公开(公告)号：EP1030912A4

公开(公告)日：2007-01-10

申请号：EP98958589

申请日：1998-11-12

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  LEE SANG-WOOK

IPC: C12M1/33 ,  C12M3/08 ,  C12N1/06 ,  C12N13/00 ,  C12C1/00

CPC classification number: C12M47/06 ,  C12N1/066 ,  C12N13/00

公开(公告)号：EP0878013A4

公开(公告)日：2000-04-12

申请号：EP96920094

申请日：1996-01-19

Applicant: UNIV CALIFORNIA ,  CALIFORNIA INST OF TECHN

Inventor： HO CHIH-MING ,  MIU DENNY K ,  LEU JEREMY TZONG-SHYNG ,  MILLER RAANAN ,  DESAI AMISH ,  LIU CHANG ,  TSAO TOM ,  TAI YU-CHONG

IPC: H01F7/00 ,  H02K57/00

CPC classification number: H02K99/00

Abstract: A surface micromachined micromagnetic actuator is provided with a flap (14) using magnetic force as the actuating force. The flap is coupled by one or more beams (16) to a substrate and is cantilevered over the substrate. A Permalloy layer or a magnetic coil (12) is disposed on the flap such that when the flap is placed in a magnetic field, it can be caused to selectively interact and rotate out of the plane of the magnetic actuator. The cantilevered flap is released from the underlying substrate by etching out an underlying sacrificial layer disposed between the flap and the substrate (22). The etched out and now cantilevered flap is magnetically actuated to maintain it out of contact with the substrate while the just etched device is dried in order to obtain high release yields.

公开(公告)号：EP0954450A4

公开(公告)日：2000-03-22

申请号：EP98904706

申请日：1998-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： TAI YU-CHONG ,  XING YANG ,  GROSJEAN CHARLES

IPC: B81B3/00 ,  F15C5/00 ,  F16K99/00 ,  B44C1/22 ,  F16K31/12

CPC classification number: F16K99/0001 ,  B81B2201/054 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81C1/00158 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/008

公开(公告)号：WO2012129574A3

公开(公告)日：2012-12-27

申请号：PCT/US2012030624

申请日：2012-03-26

Applicant: CALIFORNIA INST OF TECHN ,  UNIV LOUISVILLE RES FOUND ,  BURDICK JOEL W ,  TAI YU-CHONG ,  NABER JOHN F ,  KEYNTON ROBERT S

Inventor： BURDICK JOEL W ,  TAI YU-CHONG ,  NABER JOHN F ,  KEYNTON ROBERT S

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/08

CPC classification number: A61N1/36103 ,  A61B5/0492 ,  A61B5/1106 ,  A61B5/407 ,  A61B5/4076 ,  A61B5/4836 ,  A61B2505/09 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36107 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36139

Abstract: A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.

Abstract translation: 一种用于与组（例如多于四组）电极组合的神经刺激器装置。 神经刺激器可以包括被配置为向每个组递送不同刺激的刺激组件。 神经刺激器还可以包括至少一个处理器，该处理器被配置为引导刺激组件将刺激传递给组。 输送到至少一个组的刺激可以包括除了正方形或矩形波形之外的一个或多个波形。 处理器可以从一个或多个传感器接收数据，并使用该数据来修改递送的刺激。 神经刺激器可以被配置为与外部计算设备进行通信。 神经刺激器可以向计算设备发送数据和/或从计算设备接收数据和/或指令。 计算设备可以使用由一个或多个传感器收集的信息来至少部分地确定刺激参数以与神经刺激器通信。

公开(公告)号：WO2011150357A3

公开(公告)日：2012-04-26

申请号：PCT/US2011038390

申请日：2011-05-27

Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  LU BO

Inventor： TAI YU-CHONG ,  LU BO

IPC: G01N33/48 ,  C12M1/12 ,  C40B30/04 ,  G01N33/15 ,  G01N33/574

CPC classification number: G01N33/5011 ,  B01D65/10

Abstract: The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of "key engineering design parameters" that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.

