中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

50 records (took 0.019 seconds)

    SYSTEM AND METHOD FOR FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING
    35.
    发明申请
    SYSTEM AND METHOD FOR FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING 审中-公开
    用于光纤阵列光纤转换器的聚合物筛选系统和方法

    公开(公告)号：WO2007103894A3

    公开(公告)日：2008-04-03

    申请号：PCT/US2007063341

    申请日：2007-03-05

    Applicant: CHEMIMAGE CORP ,  TUSCHEL DAVID ,  TREADO PATRICK J ,  NELSON MATTHEW P

    Inventor： TUSCHEL DAVID ,  TREADO PATRICK J ,  NELSON MATTHEW P

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01J3/0221 ,  G01J3/2823 ,  G01N21/474 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/0833

    Abstract: The present disclosure describes methods and systems that combine Raman spectroscopy performed in a manner that utilizes one or more of widefield illumination, simultaneous multipoint Raman spectral acquisition, and spectral unmixing for the purpose of high throughput polymorph screening. Features of this methodology include: (a) high throughput polymorph screening to reduce crystal orientation effects on Raman spectra; (b) in- well multi-polymorph screening using increased statistical sampling; and (c) multipoint spectral sampling to enable spectral unmixing.

    Abstract translation: 本公开描述了组合拉曼光谱的方法和系统，其以利用一种或多种宽场照明，同时多点拉曼光谱采集和光谱解混合的方式进行，以进行高通量多晶型筛选。 该方法的特点包括：（a）高通量多晶型筛选以减少对拉曼光谱的晶体取向效应; （b）使用增加的统计学抽样的多孔多态性筛选; 和（c）多点光谱采样以使光谱解混合。

    CYTOLOGICAL METHODS FOR DETECTING A DISEASE CONDITION SUCH AS MALIGNANCY BY RAMAN SPECTROSCOPIC IMAGING
    36.
    发明申请
    CYTOLOGICAL METHODS FOR DETECTING A DISEASE CONDITION SUCH AS MALIGNANCY BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
    用于通过拉曼光谱成像检测疾病状态如恶性肿瘤的细胞学方法

    公开(公告)号：WO2006135628A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2006022083

    申请日：2006-06-06

    Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  STEWART SHONA ,  TREADO PATRICK J

    Inventor： MAIER JOHN S ,  STEWART SHONA ,  TREADO PATRICK J

    IPC: G01J3/44 ,  A61B6/00

    CPC classification number: G01N21/65 ,  G01N2021/656

    Abstract: Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.

    Abstract translation: 拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。 例如，本公开包括使用RMI来区分正常和患病细胞或组织，例如癌细胞，以及确定所述癌细胞的等级。 在一个优选实施方案中，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾，乳腺和结肠以及非上皮组织，例如骨髓和脑。 可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。 此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

    METHOD AND APPARATUS FOR A MICROSCOPE IMAGE SELECTOR
    37.
    发明申请
    METHOD AND APPARATUS FOR A MICROSCOPE IMAGE SELECTOR 审中-公开
    一种显微镜图像选择器的方法和装置

    公开(公告)号：WO2006083716A3

    公开(公告)日：2007-04-19

    申请号：PCT/US2006002976

    申请日：2006-01-30

    Applicant: CHEMIMAGE CORP ,  WANG XINGHUA ,  VOIGHT THOMAS ,  TUSCHEL DAVID ,  WANG CHENHUI ,  TREADO PATRICK J

    Inventor： WANG XINGHUA ,  VOIGHT THOMAS ,  TUSCHEL DAVID ,  WANG CHENHUI ,  TREADO PATRICK J

    IPC: G01J3/00 ,  G01J3/28 ,  G01J3/40 ,  G01J3/42 ,  G01J3/44 ,  G01N21/25

    CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/36 ,  G01J3/44 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/656

    Abstract: The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample (100). In one embodiment, the apparatus includes an image selector (108) having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector (108) adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret (102) housing a second plurality of components, the microscope turret (102) adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret (102) adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.

    Abstract translation: 本公开内容通常涉及用于同时获得样本（100）的多个波长鉴别光谱图像的多模式成像装置。 在一个实施例中，该装置包括具有旋转器组件的图像选择器（108），旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导至样品 ，所述图像选择器（108）适于接收与所述样本相互作用的照明光子并选择性地将所述相互作用的光子引导到多个检测源中的一个; 显微镜转台（102），其容纳第二多个部件，所述显微镜转台（102）适于接收具有第二波长的照射光子并将所述光子引导到所述样品; 适于接收与样品相互作用的照明光子并且将所述相互作用的光子选择性地引导到多个检测源中的一个的微观炮塔（102）; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

Patent Agency Ranking