公开(公告)号：AU2011207649B2

公开(公告)日：2014-02-20

申请号：AU2011207649

申请日：2011-01-19

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  BARTLING DONALD J ,  YAO KUNQUAN ,  LE TONG ,  MATSUMOTO KENT

IPC: G01N1/00

Abstract: An automated analyzer for biological samples that contain particulate matter is adapted to be able to process a large number of samples without changing the analytical cartridge, and in many cases without changing the internal switching valves, by including a filter in the low-pressure section of the analyzer, and preferably configuring the analyzer to be able to perform backflushing on the filter between sample injections.

公开(公告)号：AU2011212806A1

公开(公告)日：2012-08-16

申请号：AU2011212806

申请日：2011-02-04

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  PRESTIGIACOMO ANTHONY F ,  LE TONG ,  KRAMER KURT D ,  BARTLING DON

IPC: G01N35/08

Abstract: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.

公开(公告)号：CA2260779C

公开(公告)日：2007-01-23

申请号：CA2260779

申请日：1998-05-14

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K

IPC: G01N27/447

Abstract: Identification and quantification of constituents of a sample is achieved by mobility-based electropherograms obtained from capillary electrophoresis, the mobilities being normalized by zero correction followed by division by the mobility of a selected marker. Zero correction is achieved either relative to a separate marker or by calculatio n based on the same marker. The resulting electropherograms are more recognizable since they more closely resemble the scanned separation patterns obtained with planar gels, and individual constituents of the sample are more easily and reliably identified since their positions in the electropherogram are substantially constant from one electropherogram to the next and hence reproducible to a high degree of accuracy.

公开(公告)号：AU8571998A

公开(公告)日：1999-02-10

申请号：AU8571998

申请日：1998-07-21

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R ,  SCOLARI CAROLINE ,  LIKUSKI ROBERT K

IPC: G01N27/447 ,  G01N27/26

Abstract: Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting levels of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.

公开(公告)号：AU2011212806B2

公开(公告)日：2014-09-11

申请号：AU2011212806

申请日：2011-02-04

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  PRESTIGIACOMO ANTHONY F ,  LE TONG ,  KRAMER KURT D ,  BARTLING DON

IPC: G01N35/08

Abstract: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.

公开(公告)号：AU2011207649A1

公开(公告)日：2012-07-19

申请号：AU2011207649

申请日：2011-01-19

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  BARTLING DONALD J ,  YAO KUNQUAN ,  LE TONG ,  MATSUMOTO KENT

IPC: G01N1/00

Abstract: An automated analyzer for biological samples that contain particulate matter is adapted to be able to process a large number of samples without changing the analytical cartridge, and in many cases without changing the internal switching valves, by including a filter in the low-pressure section of the analyzer, and preferably configuring the analyzer to be able to perform backflushing on the filter between sample injections.

公开(公告)号：CA2788077A1

公开(公告)日：2011-08-11

申请号：CA2788077

申请日：2011-02-04

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  PRESTIGIACOMO ANTHONY F ,  LE TONG ,  KRAMER KURT D ,  BARTLING DON

IPC: G01N35/08

Abstract: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.

公开(公告)号：CA2297092A1

公开(公告)日：1999-01-28

申请号：CA2297092

申请日：1998-07-21

Applicant: BIO RAD LABORATORIES

Inventor： SCOLARI CAROLINE ,  BINDER STEVEN R ,  LIKUSKI ROBERT K

IPC: G01N27/447

Abstract: Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting levels of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.

公开(公告)号：AU2011207649C1

公开(公告)日：2014-07-17

申请号：AU2011207649

申请日：2011-01-19

Applicant: BIO RAD LABORATORIES

Inventor： LIKUSKI ROBERT K ,  BARTLING DONALD J ,  YAO KUNQUAN ,  LE TONG ,  MATSUMOTO KENT

IPC: G01N1/00

Abstract: An automated analyzer for biological samples that contain particulate matter is adapted to be able to process a large number of samples without changing the analytical cartridge, and in many cases without changing the internal switching valves, by including a filter in the low-pressure section of the analyzer, and preferably configuring the analyzer to be able to perform backflushing on the filter between sample injections.

公开(公告)号：CA2297092C

公开(公告)日：2003-11-25

申请号：CA2297092

申请日：1998-07-21

Applicant: BIO RAD LABORATORIES

Inventor： SCOLARI CAROLINE ,  LIKUSKI ROBERT K ,  BINDER STEVEN R

IPC: G01N27/447

Abstract: Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting level s of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.