Abstract translation: 本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。 这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。 这些重要的设计参数包括过滤器几何设计，流体输送方法，输送机压力和总过滤时间。

公开(公告)号：WO2010135603A2

公开(公告)日：2010-11-25

申请号：PCT/US2010035684

申请日：2010-05-20

Applicant: CALIFORNIA INST OF TECHN ,  UNIV SOUTHERN CALIFORNIA ,  GOLDKORN AMIR ,  TAI YU-CHONG ,  XU TONG ,  LU BO

Inventor： GOLDKORN AMIR ,  TAI YU-CHONG ,  XU TONG ,  LU BO

IPC: C12Q1/25 ,  C12N5/09 ,  C12Q1/68 ,  G01N33/50

CPC classification number: G01N33/57496 ,  C12N5/0693 ,  C12N2503/00 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Y207/07049 ,  G01N1/30 ,  G01N1/4077 ,  G01N33/5094 ,  G01N2001/4088 ,  G01N2333/9128 ,  Y10T436/25375

Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.

Abstract translation: 本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器， 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。

公开(公告)号：WO2005048302A3

公开(公告)日：2006-11-09

申请号：PCT/US2004036048

申请日：2004-10-29

Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  RODGER DAMIEN C

Inventor： TAI YU-CHONG ,  RODGER DAMIEN C

IPC: H01L21/48 ,  H01L20060101 ,  H01L21/44 ,  H01L21/60 ,  H01L21/68 ,  H01L23/02 ,  H01L23/538 ,  H01L29/40

CPC classification number: H01L24/19 ,  B81C1/0023 ,  B81C1/00333 ,  H01L21/561 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/5387 ,  H01L23/5389 ,  H01L24/97 ,  H01L2221/68345 ,  H01L2224/04105 ,  H01L2224/20 ,  H01L2224/211 ,  H01L2224/24137 ,  H01L2224/97 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01057 ,  H01L2924/01061 ,  H01L2924/01074 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12044 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/1461 ,  H01L2924/1815 ,  H01L2924/19043 ,  H01L2224/82 ,  H01L2924/00

Abstract: A method for manufacturing integrated objects, e.g., electronic devices, biological devices. The method includes providing a holder substrate, which has at least one recessed region, the recessed region having a predetermined shape. The holder substrate has a selected thickness and is characterized as being substantially rigid in shape. The method includes aligning a chip comprising a face and a backside into the predetermined shape of the recessed region and disposing the chip into the recessed region. The chip is secured into the recessed region. The method includes providing a first film of insulating material having a first thickness overlying the face and portions of the holder substrate to attach the chip to a portion of the first film of insulating material and patterning the first film of insulating material to form at least one opening through a portion of the first thickness to a contact region on the face of the chip. The method includes forming a metallization layer overlying the first film of insulating material to couple to the contact region through the one opening and forming a protective layer overlying the metallization layer. The method includes releasing the chip from the holder substrate while maintaining attachment of the chip to the first film of insulating material.

Abstract translation: 一种用于制造诸如电子装置的生物装置的集成物体的方法。 该方法包括提供具有至少一个凹陷区域的保持器基底，该凹陷区域具有预定形状。 保持器基板具有选定的厚度，并且其特征在于其形状基本上是刚性的。 该方法包括将包括面和背面的芯片对准到凹陷区域的预定形状，并将芯片设置在凹陷区域中。 芯片固定在凹陷区域内。 该方法包括提供绝缘材料的第一膜，其具有覆盖在保持器基板的表面和部分上的第一厚度，以将芯片附接到第一绝缘材料膜的一部分，并且使第一绝缘材料膜形成图案以形成至少一个 通过第一厚度的一部分打开到芯片的表面上的接触区域。 该方法包括形成覆盖绝缘材料的第一膜的金属化层，以通过一个开口耦合到接触区域并形成覆盖金属化层的保护层。 该方法包括从保持器基板释放芯片，同时保持芯片与第一绝缘材料膜的连接。

公开(公告)号：WO2005045470A3

公开(公告)日：2005-11-03

申请号：PCT/US2004035985

申请日：2004-10-27

Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  LIGER MATTHIEU ,  MISERENDINO SCOTT

