日：2003-03-28

Applicant: BIO RAD LABORATORIES

Inventor： WATKINS MICHAEL I ,  BINDER STEVEN R ,  RASKIN ALEKSANDER

IPC: G01N33/545 ,  G01N33/53 ,  G01N33/543

Abstract: Water-soluble polymer is added to the liquid phase in a heterogeneous immunoassay of serum, the polymer having monomers in common with monomers of the solid phase surface. This reduces non-specific binding of IgG's from the serum to the solid phase surface and thereby reduces the occurrence of false positive readings in the immunoassay.

公开(公告)号：DE60327849D1

公开(公告)日：2009-07-16

申请号：DE60327849

申请日：2003-03-28

Applicant: BIO RAD LABORATORIES

Inventor： WATKINS MICHAEL I ,  BINDER STEVEN R ,  RASKIN ALEKSANDER

IPC: G01N33/53 ,  G01N33/543

Abstract: Water-soluble polymer is added to the liquid phase in a heterogeneous a immunoassay of serum, the polymer having monomers in common with monomers of the solid phase surface. This reduces non-specific binding of IgG's from the serum to the solid phase surface and thereby reduces the occurrence of false positive readings in the immunoassay.

公开(公告)号：AU2002257350B2

公开(公告)日：2005-09-29

申请号：AU2002257350

申请日：2002-05-28

Applicant: BIO RAD LABORATORIES

Inventor： GOODRICH JODI L ,  BINDER STEVEN R ,  SAFARIAN ZARA

IPC: G01N33/53 ,  G01N33/96 ,  C07K016/36 ,  C07K016/00

Abstract: Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.

公开(公告)号：AU2003226177A1

公开(公告)日：2003-10-27

申请号：AU2003226177

申请日：2003-03-28

Applicant: BIO RAD LABORATORIES

Inventor： WATKINS MICHAEL I ,  BINDER STEVEN R ,  RASKIN ALEKSANDER

IPC: G01N33/543

Abstract: Water-soluble polymer is added to the liquid phase in a heterogeneous a immunoassay of serum, the polymer having monomers in common with monomers of the solid phase surface. This reduces non-specific binding of IgG's from the serum to the solid phase surface and thereby reduces the occurrence of false positive readings in the immunoassay.

公开(公告)号：CA2480521A1

公开(公告)日：2003-10-23

申请号：CA2480521

申请日：2003-03-28

Applicant: BIO RAD LABORATORIES

Inventor： RASKIN ALEKSANDER ,  BINDER STEVEN R ,  WATKINS MICHAEL I

IPC: G01N33/543 ,  G01N33/545 ,  G01N33/53

Abstract: Water-soluble polymer is added to the liquid phase in a heterogeneous immunoassay of serum, the polymer having monomers in common with monomers of the solid phase surface. This reduces non-specific binding of IgG's from the serum to the solid phase surface and thereby reduces the occurrence of false positive readings in the immunoassay.

公开(公告)号：CA2275853C

公开(公告)日：2002-06-11

申请号：CA2275853

申请日：1999-06-21

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R ,  IKEDA BRYAN H ,  SCOLARI CAROLINE

IPC: G01N33/53 ,  G01N33/68 ,  G01N1/28 ,  G01N1/36 ,  G01N1/40

Abstract: The present invention is generally directed to the analysis of biologic al samples. More particularly, the present invention is directed to automated sample analysis for paraproteins using immunosubtraction, capillary electrophoresis and Fourier transformation analysis.

公开(公告)号：CA2297092A1

公开(公告)日：1999-01-28

申请号：CA2297092

申请日：1998-07-21

Applicant: BIO RAD LABORATORIES

Inventor： SCOLARI CAROLINE ,  BINDER STEVEN R ,  LIKUSKI ROBERT K

IPC: G01N27/447

Abstract: Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting levels of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.