Inventor： TAI YU-CHONG ,  LIGER MATTHIEU ,  MISERENDINO SCOTT

IPC: G01J5/00 ,  G01J5/20 ,  G01T20060101 ,  H01L31/101

CPC classification number: G01J5/20 ,  H01L31/101

Abstract: A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

Abstract translation: 一种用于制造感测装置的方法（和结果）。 该方法包括提供包括表面区域并形成覆盖表面区域的绝缘材料的基板。 该方法还包括形成覆盖绝缘材料的碳基材料薄膜，并处理碳基材料薄膜以热解碳基材料，以形成电阻率范围在预定范围内的基本上碳基材料的薄膜。 该方法还在传感器应用中提供热解碳基材料的至少一部分，并且在感测应用中使用部分热解碳基材料。 在具体实施例中，感测应用选自化学，湿度，压电，辐射，机械应变或温度。

公开(公告)号：WO2004065290A3

公开(公告)日：2005-08-18

申请号：PCT/US2004001052

申请日：2004-01-14

Applicant: CALIFORNIA INST OF TECHN ,  XIE JUN ,  SHIH JASON ,  TAI YU-CHONG

Inventor： XIE JUN ,  SHIH JASON ,  TAI YU-CHONG

IPC: B81B3/00 ,  B81C20060101 ,  F04B1/00 ,  F04B17/00 ,  F04B37/02 ,  F04B43/04 ,  F04B43/08 ,  F04B43/12 ,  F04F99/00 ,  H01B13/00

CPC classification number: B81C1/00119 ,  B81B2201/036 ,  B81B2203/0127 ,  B81B2203/0338 ,  F04B43/043 ,  F04B43/082 ,  F04B43/12 ,  Y10T137/87692

Abstract: An electrostatic fluid regulating device and methods. The device has a substrate. The device also has a first electrode coupled to the substrate. The device has a polymer based diaphragm. A second electrode is coupled to the diaphragm. A polymer based fluid chamber is coupled to the diaphragm. The device also has an inlet coupled to the polymer based fluid chamber and an outlet coupled to the polymer based fluid chamber.

Abstract translation: 一种静电流体调节装置及方法。 该装置具有基板。 该器件还具有耦合到衬底的第一电极。 该装置具有基于聚合物的隔膜。 第二电极耦合到隔膜。 基于聚合物的流体室耦合到隔膜。 该装置还具有连接到基于聚合物的流体室的入口和连接到基于聚合物的流体室的出口。

公开(公告)号：WO03081968A8

公开(公告)日：2004-05-13

申请号：PCT/US0308176

申请日：2003-03-18

Applicant: CALIFORNIA INST OF TECHN ,  TAI YU-CHONG ,  HE QING

Inventor： TAI YU-CHONG ,  HE QING

IPC: B01L3/00 ,  B81B3/00 ,  B81B7/00 ,  G01N30/56 ,  G01N30/60 ,  H05K3/02 ,  B05D1/12 ,  B05D1/36 ,  B05D3/12 ,  B44C1/22 ,  C23F1/00 ,  D06L3/12 ,  H05K3/10 ,  C03C1/22

CPC classification number: B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

Abstract: A method for integrally fabricated MEMs devices with include micro or nanoparticles by providing a mixture (16) of sacrificial material (12) and a multiplicity of particles (10), disposing the mixture (16) on a substrate (14), fabricating a MEMs structure on the substrate (14) including at least part of the mixture (16), so that at least some of the mixture (16) is enclosed in the MEMs structure, removing the sacrificial material (12), and leaving at least some of the multiplicity of particles (10) substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles (10), which may be microbeads or nanobeads, are included.

Abstract translation: 一种通过提供牺牲材料（12）的混合物（16）和多个颗粒（10），将混合物（16）设置在基底（14）上的，用于整体制造的MEM装置的方法，其包括微型或纳米颗粒，制造MEM 包括至少部分混合物（16）的衬底（14）上的结构，使得混合物（16）中的至少一些被封闭在MEM结构中，去除牺牲材料（12），并且留下至少一些 基本上游离并包围在MEMs结构中的颗粒（10）的多样性。 制造MEMs结构的步骤是相当普遍的，并且被设想为包括用于产生某些类型的结构的一个或多个附加步骤，其中可以包括可以是微珠或纳米珠的颗粒（10）。